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Abstract:
:Neoagarooligosaccharides (NAOS) are generated by β-agarases, which cleave the β-1,4 linkage in agarose. Previously, we reported that NAOS inhibited fat accumulation in the liver and decreased serum cholesterol levels. However, the hepatoprotective effect of NAOS on acute liver injury has not yet been investigated. Thus, we examined whether NAOS could activate NF-E2-related factor 2 (Nrf2)-antioxidant response element (ARE) and upregulates its target gene, and has hepatoprotective effect in vivo. In hepatocytes, phosphorylation and subsequent nuclear translocation of Nrf2 are increased by treatment with NAOS, in a manner dependent on p38 and JNK. Consistently, NAOS augmented ARE reporter gene activity and the antioxidant protein levels, resulting in increased intracellular glutathione levels. NAOS antagonized tert-butylhydroperoxide-induced reactive oxygen species (ROS) generation. Moreover, NAOS inhibited acetaminophen (APAP)-induced serum ALT and AST and significantly decreased hepatocyte degeneration and inflammatory cell infiltration. Moreover, ROS production and glutathione depletion by APAP were reversed by NAOS. APAP-mediated apoptotic signaling pathways were also inhibited in NAOS-treated mice. Upregulalted hepatic expression of genes related to inflammation by APAP were consistently diminished by NAOS. Collectively, our results demonstrate that NAOS exhibited a hepatoprotective effect against APAP-mediated acute liver damage through its antioxidant capacity.
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最新影响因子:2.264 | 期刊ISSN:0918-6158 | CiteScore:3.23 |
出版周期:Monthly | 是否OA:YES | 出版年份:1993 |
期刊官方网址:www.jstage.jst.go.jp/browse/bpb
期刊投稿地址:http://bpb.pharm.or.jp/
自引率:7.20% | 研究方向:医学-药学 |
出版地区:JAPAN |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Classification: Biochemistry; Drugs -- pharmacology; Pharmacology; Pharmacology; Pharmacy; Toxicology.
分类:生物化学;药物——药理学;药理学;药理学;药房;毒理学。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
PHARMACOLOGY & PHARMACY(药理学和药剂学) 4区 |
198/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
311 | 283 | 28 |
引文计数(2018)
文献(2015-2017)
1526次引用
472篇文献
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1 |
大类(学科):Neuroscience
小类(学科):General Neuroscience
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#33/111
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2 |
大类(学科):Psychology
小类(学科):Neuropsychology and Physiological Psychology
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#8/58
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研究方向:人参皂苷 疲劳
接受率: 一般容易(75%命中)
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研究方向:药理
接受率: 一般容易(75%命中)
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研究方向:提取物 分析 药理
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研究方向:中药 植物提取物 药剂
接受率: 一般容易(75%命中)
影响因子:4.725
ISSN:2093-0879
研究方向:GASTROENTEROLOGY & HEPATOLOGY-CLINICAL NEUROLOGY
影响因子:31.793
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研究方向:医学-胃肠肝病学
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ISSN:0016-5085
研究方向:医学-胃肠肝病学
影响因子:1.214
ISSN:1735-143X
研究方向:医学-胃肠肝病学
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