发表一篇学和医学成像类SCI论文
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Abstract:
BACKGROUND:Primary antibody deficiencies (PADs) are the most prevalent primary immunodeficiencies. More severe forms of PADs-common variable immunodeficiency (CVID) and X-linked agammaglobulinemia (XLA)-require immunoglobulin replacement therapy (IRT) and may have serious complications. Differentiating severe PAD from milder hypogammaglobulinemia not requiring IRT can involve prolonged evaluations and treatment discontinuation. Severe PAD is defined by plasma cell deficiency, but this requires a biopsy to establish. Serum B-cell maturation antigen (sBCMA) is elevated in multiple myeloma, but levels are reduced among patients with myeloma in remission who have hypogammaglobulinemia. OBJECTIVE:To measure the sBCMA level in 165 subjects to determine whether it differentiates severe PAD-CVID and XLA-from less severe forms not requiring IRT and those without PAD. METHODS:sBCMA, B cells, and tissue plasma cells were measured among subjects with and without PAD, and correlated to clinical and laboratory data. RESULTS:Subjects with an IgG level of less than 600 mg/dL had reduced sBCMA levels compared with subjects with PAD with IgG levels of greater than or equal to 600 mg/dL and controls without PAD. sBCMA level was lower in patients with CVID and XLA compared with patients with IgA or IgG deficiency and controls. sBCMA level correlated with gastrointestinal plasma cells. sBCMA level of less than 15 ng/mL had 97% positive predictive value for CVID or XLA, whereas 25 ng/mL or more had an 88% negative predictive value. CONCLUSIONS:sBCMA level is profoundly reduced in patients with severe PAD, including those with CVID and XLA and those with IgG levels of less than 600 mg/dL. sBCMA level measurement has potential to augment clinical evaluation of PAD. Prospective studies are needed to evaluate sBCMA for new PAD diagnosis and determine the necessity of IRT.
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最新影响因子:11.022 | 期刊ISSN:2213-2198 | CiteScore:2.86 |
出版周期: | 是否OA:YES | 出版年份:0 |
自引率:24.80% | 研究方向:ALLERGYIMMUNOLOGY-IMMUNOLOGY |
出版地区:NETHERLANDS |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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JACI: In Practice covers the spectrum of conditions treated by allergist-immunologists in their practices. The emphasis of the journal is on information that is practical for clinicians-material that can be used in everyday practice or will help in acquiring new knowledge or skills that can be directly applied to patients. A major goal of JACI: In Practice is to provide our readers with a high level of evidence to support their clinical decisions in diagnosis and management.
JACI:在实践中涵盖了变态反应学家在实践中治疗的各种情况。该杂志的重点是为临床医生提供实用的信息,这些信息可以在日常实践中使用,或者有助于获得可以直接应用于患者的新知识或技能。JACI的一个主要目标是:在实践中为我们的读者提供高水平的证据,以支持他们在诊断和管理方面的临床决策。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
ALLERGY (过敏) 2区 IMMUNOLOGY (免疫学) 2区 |
2/27 21/155 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
173 | 122 | 51 |
引文计数(2018)
文献(2015-2017)
1974次引用
691篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Immunology and Allergy
|
#66/170
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研究方向:过敏 哮喘 关节炎
liting7111
研究方向:临床免疫学
审稿时间: 3个月内 接受率: 非常困难(几乎不命中)
影响因子:2.995
ISSN:0028-3940
研究方向:医学-核医学
影响因子:2.324
ISSN:1051-2284
研究方向:医学-核医学
影响因子:3.156
ISSN:1869-1439
研究方向:CLINICAL NEUROLOGY-RADIOLOGY, NUCLEAR MEDICINE & M
影响因子:4.6
ISSN:0150-9861
研究方向:医学-核医学
影响因子:1.764
ISSN:1591-0199
研究方向:CLINICAL NEUROLOGY-RADIOLOGY, NUCLEAR MEDICINE & M
影响因子:4.966
ISSN:0195-6108
研究方向:医学-核医学
影响因子:3.005
ISSN:0301-0449
研究方向:医学-核医学
影响因子:2.396
ISSN:1793-5458
研究方向:OPTICS-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGI
影响因子:3.632
ISSN:1084-9785
研究方向:医学-核医学
发表一篇学和医学成像类SCI论文
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