发表一篇学和医学成像类SCI论文
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Abstract:
:Antiviral treatment could block mother-to-child transmission (MTCT) of hepatitis B virus (HBV) effectively. We examined whether maternal use of telbivudine (LdT) could decrease the proportion of CD4+CD25+ regulatory T cells and explored the immunological mechanism. A total of 89 pregnant women with HBsAg positive were enrolled, where 30 pregnant women with HBeAg negative (viral load<106 IU/ml) and the other 59 pregnant women with HBeAg positive (viral load≥106 IU/ml) were followed in the study. The women with high viral load were divided to the LdT-treated group where they were prescribed with 600mg LdT daily (29 cases) during the third trimester of pregnancy or to the non-treated group (30 cases) on a voluntary basis. Samples of neonates were taken for analyzing CD4+CD25+ Tregs with flow cytometric techniques. A more significant decrease in the proportion of CD4+CD25+Tregs in neonatal peripheral blood had been observed with maternal use of telbivudine (2.8%±1.1%) than those without any treatment (7.0%±1.6%, P< 0.01). None of the infants in the LdT-treated group were HBsAg positive at 7 months of age. In addition, neonates whose mothers received telbivudine had a significant improvement in cellular immune function, as indicated by the proportion of CD8+ T cells. For HBV carriers with high viral load, maternal use of LdT may be useful in regulating neonatal immune function involved in mother-to-child transmission of hepatitis B virus.
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最新影响因子:3.189 | 期刊ISSN:2210-7401 | CiteScore:1.86 |
出版周期: | 是否OA:YES | 出版年份:2011 |
期刊官方网址:http://www.journals.elsevier.com/clinics-and-research-in-hepatology-and-gastroenterology/
期刊投稿地址:http://ees.elsevier.com/gcb/
自引率:1.40% | 研究方向:GASTROENTEROLOGY & HEPATOLOGY- |
出版地区:FRANCE |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Clinics and Research in Hepatology and Gastroenterology has an open access mirror journal Clinics and Research in Hepatology and Gastroenterology: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Clinics and Research in Hepatology and Gastroenterology publishes high quality papers in the field of hepatology and gastroenterology in English language. The editors put the accent on rapid communication of new research and clinical developments and so called "hot topic" issues. Following a clear Editorial line, besides original articles and case reports, each issue features editorials, commentaries, a seminar, mini-reviews, pictorial reviews and several keynotes. The journal encourages research and discussion between all those involved in the specialty on an international level. Articles in press are online and indexed in the international databases (Current Contents, Pubmed, Scopus, Science Direct).
在肝病学和胃肠病学方面的诊所和研究有一个开放的镜象。杂志在肝病学和胃肠病学方面的诊所和研究:X,目标和范围相同,编辑团队,提交系统和严格的同行评审。 在肝病学和胃肠病学方面的诊所和研究发表了高质量的英语肝病学和胃肠病学领域的论文。编辑把重点放在新的研究和临床发展的快速交流上,称之为“热点”问题。除了原创文章和案例报告外,每一期都有明确的编辑路线,包括社论、评论、研讨会、小型评论、图片评论和若干要点。该期刊鼓励所有在国际层面从事这一专业的人进行研究和讨论。报刊上的文章都是在线的,并在国际数据库中进行索引(当前的内容、公开、范围、科学直接)。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
GASTROENTEROLOGY & HEPATOLOGY (胃肠肝病学) 4区 |
56/80 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
84 | 66 | 18 |
引文计数(2018)
文献(2015-2017)
800次引用
431篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Hepatology
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#35/59
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2 |
大类(学科):Medicine
小类(学科):Gastroenterology
|
#58/128
点击查看排名表
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liting7111
研究方向:消化病 胃肠道
liting7111
研究方向:腹腔镜
liting7111
研究方向:消化病 胃肠道
审稿时间: 3个月内
liting7111
研究方向:消化病 胃肠道
审稿时间: 2个月内 接受率: 一般容易(75%命中)
liting7111
研究方向:消化病 胃肠道
审稿时间: 3个月内 接受率: 一般容易(75%命中)
liting7111
审稿时间: 3个月内 接受率: 中等(50%命中)
liting7111
接受率: 比较困难(25%命中)
影响因子:2.995
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研究方向:CLINICAL NEUROLOGY-RADIOLOGY, NUCLEAR MEDICINE & M
影响因子:4.6
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影响因子:4.966
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研究方向:医学-核医学
影响因子:3.005
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影响因子:2.396
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研究方向:OPTICS-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGI
影响因子:3.632
ISSN:1084-9785
研究方向:医学-核医学
发表一篇学和医学成像类SCI论文
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