Mixed phenotype acute leukemia (MPAL): biological profile, clinical characteristic and treatment outcomes: report of the population-based study.
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Abstract:
OBJECTIVES:The aim of this population-based, retrospective study was to analyze biological and clinical features and treatment results in children diagnosed with MPAL in all Polish pediatric oncology centers between 2007 and 2018. METHODS:Among 2,893 children and adolescents diagnosed and treated for acute leukemia, 39 (1.35%) patients fulfilled the WHO criteria of MPAL. The T/myeloid phenotype was most prevalent. RESULTS:Cytogenetics findings were seen in 2 (5.1%), while chromosomal abnormalities were found in 14 (35.9%) patients. Thirty-two patients achieved CR-1, including 23 (92.0%) treated with ALL-directed chemotherapy and 9 (64.3%) treated with AML-type induction regimens. Within these patients, 4 (12.5%) died due to treatment-related complications and 11 (34.4%) relapsed. Nineteen (63.3%) patients underwent allo-HSCT in CR-1 and 14 (73.7%) of them have been in CR-1. In total, 17 (43.6%) patients remain in CR-1 for 1 - 12 years, including 14 (58.3%) with T/myeloid MPAL. The 5-year pOS and pEFS were 51.8% and 44.2%, respectively. The overall survival for ALL-directed therapy was significantly better than the one for AML-type chemotherapy (p=0.001). It was also better for patients who underwent HSCT in CR-1 (p=0.001). CONCLUSIONS:The prognosis of MPAL is unsatisfactory, but initial treatment with ALL-directed chemotherapy consolidated with allo-HSCT improves the outcomes in MPAL.
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EUROPEAN JOURNAL OF HAEMATOLOGY
EUR J HAEMATOL
| 最新影响因子：2.22 | 期刊ISSN：0902-4441 | CiteScore：2.19 |
| 出版周期：Monthly | 是否OA：YES | 出版年份：1987 |
期刊官方网址：http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0609
| 自引率：4.20% | 研究方向：医学-血液学 |
| 出版地区：DENMARK |
SCI期刊coverage：Science Citation Index Expanded（科学引文索引扩展）
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EUROPEAN JOURNAL OF HAEMATOLOGY 期刊简介
英文简介：
European Journal of Haematology is an international journal for communication of basic and clinical research in haematology. The journal welcomes manuscripts on molecular cellular and clinical research on diseases of the blood vascular and lymphatic tissue and on basic molecular and cellular research related to normal development and function of the blood vascular and lymphatic tissue. The journal furthermore welcomes reviews on clinical haematology and basic research case reports and clinical pictures.
中文简介：（来自Google、百度翻译）
《欧洲血液学杂志》是一本关于血液学基础和临床研究交流的国际性杂志。欢迎有关血管和淋巴组织疾病的分子细胞和临床研究手稿，以及有关血管和淋巴组织正常发育和功能的基本分子和细胞研究手稿。此外，该杂志还欢迎对临床血液学和基础研究病例报告和临床图片的评论。
EUROPEAN JOURNAL OF HAEMATOLOGY 期刊中科院评价数据
最新中科院分区
| 大类(学科) | 小类(学科) | 学科排名 |
| 医学 |
HEMATOLOGY(血液学) 3区 |
36/71 |
最新公布的期刊年发文量
| 年度总发文量 | 年度论文发表量 | 年度综述发表量 |
| 158 | 143 | 15 |
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EUROPEAN JOURNAL OF HAEMATOLOGY 期刊CiteScore评价数据
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引文计数(2018)
文献(2015-2017)
1181次引用
539篇文献
CiteScore排名
| 序号 | 类别 | 排名 | 百分位 |
| 1 |
大类(学科)：Medicine
小类(学科)：Hematology
|
#42/120
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