发表一篇学和医学成像类SCI论文
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Abstract:
:The purpose of this work was to prepare and characterize Angiopep-2 functionalized ginsenoside-Rg3 loaded nanoparticles (ANG-Rg3-NP) and evaluate the therapeutic effect on C6 glioma cells. Nanoparticles were prepared by the emulsion solvent evaporation method. Angiopep-2 was functionalized to nanoparticles via a maleimide-thiol covalent binding reaction to obtain ANG-Rg3-NP. The prepared nanoparticles were evaluated for size, zeta potential, morphology, stability, encapsulation efficiency, loading capacity, and release properties. The cytotoxicity study and targeting effect of ANG-Rg3-NP were evaluated by MTT assay. The study of cellular uptake in C6 glioma cells was performed by fluorescence microscopy and by using a microplate reader. The prepared ANG-Rg3-NP was observed to be uniformly spherical in shape with a particle size at 147.1 ± 2.7 nm. The encapsulation efficiency and loading capacity reached 80.6 ± 3.0% and 27.2 ± 1.4%, respectively. Additionally, ANG-Rg3-NP exhibited a desirable sustained release behavior. In vitro cytotoxicity study indicated that ANG-Rg3-NP could inhibit the proliferation of C6 glioma cells in a concentration-dependent manner. Also, the functionalization of Angiopep-2 made nanoparticles cross the blood-brain barrier more easily and accelerated the cellular uptake of nanoparticles. The ANG-Rg3-NP was a promising brain drug delivery carrier for the treatment of glioma.
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最新影响因子:3.915 | 期刊ISSN:1083-7450 | CiteScore:1.56 |
出版周期:Bimonthly | 是否OA:YES | 出版年份:1996 |
自引率:11.20% | 研究方向:医学-药学 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Pharmaceutical Development and Technology explores the research in the design, development, manufacture, and evaluation of traditional and novel drug delivery systems- emphasizing practical solutions and applications to theoretical and research-based problems. Through basic and applied research articles, review papers, short reports, and book reviews, Pharmaceutical Development and Technology will cover topics such as preformulation evaluation of pharmaceutical materials physical pharmacy and formulation research process engineering and scale-up of drug delivery systems drug delivery systems’ evaluation and quality improvement global standardization of pharmaceutical information.
药物开发与技术探索传统和新型药物传递系统的设计、开发、制造和评估方面的研究——强调理论和研究基础问题的实际解决方案和应用。通过基础研究和应用研究的文章,评论文章,简短的报告,和书评,医药开发和技术将涵盖的话题,例如预制剂评价物理药学和制药材料配方研究过程工程和扩大药物输送系统药物输送系统的评价和质量改进全球医药信息的标准化。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
PHARMACOLOGY & PHARMACY (药学) 4区 |
177/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
109 | 104 | 5 |
引文计数(2018)
文献(2015-2017)
552次引用
354篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Pharmacology, Toxicology and Pharmaceutics
小类(学科):Pharmaceutical Science
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#78/174
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研究方向:肿瘤转移 可变剪接
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研究方向:医药科学 药物学 药剂学
影响因子:1.714
ISSN:1386-2073
研究方向:化学-生化研究方法
影响因子:6.088
ISSN:1933-7213
研究方向:医学-神经科学
影响因子:1.379
ISSN:0362-5664
研究方向:医学-临床神经学
影响因子:4.287
ISSN:1473-7175
研究方向:CLINICAL NEUROLOGY-PHARMACOLOGY & PHARMACY
影响因子:1.821
ISSN:1528-4336
研究方向:医学-传染病学
影响因子:2.385
ISSN:1120-009X
研究方向:医学-药学
影响因子:2.706
ISSN:1076-6294
研究方向:医学-传染病学
影响因子:4.177
ISSN:1178-6973
研究方向:-
影响因子:5.758
ISSN:0305-7453
研究方向:医学-传染病学
发表一篇学和医学成像类SCI论文
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