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Abstract:
OBJECTIVES:To explore the characteristics of IDH and TERT promoter mutations in gliomas in Chinese patients. METHODS:A total of 124 Chinese patients with gliomas were enrolled to study the frequencies of mutations in isocitrate dehydrogenase (IDH) and telomerase reverse transcriptase promoter (TERTp). Among the 124 patients, 59 patients were enrolled to study the classification of gliomas based on mutations in IDH and TERTp. RESULTS:Isocitrate dehydrogenase mutations are positively correlated with a good prognosis but mutations in TERTp cannot predict prognoses independently. The combined analysis of the mutations of IDH and TERTp can predict the prognosis more accurately. Patients with IDH and TERTp glioma mutations have the best prognosis, followed by only IDH mutation patients and only TERTp mutation patients, which have the worst prognosis. IDH and TERTp mutations occur frequently in males, younger patients or lower-grade patients. In contrast, only TERTp mutations occur frequently in females, older patients or higher-grade patients. CONCLUSIONS:Patients with IDH and TERTp glioma mutations have the best prognosis, and only IDH mutation patients and only TERTp mutation patients have the worst prognosis. Moreover, the molecular classification of gliomas by mutations of IDH and TERTp is not suitable for pediatric patients.
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最新影响因子:3.405 | 期刊ISSN:2162-3279 | CiteScore:2.39 |
出版周期: | 是否OA:YES | 出版年份:0 |
期刊官方网址:http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2157-9032
自引率:1.00% | 研究方向:BEHAVIORAL SCIENCES-NEUROSCIENCES |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Brain and Behavior is peer-reviewed, open access, interdisciplinary journal, providing rapid publication of scientifically sound research across neurology, neuroscience, psychology and psychiatry. The journal publishes quality research reports that enhance understanding of the brain and behavior. The e journal strives to help authors and look for reasons to publish rather than reject. The journal's broad scope considers empirical and theoretical submissions in areas including, but not limited to mechanisms and treatment of psychiatric disorders and neurological diseases behavioral and cognitive science clinical, social, developmental, and cognitive psychology neurosurgery, neuroimaging, and neuroimmunology epidemiology and genetics of psychological and neurological conditions emerging technologies and new research methods
《大脑与行为》是一本跨学科期刊,由同行评审、开放获取,提供跨神经学、神经科学、心理学和精神病学的科学合理研究的快速出版。该杂志发表了提高对大脑和行为理解的高质量研究报告。电子期刊致力于帮助作者,寻找出版而非拒绝的理由。该期刊的广泛范围考虑了包括但不限于: 精神疾病和神经疾病的机制和治疗 行为和认知科学 临床、社会、发展和认知心理学 神经外科、神经影像学和神经免疫学 心理和神经疾病的流行病学和遗传学 新兴技术与新研究方法
大类(学科) | 小类(学科) | 学科排名 |
医学 |
BEHAVIORAL SCIENCES (行为科学) 4区 NEUROSCIENCES (神经科学) 4区 |
30/51 184/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
267 | 261 | 6 |
引文计数(2018)
文献(2015-2017)
855次引用
357篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Neuroscience
小类(学科):Behavioral Neuroscience
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#34/68
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研究方向:neurology
审稿时间: 6个月内 接受率: 一般容易(75%命中)
影响因子:2.995
ISSN:0028-3940
研究方向:医学-核医学
影响因子:2.324
ISSN:1051-2284
研究方向:医学-核医学
影响因子:3.156
ISSN:1869-1439
研究方向:CLINICAL NEUROLOGY-RADIOLOGY, NUCLEAR MEDICINE & M
影响因子:4.6
ISSN:0150-9861
研究方向:医学-核医学
影响因子:1.764
ISSN:1591-0199
研究方向:CLINICAL NEUROLOGY-RADIOLOGY, NUCLEAR MEDICINE & M
影响因子:4.966
ISSN:0195-6108
研究方向:医学-核医学
影响因子:3.005
ISSN:0301-0449
研究方向:医学-核医学
影响因子:2.396
ISSN:1793-5458
研究方向:OPTICS-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGI
影响因子:3.632
ISSN:1084-9785
研究方向:医学-核医学
发表一篇学和医学成像类SCI论文
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