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Abstract:
:In childhood acute lymphoblastic leukemia, high treatment-related mortality, especially in the induction phase of treatment, is a major challenge for developing countries. The reasons are multifactorial, including a late presentation with higher disease burden, malnourishment, and limited support services. These factors may aggravate the toxic effects of upfront multiagent chemotherapy in terms of severe neutropenic sepsis and tumor lysis. Therefore, instead of upfront chemotherapy, we offered prednisolone prophase for 1 week with the objective of balancing the antileukemic versus the toxic effect of treatment. The data of 538 patients who received induction with this approach (cohort B) are compared for induction mortality with previous records of 438 patients (cohort A) treated with upfront chemotherapy. In the presence of similar clinical characteristics including age, sex, risk group, and phenotype in both cohorts, a significant difference was found in overall induction mortality of 9% in cohort B versus 14% in cohort A (P<0.05). This difference was also significant in the high-risk and T-cell phenotype, which strengthens our hypothesis that patients with higher burden of disease may experience more fatal toxic effects with upfront intensive chemotherapy. Therefore, we suggest that the prednisolone prophase approach is beneficial to control the disease with less severe toxic effects in our settings.
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最新影响因子:1.17 | 期刊ISSN:1077-4114 | CiteScore: |
出版周期:Bimonthly | 是否OA:YES | 出版年份:1995 |
期刊官方网址:http://journals.lww.com/jpho-online/pages/default.aspx
自引率:5.00% | 研究方向:医学-小儿科 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Published by Lippincott Williams and Wilkins. ISSN: 1077-4114. The Journal of Pediatric Hematology / Oncology reports on major advances in the diagnosis and treatment of cancer and blood diseases in children. Each bimonthly issue presents informative case studies and original research articles from leading clinicians and investigators worldwide. Also featured are specially developed Continuing Seminars, which serve the continuing education needs of physicians by offering new insights into many areas of interest, as well as analyses of radiological problems in pediatric hematology / oncology and discussions of pertinent ethical and legal issues.
由Lippincott Williams和Wilkins出版。ISSN: 1077 - 4114。 《儿科血液学/肿瘤学杂志》报告了在儿童癌症和血液疾病的诊断和治疗方面的重大进展。每一期双月刊提供来自世界领先临床医生和研究人员的有价值的案例研究和原创研究文章。专题还包括专门开发的持续研讨会,通过对许多感兴趣的领域提供新的见解,分析儿科血液学/肿瘤学中的放射学问题,讨论相关的伦理和法律问题,从而满足医生的继续教育需求。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
HEMATOLOGY (血液学) 4区 ONCOLOGY (肿瘤学) 4区 PEDIATRICS (儿科) 4区 |
65/71 213/223 98/124 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
242 | 224 | 18 |
引文计数(2018)
文献(2015-2017)
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研究方向:儿童血液
审稿时间: 3个月内 接受率: 比较困难(25%命中)
影响因子:0.549
ISSN:0025-6544
研究方向:医学-力学
影响因子:1.59
ISSN:0309-1929
研究方向:地学天文-地球化学与地球物理
影响因子:0
ISSN:1541-0161
研究方向:物理-工程:机械
影响因子:4.761
ISSN:0022-460X
研究方向:工程技术-工程:机械
影响因子:2.633
ISSN:1077-5463
研究方向:工程技术-工程:机械
影响因子:2.04
ISSN:1475-472X
研究方向:ACOUSTICS-ENGINEERING, AEROSPACE
影响因子:0.632
ISSN:1027-5851
研究方向:ACOUSTICS-ENGINEERING, MECHANICAL
影响因子:1.701
ISSN:1048-9002
研究方向:工程技术-工程:机械
影响因子:2.446
ISSN:0021-8464
研究方向:工程技术-材料科学:综合
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