发表一篇学和医学成像类SCI论文
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Abstract:
:Graft-versus-host disease (GVHD) represents a significant cause of mortality after allogeneic hematopoietic stem cell transplantation (HSCT). NF-kB system is a master regulator of innate immunity responses. It controls the expression of various cytokines and chemokines many of which are involved in GVHD pathogenesis. Chemo(radio) therapy administered during conditioning induces DNA damage and activates DNA damage response (DDR) signaling resulting in irreversible cell cycle arrest - cellular senescence which has been described to be associated with robust pro-inflammatory secretion mostly controlled by NF-kB. The NFKB1 gene encodes the DNA-binding subunit of the NF-kB complex. Using the candidate gene approach, we analyzed possible association of two single-nucleotide polymorphisms (SNPs) rs3774937 C/T and rs3774959 A/G of the NFKB1 gene with GVHD and transplant-related mortality (TRM) occurrence in 109 recipients allografted from HLA-identical donor. Both SNPs in recipients were found to be strongly associated with acute GVHD. Nevertheless, no significant association with chronic GVHD and TRM was found. Presented pilot results contribute to pre-clinical observations and suggest that NF-kB may be an important regulator of HSCT-related inflammatory reactions such as acute GVHD. Novel pathogenic mechanisms of GVHD may arise from perspectives of DDR and cellular senescence where NF-kB plays an essential role.
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最新影响因子:4.03 | 期刊ISSN:0939-5555 | CiteScore:1.82 |
出版周期:Monthly | 是否OA:YES | 出版年份:1991 |
自引率:5.00% | 研究方向:医学-血液学 |
出版地区:GERMANY |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Annals of Hematology covers the whole spectrum of clinical and experimental hematology, hemostaseology, blood transfusion, and related aspects of medical oncology, including diagnosis and treatment of leukemias, lymphatic neoplasias and solid tumors, and transplantation of hematopoietic stem cells. Coverage includes general aspects of oncology, molecular biology and immunology as pertinent to problems of human blood disease. The journal is associated with the German Society for Hematology and Medical Oncology, and the Austrian Society for Hematology and Oncology. The Editor-in-Chief is Arnold Ganser, Department of Hematology, Hemostasis and Oncology, Medizinische Hochschule Hannover.
《血液学年鉴》涵盖了临床和实验血液学、止血学、输血以及肿瘤医学的相关领域,包括白血病、淋巴肿瘤和实体肿瘤的诊断和治疗,以及造血干细胞的移植。内容包括与人类血液病相关的肿瘤学、分子生物学和免疫学的一般方面。该杂志与德国血液学和医学肿瘤学协会,以及奥地利血液学和肿瘤学协会有联系。 主编:阿诺德·甘瑟,德国汉诺威大学血液、止血和肿瘤学系。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
HEMATOLOGY (血液学) 3区 |
28/71 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
201 | 180 | 21 |
引文计数(2018)
文献(2015-2017)
1861次引用
1023篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Hematology
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#51/120
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研究方向:NHL
接受率: 中等(50%命中)
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研究方向:医学 血液学
审稿时间: 3个月内
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研究方向:hematology
审稿时间: 3个月内 接受率: 非常困难(几乎不命中)
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研究方向:移植排斥
审稿时间: 2个月内 接受率: 中等(50%命中)
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接受率: 中等(50%命中)
影响因子:2.995
ISSN:0028-3940
研究方向:医学-核医学
影响因子:2.324
ISSN:1051-2284
研究方向:医学-核医学
影响因子:3.156
ISSN:1869-1439
研究方向:CLINICAL NEUROLOGY-RADIOLOGY, NUCLEAR MEDICINE & M
影响因子:4.6
ISSN:0150-9861
研究方向:医学-核医学
影响因子:1.764
ISSN:1591-0199
研究方向:CLINICAL NEUROLOGY-RADIOLOGY, NUCLEAR MEDICINE & M
影响因子:4.966
ISSN:0195-6108
研究方向:医学-核医学
影响因子:3.005
ISSN:0301-0449
研究方向:医学-核医学
影响因子:2.396
ISSN:1793-5458
研究方向:OPTICS-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGI
影响因子:3.632
ISSN:1084-9785
研究方向:医学-核医学
发表一篇学和医学成像类SCI论文
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