Hair cortisol levels in posttraumatic stress disorder and metabolic syndrome.切换为中文
:Individuals with post-traumatic stress disorder (PTSD) evidence increased rates of metabolic syndrome (MetS), and both PTSD and MetS are associated with alterations in hypothalamic-pituitary-adrenal (HPA) axis function. Few investigations have examined the possible role of HPA-axis dysfunction in the co-occurrence of PTSD and MetS. In a case-control study, we aimed to determine whether hair cortisol concentrations (HCC) were associated with (i) PTSD caseness and severity and (ii) PTSD and MetS co-occurrence. We used the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) to determine PTSD diagnoses and severity scores in 216 females of mixed ancestry aged between 20 and 79 years (M = 43.8, SD =13.3). Hair samples, representing a three-month retrospective window of cortisol levels, were obtained and analyzed utilizing liquid chromatography-tandem mass spectrometry. We constructed multivariate linear regression models to evaluate whether PTSD diagnosis, PTSD severity, and MetS comorbidity were associated with HCC, controlling for potential confounders. HCC were significantly higher (adj β = 0.154, p = .033; Cohen's d = 0.44) in PTSD patients (n = 110) than trauma-exposed controls (n = 106) and CAPS severity scores (adj β = 0.207, p = .005) were significantly associated with HCC. MetS was not associated with HCC and there were no significant interactions between PTSD and MetS on HCC. This study provides evidence of a chronically dysregulated neuroendocrine mediated stress response in PTSD, with a clear dose-response relationship. HCC do not, however, appear to have specificity for the comorbidity of PTSD and MetS in this sample.LAY SUMMARYWe found that levels of the stress hormone, cortisol, measured in hair samples were significantly higher in South African women with post-traumatic stress disorder (PTSD) than in women who had also experienced trauma but did not have PTSD. Hair cortisol levels were, however, not associated with metabolic syndrome, a cluster of risk factors for heart disease, in the women studied. We thus show that South African women with PTSD have elevated long-term stress hormone levels and that this effect is related to PTSD and not solely due to trauma exposure.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS 期刊简介
The journal Stress aims to provide scientists involved in basic stress research with the possibility of reading a more integrated view of the field. Peer reviewed papers, invited reviews and short communications will deal with interdisciplinary aspects of stress in terms of: the mechanisms of stressful stimulation, including within and between individuals; the physiological and behavioural responses to stress, and their regulation, in both the short and long term; adaptive mechanisms, coping strategies and the pathological consequences of stress. Stress will publish the latest developments in physiology, neurobiology, molecular biology, genetics research, immunology, and behavioural studies as they impact on the understanding of stress and its adverse consequences and their amelioration. Specific approaches may include transgenic animals, developmental/programming studies, electrophysiology, histochemistry, neurochemistry, neuropharmacology, neuroanatomy, endocrinology, autonomic physiology, immunology, chronic pain, ethological and other behavioural studies and clinical measures.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS 期刊中科院评价数据
BEHAVIORAL SCIENCES(行为科学) 3区
ENDOCRINOLOGY & METABOLISM(内分泌学和新陈代谢) 3区
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS 期刊CiteScore评价数据
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS 期刊常见问题
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS 投稿经验
研究方向：BIOCHEMISTRY & MOLECULAR BIOLOGY-CHEMISTRY, MEDICI