发表一篇学和医学成像类SCI论文
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Abstract:
:The objective of the present study was to develop a novel long-acting intra-oral delivery system (LIDS) to overcome the frequent administration by the nonparenteral route with Huperzine A (HupA) as a model drug. HupA-LIDS was prepared using a magnetic drug delivery with dental resin as release controlling layer for long-term release of HupA. The factors that influenced the drug release comprised of the type and amount of pore formers, the speed of shaker, resin layer weight and drug loading. These factors were evaluated and optimized. The in-vitro release studies showed that the system was able to deliver HupA in an approximately zero-order kinetic. The SEM study showed that the multiple orifices on the surface of a resin layer formed due to presence of pore formers, which contributed to the HupA release. The pharmacokinetic study in rabbits demonstrated the HupA-LIDS could be released in vivo for more than 8 days with prolonged Tmax and significantly reduced Cmax in comparison with commercial tablets. This study provided some pioneering ideas for developing intra-oral extended release drug delivery system using dental resin as release controlling materials. The optimized HupA-LIDS can make excellent sustained release and have the potential for the long-acting product in the therapy of Alzheimer's disease.
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最新影响因子:5.112 | 期刊ISSN:0928-0987 | CiteScore:3.81 |
出版周期:Monthly | 是否OA:YES | 出版年份:1993 |
期刊官方网址:http://www.elsevier.com/wps/find/journaldescription.cws_home/523997/description
自引率:7.20% | 研究方向:医学-药学 |
出版地区:NETHERLANDS |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The European Journal of Pharmaceutical Sciences is the official journal of the European Federation for Pharmaceutical Sciences (EUFEPS). The journal publishes research reports, review articles and scientific commentaries on all aspects of the pharmaceutical sciences with strong emphasis on originality and scientific quality. The Editors welcome articles in this multidisciplinary field, ranging from drug discovery, over drug delivery to drug development. More specifically, the Journal publishes reports in medicinal chemistry, pharmacology, drug absorption and metabolism, pharmacokinetics and pharmacodynamics, pharmaceutical and biomedical analysis, drug delivery including gene delivery, drug targeting, pharmaceutical technology, pharmaceutical biotechnology and clinical drug evaluation. Scientific commentaries and review articles are generally by invitation only or by consent of the Editors. Proceedings of scientific meetings may be published as special issues or supplements to the Journal. Manuscripts submitted to the Journal are only accepted on the understanding that (a) they are subject to editorial review (generally by two independent referees); (b) they have not been, and will not be, published in whole or in part in any other journal; (c) the recommendations of the Declarations of Helsinki and Tokyo, for humans, and the European Community guidelines as accepted principles for the use of experimental animals have been adhered to.
《欧洲药物科学杂志》是欧洲药物科学联合会(EUFEPS)的官方期刊。该杂志出版的研究报告,评论文章和科学评论的所有方面的药物科学的重点创新和科学质量。编辑欢迎在这个多学科领域的文章,从药物发现,药物交付到药物开发。更具体地说,该杂志在药物化学、药理学、药物吸收和代谢、药物动力学和药效学、药物和生物医学分析、药物传递(包括基因传递、药物靶向、药物技术、药物生物技术和临床药物评价)等领域发表报告。科学评论和评论文章一般只由编辑邀请或同意。科学会议论文集可作为特刊或增刊出版。提交给《日刊》的稿件只有在下列条件下才被接受:(a)它们必须经过编辑审查(一般由两名独立审稿人审查);(b)它们尚未、也将不会全部或部分发表在任何其他期刊上;(c)《赫尔辛基宣言》和《东京关于人类的宣言》的建议以及《欧洲共同体关于使用实验动物的公认原则的准则》已得到遵守。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
PHARMACOLOGY & PHARMACY (药学) 3区 |
68/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
501 | 469 | 32 |
引文计数(2018)
文献(2015-2017)
3233次引用
849篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Pharmacology, Toxicology and Pharmaceutics
小类(学科):Pharmaceutical Science
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#18/174
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研究方向:医药科学 药物学 药剂学
审稿时间: 1个月内
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接受率: 中等(50%命中)
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研究方向:药理学 制药学 动物实验
审稿时间: 2个月内 接受率: 中等(50%命中)
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研究方向:药化 药理
审稿时间: 2个月内 接受率: 比较困难(25%命中)
影响因子:3.467
ISSN:0738-3991
研究方向:医学-公共卫生、环境卫生与职业卫生
影响因子:1.512
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影响因子:1.072
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研究方向:管理科学-统计学与概率论
影响因子:1.109
ISSN:0308-0188
研究方向:综合性期刊-综合性期刊
影响因子:1.782
ISSN:1525-822X
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影响因子:1.322
ISSN:0018-7259
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影响因子:0.478
ISSN:1369-1465
研究方向:
发表一篇学和医学成像类SCI论文
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