Abstract:

BACKGROUND:A watch-and-wait strategy is a nonoperative alternative to sphincter-preserving surgery for patients with locally advanced rectal cancer who achieve a clinical complete response after neoadjuvant therapy. There are limited data about bowel function for patients undergoing this organ-preservation approach. OBJECTIVE:To compare bowel function in patients with rectal cancer managed with a watch-and-wait approach to bowel function in patients who underwent sphincter-preserving surgery (total mesorectal excision). DESIGN:Retrospective case-control study employing patient-reported outcomes. SETTING:Comprehensive cancer center. PATIENTS:Twenty-one patients underwent a watch-and-wait approach and were matched 1:1 with 21 patients from a pool of 190 patients who underwent sphincter-preserving surgery, based on age, gender, and tumor distance from the anal verge. MAIN OUTCOME MEASURES:Bowel function using the Memorial Sloan Kettering Cancer Center Bowel Function Instrument. RESULTS:Patients in the watch-and-wait arm had better bowel function on the overall scale (median total score, 76 vs 55; p < 0.001) and on all subscales, with the greatest difference on the urgency/soilage subscale (median score, 20 vs 12; p < 0.001). LIMITATIONS:Retrospective design, small sample size, and temporal variability between surgery and time of questionnaire completion. CONCLUSIONS:A watch-and-wait strategy correlated with overall better bowel function when compared to sphincter-preserving surgery using a comprehensive validated bowel dysfunction tool. See Video Abstract at http://links.lww.com/DCR/B218.