
发表一篇学和医学成像类SCI论文
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Abstract:
:The known effects of aging on the brain and behavior include impaired cognition, increases in anxiety and depressive-like behaviors, and reduced locomotor activity. Environmental exposures and interventions also influence brain functions during aging. We investigated the effects of normal aging under controlled environmental conditions and in the absence of external interventions on locomotor activity, cognition, anxiety and depressive-like behaviors, immune function and hippocampal gene expression in C57BL/6 mice. Healthy mice at 4, 9, and 14 months of age underwent behavioral testing using an established behavioral battery, followed by cellular and molecular analysis using flow cytometry, immunohistochemistry, and quantitative PCR. We found that 14-month-old mice showed significantly reduced baseline locomotion, increased anxiety, and impaired spatial memory compared to younger counterparts. However, no significant differences were observed for depressive-like behavior in the forced-swim test. Microglia numbers in the dentate gyrus, as well as CD8+ memory T cells increased towards late middle age. Aging processes exerted a significant effect on the expression of 43 genes of interest in the hippocampus. We conclude that aging is associated with specific changes in locomotor activity, cognition, anxiety-like behaviors, neuroimmune responses and hippocampal gene expression.
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最新影响因子:3.352 | 期刊ISSN:0166-4328 | CiteScore:3.11 |
出版周期:Semimonthly | 是否OA:YES | 出版年份:1980 |
期刊官方网址:http://www.journals.elsevier.com/behavioural-brain-research/
期刊投稿地址:http://www.journals.elsevier.com/behavioural-brain-research/
自引率:5.40% | 研究方向:医学-行为科学 |
出版地区:NETHERLANDS |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.
《行为大脑研究》是一本国际性、跨学科的期刊,专门发表广义上的行为神经科学领域的文章。只要目标是描述行为背后的神经机制,来自包括神经科学、行为科学或认知科学在内的整个学科领域的贡献都是合适的。因此,研究范围可能从神经生理学、神经解剖学、神经化学或神经药理学分析脑行为关系,包括使用分子遗传学或行为遗传学方法,到涉及使用脑成像技术的研究,到神经行为学研究。报告的原始研究,主要方法的进步,或新的概念方法都是鼓励。该杂志还将考虑对选定主题的评论。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
BEHAVIORAL SCIENCES (行为科学) 3区 NEUROSCIENCES (神经科学) 3区 |
14/51 119/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
619 | 598 | 21 |
引文计数(2018)
文献(2015-2017)
5712次引用
1838篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Neuroscience
小类(学科):Behavioral Neuroscience
|
#11/68
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审稿时间: 2个月内 接受率: 一般容易(75%命中)
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研究方向:神经科学 认知科学 脑疾病
审稿时间: 2个月内 接受率: 中等(50%命中)
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研究方向:神经行为学 神经化学 代谢组学
接受率: 一般容易(75%命中)
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研究方向:神经医学 行为学 认知
接受率: 中等(50%命中)
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研究方向:神经科学 行为学 脑部疾病
审稿时间: 2个月内 接受率: 中等(50%命中)
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研究方向:生命科学 神经科学 认知科学 心理学
审稿时间: 1个月内
影响因子:2.473
ISSN:1362-4393
研究方向:医学-临床神经学
影响因子:1.14
ISSN:1443-9646
研究方向:CLINICAL NEUROLOGY-NEUROSCIENCES
影响因子:1.986
ISSN:1053-8135
研究方向:CLINICAL NEUROLOGY-REHABILITATION
影响因子:1.907
ISSN:1751-8423
研究方向:CLINICAL NEUROLOGY-PEDIATRICS
影响因子:3.117
ISSN:0885-9701
研究方向:医学-康复医学
影响因子:4.895
ISSN:1545-9683
研究方向:医学-康复医学
影响因子:4.655
ISSN:1557-0576
研究方向:CLINICAL NEUROLOGY-REHABILITATION
影响因子:1.452
ISSN:0898-5669
研究方向:PEDIATRICS-REHABILITATION
影响因子:2.297
ISSN:0194-2638
研究方向:PEDIATRICS-REHABILITATION
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