Sodium acetate alleviated high-carbohydrate induced intestinal inflammation by suppressing MAPK and NF-κB signaling pathways in Nile tilapia (Oreochromis niloticus).

Abstract:
:With the development of aquaculture industry, high-carbohydrate diet is used to stimulate protein-sparing effect and reduce feed cost. However, fish utilize carbohydrates poorly in general, and instead, high level of carbohydrates in the diet influence the growth condition of fish. How to alleviate the side effects of high carbohydrate diet on fish health has attracted more and more attentions. In the present study, Nile tilapia (Oreochromis niloticus) were fed with 25% and 45% of carbohydrate diet for eight weeks. Higher body weight but lower resistance to pathogen was found in 45% carbohydrate diet group. Higher expression level of inflammation cytokines, increased expression of total NF-κB protein and phosphorylated NF-κB protein (p-NF-κB) were detected in higher carbohydrate group. Concentration of short-chain fatty acids (SCFAs) was measured and the results indicated that high-carbohydrate diet decreased acetate content in the intestine. In order to detect the relationship between the decreased concentration of acetate and lower resistance to pathogen in high-carbohydrate group, 45% of carbohydrate diets (HC) supplemented with different concentrations of sodium acetate (HC + LA, 100 mmol/L; HC + MA, 200 mmol/L; HC + HA, 400 mmol/L) were used to raise Nile Tilapia for eight weeks. The results indicated that addition of 200 mmol/L sodium acetate (HC + MA) reduced the mortality when fish were challenged with Aeromonas hydrophila. Furthermore, we also found that addition of 200 mmol/L sodium acetate mainly inhibited p38 mitogen-activated protein kinase (p38MAPK) and NF-κB phosphorylation to decrease the expression level of inflammation cytokines (IL-8, IL-12, TNF-α and IL-1β) in the intestine. The present study indicated that certain concentration of sodium acetate could alleviate high-carbohydrate induced intestinal inflammation mainly by suppressing MAPK activation and NF-κB phosphorylation.
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FISH & SHELLFISH IMMUNOLOGY
FISH SHELLFISH IMMUN
最新影响因子:4.622 | 期刊ISSN:1050-4648 | CiteScore:N/A |
出版周期:Monthly | 是否OA:YES | 出版年份:1991 |
期刊官方网址:http://www.sciencedirect.com/science/journal/10504648
自引率:39.20% | 研究方向:农林科学-海洋与淡水生物学 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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FISH & SHELLFISH IMMUNOLOGY 期刊简介
英文简介:
This journal rapidly publishes high-quality, peer-refereed contributions in the expanding fields of fish and shellfish immunology. It presents studies on the basic mechanisms of both the specific and non-specific defense systems, the cells, tissues, and h
中文简介:(来自Google、百度翻译)
本杂志在鱼类和贝类免疫学的扩展领域迅速发表了高质量的同行推荐贡献。它提出了对特异性和非特异性防御系统、细胞、组织的基本机制的研究。
FISH & SHELLFISH IMMUNOLOGY 期刊中科院评价数据
最新中科院分区
大类(学科) | 小类(学科) | 学科排名 |
医学 |
FISHERIES(渔业) 2区 IMMUNOLOGY(免疫学) 3区 MARINE & FRESHWATER BIOLOGY(海洋和淡水生物学) 2区 VETERINARY SCIENCES(兽医学) 1区 |
5/51 78/155 10/106 3/140 |
最新公布的期刊年发文量
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
597 | 593 | 4 |
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序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Agricultural and Biological Sciences
小类(学科):Aquatic Science
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