发表一篇学和医学成像类SCI论文
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Abstract:
:Macrophages are versatile cells that can be polarized by the tissue environment to fulfill required needs. Proinflammatory polarization is associated with increased tissue degradation and propagation of inflammation whereas alternative polarization within a Th2 cytokine environment is associated with wound healing and angiogenesis. To understand if polarization of macrophages can lead to a procoagulant macrophage subset we polarized human monocyte derived macrophages to a proinflammatory and an alternative activation state. Alternative polarization with interleukin-4 and IL-13 led to a macrophage phenotype characterized by increased tissue factor (TF) production and release and by an increase in extracellular vesicle production. In addition, also TF activity was enhanced in extracellular vesicles of alternatively polarized macrophages. This TF induction was dependent on signal transducer and activator of transcription-6 signaling and poly ADP ribose polymerase activity. In contrast to monocytes, human macrophages did not show increased tissue factor expression upon stimulation with lipopolysaccharide and interferon-γ. Previous polarization to either a proinflammatory or an alternative activation subset does not change the subsequent stimulation of TF. The inability of proinflammatory activated macrophages to respond to lipopolysaccharide and interferon-γ with an increase in TF production seems to be due to an increase in TF promoter methylation and was reversible when treating these macrophages with a demethylation agent. In conclusion, we provide evidence that proinflammatory polarization of macrophages does not lead to enhanced procoagulatory function, whereas alternative polarization of macrophages leads to an increased expression of TF and increased production of TF bearing extracellular vesicles by these cells suggesting a procoagulatory phenotype of alternatively polarized macrophages.
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最新影响因子:11.047 | 期刊ISSN:0390-6078 | CiteScore:4.28 |
出版周期: | 是否OA:YES | 出版年份:0 |
期刊官方网址:http://haematologica.org/
自引率:4.00% | 研究方向:HEMATOLOGY- |
出版地区:ITALY |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Published by Ferrata Storti Foundation. ISSN: 0390-6078.
由Ferrata Storti基金会出版。ISSN: 0390 - 6078。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
HEMATOLOGY (血液学) 2区 |
5/71 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
239 | 225 | 14 |
引文计数(2018)
文献(2015-2017)
4418次引用
1032篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Hematology
|
#9/120
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研究方向:凝血
接受率: 比较困难(25%命中)
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研究方向:医药科学 血液系统
审稿时间: 2个月内
影响因子:4.177
ISSN:1932-7447
研究方向:化学-材料科学:综合
影响因子:9.423
ISSN:1939-5116
研究方向:NANOSCIENCE & NANOTECHNOLOGY-MEDICINE, RESEARCH &
影响因子:3.641
ISSN:1550-7033
研究方向:医学-纳米科技
影响因子:1.151
ISSN:1672-0733
研究方向:医学-生化与分子生物学
影响因子:6.096
ISSN:1743-5889
研究方向:医学-纳米科技
影响因子:1
ISSN:1438-3608
研究方向:医学-精神病学
影响因子:3.523
ISSN:2072-666X
研究方向:NANOSCIENCE & NANOTECHNOLOGY-INSTRUMENTS & INSTRUM
影响因子:18.027
ISSN:1936-0851
研究方向:工程技术-材料科学:综合
影响因子:18.962
ISSN:1748-0132
研究方向:工程技术-材料科学:综合
发表一篇学和医学成像类SCI论文
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