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Abstract:
:The aim of this trial was to decrease the incidence of life-threatening infections by decreasing the dose and the duration of dexamethasone treatment during maintenance therapy. This was a prospective, nonrandomized trial of low-risk acute lymphoblastic leukemia patients aged 1 to 18 years who were treated at the Children's Cancer Center of Lebanon (CCCL). Patients consecutively diagnosed between 2002 and 2013 were divided into groups 1 and 2 receiving total dexamethasone doses of 1144 and 618 mg/m, respectively. A total of 84 patients were assigned to group 1 and 33 patients to group 2. The 5-year cumulative incidence of isolated central nervous system relapse increased from (n=0% [95% confidence interval: 0%-4.4%]) in group 1 to 9.1% [95% confidence interval: 3%-23%]; P=0.021) in group 2. Decreasing cumulative dose of dexamethasone for low-risk childhood acute lymphoblastic leukemia patients aiming to avoid serious viral infections led to a significant increase in isolated central nervous system relapse.
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最新影响因子:1.17 | 期刊ISSN:1077-4114 | CiteScore: |
出版周期:Bimonthly | 是否OA:YES | 出版年份:1995 |
期刊官方网址:http://journals.lww.com/jpho-online/pages/default.aspx
自引率:5.00% | 研究方向:医学-小儿科 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Published by Lippincott Williams and Wilkins. ISSN: 1077-4114. The Journal of Pediatric Hematology / Oncology reports on major advances in the diagnosis and treatment of cancer and blood diseases in children. Each bimonthly issue presents informative case studies and original research articles from leading clinicians and investigators worldwide. Also featured are specially developed Continuing Seminars, which serve the continuing education needs of physicians by offering new insights into many areas of interest, as well as analyses of radiological problems in pediatric hematology / oncology and discussions of pertinent ethical and legal issues.
由Lippincott Williams和Wilkins出版。ISSN: 1077 - 4114。 《儿科血液学/肿瘤学杂志》报告了在儿童癌症和血液疾病的诊断和治疗方面的重大进展。每一期双月刊提供来自世界领先临床医生和研究人员的有价值的案例研究和原创研究文章。专题还包括专门开发的持续研讨会,通过对许多感兴趣的领域提供新的见解,分析儿科血液学/肿瘤学中的放射学问题,讨论相关的伦理和法律问题,从而满足医生的继续教育需求。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
HEMATOLOGY (血液学) 4区 ONCOLOGY (肿瘤学) 4区 PEDIATRICS (儿科) 4区 |
65/71 213/223 98/124 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
242 | 224 | 18 |
引文计数(2018)
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研究方向:儿童血液
审稿时间: 3个月内 接受率: 比较困难(25%命中)
影响因子:13.029
ISSN:1522-8517
研究方向:医学-临床神经学
影响因子:4.506
ISSN:0167-594X
研究方向:医学-临床神经学
影响因子:7.723
ISSN:2162-402X
研究方向:ONCOLOGYIMMUNOLOGY-IMMUNOLOGY
影响因子:4.912
ISSN:1524-9557
研究方向:医学-免疫学
影响因子:12.02
ISSN:2326-6066
研究方向:ONCOLOGY-IMMUNOLOGY
影响因子:3.698
ISSN:1750-9378
研究方向:ONCOLOGY-IMMUNOLOGY
影响因子:6.63
ISSN:0340-7004
研究方向:医学-免疫学
影响因子:3.077
ISSN:1534-7354
研究方向:医学-全科医学与补充医学
影响因子:0
ISSN:1868-8497
研究方向:ONCOLOGY-ENDOCRINOLOGY & METABOLISM
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