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Aging alters spontaneous and neurotransmitter-mediated Ca2+ signaling in smooth muscle cells of mouse mesenteric arteries.
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Abstract:
OBJECTIVE:Aging impairs MA dilation by reducing the ability of sensory nerves to counteract sympathetic vasoconstriction. This study tested whether altered SMC Ca2+ signals to sympathetic (NE) and sensory (CGRP) neurotransmitters underlie aging-related deficits in vasodilation. METHODS:MAs from young and old mice were pressurized and loaded with Fluo-4 dye for confocal measurement of SMC Ca2+ sparks and waves. Endothelial denudation resolved the influence of ECs. SMCs were immunolabeled for RyR isoforms and compared to transcript levels for RyRs and CGRP receptor components. RESULTS:SMCs from young vs. old mice exhibited more spontaneous Ca2+ spark sites with no difference in Ca2+ waves. NE reduced spark sites and increased waves for both groups; addition of CGRP restored sparks and reduced waves only for young mice. Endothelial denudation attenuated Ca2+ responses to CGRP for young but not old mice, which were already attenuated, suggesting a diminished role for ECs with aging. CGRP receptor expression was similar between ages with increased serum CGRP in old mice, where RyR1 expression was replaced by RyR3. CONCLUSION:With aging, we suggest that altered RyR expression in SMCs contributes to impaired ability of sensory neurotransmission to restore Ca2+ signaling underlying vasomotor control during sympathetic activation.
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MICROCIRCULATION
MICROCIRCULATION
| 最新影响因子：2.679 | 期刊ISSN：1073-9688 | CiteScore：2.83 |
| 出版周期：Bimonthly | 是否OA：YES | 出版年份：1994 |
期刊官方网址：http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1549-8719
| 自引率：5.50% | 研究方向：医学-外周血管病 |
| 出版地区：UNITED STATES |
SCI期刊coverage：Science Citation Index Expanded（科学引文索引扩展）
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MICROCIRCULATION 期刊简介
英文简介：
Articles published in Microcirculation are a result of investigations contributing significant new information relating to microcirculation addressed at the intact animal, organ, cellular or molecular level. The journal publishes articles that describe applications of methods in physiology, vascular surgery, cell biology, bioengineering, pathology, genetics, biophysics, molecular biology, biochemistry and immunology. Microcirculation also publishes state-of-the-art reviews that address frontier areas or new advances in technology in the field of microcirculatory disease.
中文简介：（来自Google、百度翻译）
Articles published in Microcirculation are a result of investigations contributing significant new information relating to microcirculation addressed at the intact animal, organ, cellular or molecular level. The journal publishes articles that describe applications of methods in physiology, vascular surgery, cell biology, bioengineering, pathology, genetics, biophysics, molecular biology, biochemistry and immunology. Microcirculation also publishes state-of-the-art reviews that address frontier areas or new advances in technology in the field of microcirculatory disease.
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MICROCIRCULATION 期刊中科院评价数据
最新中科院分区
| 大类(学科) | 小类(学科) | 学科排名 |
| 医学 |
HEMATOLOGY (血液学) 3区 PERIPHERAL VASCULAR DISEASE (外周血管病) 3区 |
30/71 29/65 |
最新公布的期刊年发文量
| 年度总发文量 | 年度论文发表量 | 年度综述发表量 |
| 73 | 50 | 23 |
总被引频次：2553
特征因子：0.003530
影响因子趋势图
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MICROCIRCULATION 期刊CiteScore评价数据
最新CiteScore值
2.83
=
引文计数(2018)
文献(2015-2017)
=
547次引用
193篇文献
文献总数（2014-2016）：193
被引比率：80%
SJR：1.14
SCLmago期刊等级衡量经过加权后的期刊受引用次数，引用次数的加权值由施引期刊的学科领域和声望(SJR)决定。
SNIP：0.953
每篇文章中来源出版物的标准化影响将实际受引用情况对照期刊所属学科领域中预期的受引用情况进行衡量。
CiteScore排名
| 序号 | 类别 | 排名 | 百分位 |
| 1 |
大类(学科)：Biochemistry, Genetics and Molecular Biology
小类(学科)：Physiology
|
#60/169
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|
|
| 2 |
大类(学科)：Biochemistry, Genetics and Molecular Biology
小类(学科)：Molecular Biology
|
#159/366
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|
|
| 3 |
大类(学科)：Medicine
小类(学科)：Cardiology and Cardiovascular Medicine
|
#56/327
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|
|
| 4 |
大类(学科)：Medicine
小类(学科)：Physiology (medical)
|
#28/97
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|
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CiteScore趋势图
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