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Prednisolone Prophase for a Week Versus Upfront Multiagent Chemotherapy in Childhood Acute Lymphoblastic Leukemia: An Analysis With Reference to Induction Mortality in a Developing Country.

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Abstract:

:In childhood acute lymphoblastic leukemia, high treatment-related mortality, especially in the induction phase of treatment, is a major challenge for developing countries. The reasons are multifactorial, including a late presentation with higher disease burden, malnourishment, and limited support services. These factors may aggravate the toxic effects of upfront multiagent chemotherapy in terms of severe neutropenic sepsis and tumor lysis. Therefore, instead of upfront chemotherapy, we offered prednisolone prophase for 1 week with the objective of balancing the antileukemic versus the toxic effect of treatment. The data of 538 patients who received induction with this approach (cohort B) are compared for induction mortality with previous records of 438 patients (cohort A) treated with upfront chemotherapy. In the presence of similar clinical characteristics including age, sex, risk group, and phenotype in both cohorts, a significant difference was found in overall induction mortality of 9% in cohort B versus 14% in cohort A (P<0.05). This difference was also significant in the high-risk and T-cell phenotype, which strengthens our hypothesis that patients with higher burden of disease may experience more fatal toxic effects with upfront intensive chemotherapy. Therefore, we suggest that the prednisolone prophase approach is beneficial to control the disease with less severe toxic effects in our settings.

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JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

J PEDIAT HEMATOL ONC
最新影响因子:1.016 期刊ISSN:1077-4114 CiteScore:
出版周期:Bimonthly 是否OA:YES 出版年份:1995

期刊官方网址:http://journals.lww.com/jpho-online/pages/default.aspx

期刊投稿地址:http://www.editorialmanager.com/jpho/default.aspx

自引率:5.00% 研究方向:医学-小儿科
出版地区:UNITED STATES

SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)

NCBI查询:PubMed Central (PMC)链接全文检索(pubmed central)

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JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY 期刊简介

英文简介:

Published by Lippincott Williams and Wilkins. ISSN: 1077-4114. The Journal of Pediatric Hematology / Oncology reports on major advances in the diagnosis and treatment of cancer and blood diseases in children. Each bimonthly issue presents informative case studies and original research articles from leading clinicians and investigators worldwide. Also featured are specially developed Continuing Seminars, which serve the continuing education needs of physicians by offering new insights into many areas of interest, as well as analyses of radiological problems in pediatric hematology / oncology and discussions of pertinent ethical and legal issues.

中文简介:(来自Google、百度翻译)

由Lippincott Williams和Wilkins出版。ISSN: 1077 - 4114。 《儿科血液学/肿瘤学杂志》报告了在儿童癌症和血液疾病的诊断和治疗方面的重大进展。每一期双月刊提供来自世界领先临床医生和研究人员的有价值的案例研究和原创研究文章。专题还包括专门开发的持续研讨会,通过对许多感兴趣的领域提供新的见解,分析儿科血液学/肿瘤学中的放射学问题,讨论相关的伦理和法律问题,从而满足医生的继续教育需求。

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JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY 期刊中科院评价数据

最新中科院分区

大类(学科) 小类(学科) 学科排名
医学 HEMATOLOGY(血液学) 4区
ONCOLOGY(肿瘤学) 4区
PEDIATRICS(儿科学) 4区
65/71
213/223
98/124

最新公布的期刊年发文量

年度总发文量 年度论文发表量 年度综述发表量
242 224 18
总被引频次:3658
特征因子:0.005040

影响因子趋势图

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JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY 期刊CiteScore评价数据

最新CiteScore值

=

引文计数(2018)

文献(2015-2017)

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次引用

篇文献

文献总数(2014-2016):
被引比率:%
SJR:
SCLmago期刊等级衡量经过加权后的期刊受引用次数,引用次数的加权值由施引期刊的学科领域和声望(SJR)决定。
SNIP:
每篇文章中来源出版物的标准化影响将实际受引用情况对照期刊所属学科领域中预期的受引用情况进行衡量。

CiteScore排名

序号 类别 排名 百分位

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JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY 投稿经验

(由下方点评分析获得,2人参与,1523人阅读)

  • 偏重的研究方向:
  • 投稿录用比例:
    暂无
  • 审稿速度:
    平均3个月的审稿周期(非官方数据)

最新评论(不代表本站观点)

  • avatar

    liting7111

    接受率: 比较困难(25%命中)

    投稿后,一审意见主要是觉得细胞株只有一个太少了,花了三个月时间按照要求多做了一个,审稿两个月结果拒稿了!理由是接收率只有25%,你倒是在一审的时候就给我拒稿了啊!
    2020-01-18
  • avatar

    liting7111

    研究方向:儿童血液

    审稿时间: 3个月内 接受率: 比较困难(25%命中)

    审稿比较慢,一审等了三个月才给意见,大修,投回去几周才通知拒稿。问过其他投过这本的,都说审稿周期长!
    2019-05-23

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