发表一篇学和医学成像类SCI论文
需要多少钱?
Abstract:
:The levels of cell free circulating tumor DNA (ctDNA) in plasma correlated with treatment response and outcome in systemic lymphomas. Notably, in brain tumors, the levels of ctDNA in the cerebrospinal fluid (CSF) are higher than in plasma. Nevertheless, their role in central nervous system (CNS) lymphomas remains elusive. We evaluated the CSF and plasma from 19 patients: 6 restricted CNS lymphomas, 1 systemic and CNS lymphoma, and 12 systemic lymphomas. We performed whole exome sequencing or targeted sequencing to identify somatic mutations of the primary tumor, then variant-specific droplet digital PCR was designed for each mutation. At time of enrolment, we found ctDNA in the CSF of all patients with restricted CNS lymphoma but not in patients with systemic lymphoma without CNS involvement. Conversely, plasma ctDNA was detected in only 2/6 patients with restricted CNS lymphoma with lower variant allele frequencies than CSF ctDNA. Moreover, we detected CSF ctDNA in 1 patient with CNS lymphoma in complete remission and in 1 patient with systemic lymphoma, 3 and 8 months before CNS relapse was confirmed; indicating CSF ctDNA might detect CNS relapse earlier than conventional methods. Finally, in 2 cases with CNS lymphoma, CSF ctDNA was still detected after treatment even though a complete decrease in CSF tumor cells was observed by flow cytometry (FC), indicating CSF ctDNA better detected residual disease than FC. In conclusion, CSF ctDNA can better detect CNS lesions than plasma ctDNA and FC. In addition, CSF ctDNA predicted CNS relapse in CNS and systemic lymphomas.
展开更多
最新影响因子:11.047 | 期刊ISSN:0390-6078 | CiteScore:4.28 |
出版周期: | 是否OA:YES | 出版年份:0 |
期刊官方网址:http://haematologica.org/
自引率:4.00% | 研究方向:HEMATOLOGY- |
出版地区:ITALY |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
专业编辑在线一对一答疑及时解决您的问题
Published by Ferrata Storti Foundation. ISSN: 0390-6078.
由Ferrata Storti基金会出版。ISSN: 0390 - 6078。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
HEMATOLOGY (血液学) 2区 |
5/71 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
239 | 225 | 14 |
引文计数(2018)
文献(2015-2017)
4418次引用
1032篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Hematology
|
#9/120
点击查看排名表
|
|
推荐刊物均可到国家新闻出
版总署网站查询正刊
可签署保密协议 ,不透露任
何用户信息可跟踪进程,全程
协议
1对1服务,7x24小时在线
15年经验沉淀,实体公司
运营
liting7111
liting7111
研究方向:凝血
接受率: 比较困难(25%命中)
liting7111
研究方向:医药科学 血液系统
审稿时间: 2个月内
影响因子:43.474
ISSN:1074-7613
研究方向:医学-免疫学
影响因子:2.957
ISSN:0891-6934
研究方向:医学-免疫学
影响因子:3.152
ISSN:0171-2985
研究方向:医学-免疫学
影响因子:4.04
ISSN:1750-743X
研究方向:医学-免疫学
影响因子:3.594
ISSN:1471-2172
研究方向:医学-免疫学
影响因子:2.211
ISSN:0198-8859
研究方向:医学-免疫学
影响因子:31.25
ISSN:1529-2908
研究方向:医学-免疫学
影响因子:4.23
ISSN:0165-2478
研究方向:医学-免疫学
影响因子:8.701
ISSN:1933-0219
研究方向:医学-免疫学
发表一篇学和医学成像类SCI论文
需要多少钱?
专注医学期刊服务15年
您好:请问您咨询什么等级的期刊?专注医学类期刊发表15年口碑企业,为您提供以下服务:
1.医学核心期刊发表-全流程服务
2.医学SCI期刊-全流程服务
3.论文投稿服务-快速报价
4.期刊推荐直至录用,不成功不收费
客服正在输入...
HAEMATOLOGICA 投稿经验
(由下方点评分析获得,3人参与,29022人阅读)