MASTER KEY Project: Powering Clinical Development for Rare Cancers through a Platform Trial.
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Abstract:
:For rare cancers, challenges in establishing standard therapies are greater than those for major cancers and effective methods are needed. MASTER KEY project is a multicenter study based in Japan, with two main parts: prospective registry study and multiple clinical trials. Advanced rare cancers, cancers of unknown primary origin, and those with rare tissue subtypes of common cancers are targeted. The registry study accumulates highly reliable consecutive data that can be used for future drug development. The multiple trials are conducted simultaneously, targeting either a specific biomarker or a rare tumor type of interest. The first interim dataset from the registry part presented here shows the prevalence of genetic abnormalities, response rates, survival rates, and clinical trial enrollment rates. From May 2017 to April 2019, 560 patients (Mean age = 53) were enrolled in the project. Frequent cancer types included soft tissue sarcomas, neuroendocrine tumors, and CNS tumors. Among the 528 patients with assessable data, 69% (364/528) had NGS tests, with 48% (176/364) harboring an "actionable" alteration. Seventy-one (13%) patients have been enrolled in one of the clinical trials, with an accrual rate of 3.94 patients/month. A descriptive analysis of biomarker-(or non-biomarker-) directed treatment survival was performed. This project is expected to accelerate development of treatments for rare cancers and show that comprehensive platform trials are an advantageous strategy.
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CLINICAL PHARMACOLOGY & THERAPEUTICS
CLIN PHARMACOL THER
| 最新影响因子：6.903 | 期刊ISSN：0009-9236 | CiteScore：0.02 |
| 出版周期：Monthly | 是否OA：YES | 出版年份：1960 |
| 自引率：9.50% | 研究方向：医学-药学 |
| 出版地区：UNITED STATES |
SCI期刊coverage：Science Citation Index Expanded（科学引文索引扩展）
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CLINICAL PHARMACOLOGY & THERAPEUTICS 期刊简介
英文简介：
Clinical Pharmacology & Therapeutics (CPT) is the authoritative cross-disciplinary journal in experimental and clinical medicine devoted to publishing advances in the nature, action, efficacy, and evaluation of therapeutics. CPT welcomes original articles, letters and communications in the emerging areas of translational, predictive and personalized medicine; new therapeutic modalities including gene and cell therapies; pharmacogenomics, proteomics and metabolomics; bioinformation and applied systems biology complementing areas of pharmacokinetics and pharmacodynamics, human investigation and clinical trials, pharmacovigilence, pharmacoepidemiology, pharmacometrics, and population pharmacology. Commentaries and Point-Counterpoint provide a forum for perspectives in clinical pharmacology and therapeutics in the context of contemporary scientific, political, economic and social issues. State of the Art contributions summarize the latest advances in the science underpinning drug discovery, development, regulation and utilization. CPT highlights issues transforming the practice of clinical pharmacology, including ethics, education and public policy. Bench-to-bedside translation in therapeutics is presented in the context of clinical applications of basic pharmacology, discovery and translational medicine, and drug development.
中文简介：（来自Google、百度翻译）
临床药理学与治疗学(CPT)是实验医学和临床医学的权威交叉学科期刊，致力于发表治疗学的性质、作用、疗效和评价方面的进展。CPT欢迎翻译、预测和个性化医学新兴领域的原创文章、信函和通信;新的治疗方式包括基因和细胞疗法;药物基因组学、蛋白质组学和代谢组学;生物信息和应用系统生物学补充药物动力学和药效学、人体调查和临床试验、药物警戒、药物流行病学、药物计量学和人口药理学等领域。评论和观点对位提供了一个论坛的观点，临床药理学和治疗在当代科学，政治，经济和社会问题的背景下。《最新进展》综述了支持药物发现、开发、管理和利用的科学方面的最新进展。CPT强调转变临床药理学实践的问题，包括伦理、教育和公共政策。在临床应用的基础药理学，发现和翻译医学，以及药物开发的背景下，治疗的基准到床边翻译。
CLINICAL PHARMACOLOGY & THERAPEUTICS 期刊中科院评价数据
最新中科院分区
| 大类(学科) | 小类(学科) | 学科排名 |
| 医学 |
PHARMACOLOGY & PHARMACY(药理学和药剂学) 1区 |
13/261 |
最新公布的期刊年发文量
| 年度总发文量 | 年度论文发表量 | 年度综述发表量 |
| 179 | 149 | 30 |
影响因子趋势图
CLINICAL PHARMACOLOGY & THERAPEUTICS 期刊CiteScore评价数据
最新CiteScore值
引文计数(2018)
文献(2015-2017)
1次引用
63篇文献
CiteScore排名
| 序号 | 类别 | 排名 | 百分位 |
| 1 |
大类(学科)：Pharmacology, Toxicology and Pharmaceutics
小类(学科)：General Pharmacology, Toxicology and Pharmaceutics
|
#65/68
点击查看排名表
|
|
| 2 |
大类(学科)：Medicine
小类(学科)：Pharmacology (medical)
|
#217/230
点击查看排名表
|
|
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偏重的研究方向：临床药理学 (1)
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投稿录用比例：暂无
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审稿速度：平均2个月的审稿周期(非官方数据)
最新评论(不代表本站观点)
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liting7111
审稿速度说不上快，投稿后审了一个半月给拒稿了，审稿意见相当严厉。2020-06-12 -
liting7111
审稿时间： 2个月内 接受率： 比较困难（25%命中）
审了七周整，最后拒稿。审稿意见给了很多，比较专业。2020-02-04 -
liting7111
审稿时间： 2个月内 接受率： 比较困难（25%命中）
审了一个多月，提了许多问题，很苛刻，最终拒稿。稿件接受率大概在10%左右。2019-10-20 -
liting7111
研究方向：临床药理学
接受率： 比较困难（25%命中）
临床药理学方向的权威期刊，对稿件的要求很高，收稿量也不多，审稿还是比较慢的，需要交审稿费。2019-05-01
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