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Abstract:
:DNA interstrand cross-links (ICLs) are essential for the antitumor activity of chloroethylnitrosoureas (CENUs). Commonly, CENUs resistance is mainly considered to be associated with O6-methylguanine-DNA methyltransferase (MGMT) within tumors. Bypassing the MGMT-mediated resistance, to our knowledge, herein, we first utilized a novel glycolytic inhibitor, 3-bromopyruvate (3-BrPA), to increase the cytotoxic effects of l,3-bis(2-chloroethyl)-l-nitrosourea (BCNU) to human glioma cells based on the hypothesis that blocking energy metabolism renders tumor cells more sensitive to chemotherapy. We found 3-BrPA significantly increased the cell killing by BCNU in human glioma SF763 and SF126 cell lines. Significantly decreased levels of extracellular lactate, cellular ATP and glutathione (GSH) were observed after 3-BrPA treatment, and the effects were more remarkable with 3-BrPA in combination with BCNU. Considering that the role of ATP and GSH in drug efflux, DNA damage repair and drug inactivation, we determined the effect of 3-BrPA on the formation of dG-dC ICLs induced by BCNU using stable isotope dilution high-performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS). As expected, the levels of lethal dG-dC ICLs induced by BCNU were obviously enhanced after 3-BrPA pretreatment. Based on these results, 3-BrPA and related glycolytic inhibitors may be promising to enhance the cell killing effect and reverse the clinical chemoresistance of CENUs and related antitumor agents.
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最新影响因子:4.571 | 期刊ISSN:0300-483X | CiteScore:3.39 |
出版周期:Semimonthly | 是否OA:YES | 出版年份:1973 |
期刊官方网址:http://www.elsevier.com/wps/find/journaldescription.cws_home/505518/description#description
期刊投稿地址:http://ees.elsevier.com/tox/
自引率:4.10% | 研究方向:医学-毒理学 |
出版地区:NETHERLANDS |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Toxicology is a journal for the publication of original scientific papers on the biological effects arising from the administration of chemical compounds, principally to animals, tissues or cells, but also to man. Such compounds include industrial chemicals and residues, chemical contaminants, consumer products, drugs, metals, pesticides, food additives, cosmetics, and additives to animal feedstuff. Preference will be given to investigations dealing with the mechanisms of action of toxic agents. Papers describing molecular interactions with cellular and genetic processes will be welcomed.Quantitative toxicological studies will be published that are of relevance to risk assessment and regulatory management of exposure hazards and safety evaluation. This applies particularly to carcinogenicity, mutagenicity, embryotoxicity and related areas, as well as to alternatives to the use of animals in toxicological experimentation. Epidemiological studies bearing toxicological significance to man fall within the scope of the journal. The Editors also welcome the submission of concise and pertinent reviews on current issues in toxicology.IMMUNOTOXICOLOGY, a section of the journal, includes original papers and peer reviews dealing with any adverse interference of chemicals, including drugs, with the immune system: immunosuppression, hypersensitivity, auto-immunity, immune-mediated side-effects of drugs, toxicity of immunomodulating and immunotherapeutic agents. ENVIRONMENTAL AND NUTRITIONAL INTERACTIONS: A new section dedicated to original research and comprehensive critical reviews of animal as well as human and computer modeling studies of the interactions between the environment and nutrition. These include the effects of environmental changes on nutrition and food production; identification of nutrient interactions with environmentally induced disorders; the effect of nutritional status on the response to environmental stresses; and understanding the mechanisms of such interactions and their impact on human health and welfare. A list of forthcoming manuscripts is available on Internet via http://www.elsevier.nl/locate/toxicol-manuscripts.
《毒理学》是一本发表有关化学化合物(主要是对动物、组织或细胞,也包括对人)的生物效应的原始科学论文的杂志。这些化合物包括工业化学品和残留物、化学污染物、消费品、药物、金属、农药、食品添加剂、化妆品和动物饲料添加剂。将优先考虑调查有毒物质的作用机制。将欢迎描述分子与细胞和遗传过程相互作用的论文。将发表定量毒理学研究,这些研究与风险评估、暴露危险的监管管理和安全性评估有关。这尤其适用于致癌性、致突变性、胚胎毒性和相关领域,以及毒理学实验中动物使用的替代品。对人类具有毒理学意义的流行病学研究属于该杂志的范围。编辑们也欢迎就毒理学的当前问题提交简洁而有针对性的评论。免疫毒理学是该杂志的一个部分,它包括原始论文和同行评论,涉及化学物质(包括药物)对免疫系统的任何不良干扰:免疫抑制、超敏反应、自身免疫、免疫介质。药物的副作用,免疫调节剂和免疫治疗剂的毒性。环境与营养相互作用:一个新的领域,致力于对动物的原始研究和全面的批判性评论,以及对环境与营养相互作用的人类和计算机建模研究。其中包括环境变化对营养和食品生产的影响;识别营养与环境引起的疾病的相互作用;营养状况对环境压力反应的影响;理解这种相互作用的机制及其对人类健康和福利的影响。即将出版的手稿列表可通过http://www.elsevier.nl/locate/toxicol-manipscripts在互联网上查阅。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
PHARMACOLOGY & PHARMACY(药理学和药剂学) 3区 TOXICOLOGY(毒理学) 3区 |
76/261 26/94 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
185 | 176 | 9 |
引文计数(2018)
文献(2015-2017)
1561次引用
460篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Pharmacology, Toxicology and Pharmaceutics
小类(学科):Toxicology
|
#18/111
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研究方向:动物毒理 细胞毒理
审稿时间: 6个月内 接受率: 中等(50%命中)
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研究方向:医药科学 预防医学 卫生毒理
审稿时间: 1个月内
影响因子:2.995
ISSN:0028-3940
研究方向:医学-核医学
影响因子:2.324
ISSN:1051-2284
研究方向:医学-核医学
影响因子:3.156
ISSN:1869-1439
研究方向:CLINICAL NEUROLOGY-RADIOLOGY, NUCLEAR MEDICINE & M
影响因子:4.6
ISSN:0150-9861
研究方向:医学-核医学
影响因子:1.764
ISSN:1591-0199
研究方向:CLINICAL NEUROLOGY-RADIOLOGY, NUCLEAR MEDICINE & M
影响因子:4.966
ISSN:0195-6108
研究方向:医学-核医学
影响因子:3.005
ISSN:0301-0449
研究方向:医学-核医学
影响因子:2.396
ISSN:1793-5458
研究方向:OPTICS-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGI
影响因子:3.632
ISSN:1084-9785
研究方向:医学-核医学
发表一篇学和医学成像类SCI论文
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