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Abstract:
BACKGROUND & AIMS:There is debate over the presence and prevalence of brain injury in patients with celiac disease. To validate previous reports, we investigated the prevalence of neuropsychological dysfunction in persons with celiac disease included in the National UK Biobank, which contains experimental medical data from 500,000 adults in the United Kingdom. METHODS:Biobank participants with celiac disease (n=104; mean age, 63; 65% female) were matched with healthy individuals (controls, n=198; mean age, 63 y; 67% female) for age, sex, level of education, body mass index, and diagnosis of hypertension. All subjects were otherwise healthy. We compared scores from 5 cognitive tests, and multiple-choice responses to 6 questions about mental health, between groups using t test and χ2 analyses. Groupwise analyses of magnetic resonance imaging brain data included a study of diffusion tensor imaging metrics (mean diffusivity, fractional anisotropy, radial diffusivity, axial diffusivity), voxel-based morphometry, and Mann-Whitney U comparisons of Fazekas grades. RESULTS:Compared with controls, participants with celiac disease had significant deficits in reaction time (P=.004) and significantly higher proportions had indications of anxiety (P=.025), depression (P=.015), thoughts of self-harm (P=.025) and health-related unhappiness (P=.010). Tract-based spatial statistics analysis revealed significantly increased axial diffusivity in widespread locations, demonstrating white matter changes in brains of participants with celiac disease. Voxel-based morphometry and Fazekas grade analyses did not differ significantly between groups. CONCLUSIONS:In an analysis of data from the UK Biobank, we found participants with celiac disease to have cognitive deficit, indications of worsened mental health, and white matter changes, based on analyses of brain images. These findings support the concept that celiac disease is associated with neurological and psychological features.
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最新影响因子:46.802 | 期刊ISSN:0016-5085 | CiteScore:6.95 |
出版周期:Monthly | 是否OA:YES | 出版年份:1943 |
自引率:3.70% | 研究方向:医学-胃肠肝病学 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Gastroenterology is the most prominent journal in the field of gastrointestinal disease. As the official journal of the American Gastroenterological Association, Gastroenterology delivers up-to-date, authoritative, clinically oriented coverage of all areas in gastroenterology. Regular features include articles by leading authorities, reports on the latest treatments for diseases, and an exclusive correspondence section. Gastroenterology is organized into the following sections to make material easy to find: Alimentary Tract; Liver, Pancreas and Biliary Tract; Case Reports; Special Reports and Reviews; and a section on Clinical Challenges which presents more in-depth information on how a diagnosis is reached. An additional feature is the Image of the Month.
胃肠病学是胃肠疾病领域最著名的期刊。作为美国胃肠病学协会的官方杂志,胃肠病学提供最新的,权威的,以临床为导向的胃肠病学的所有领域的报道。定期的特写包括由权威机构撰写的文章,关于疾病的最新治疗方法的报道,以及一个独家的通讯栏目。胃肠病学分为以下几个部分,使材料容易找到:消化道;肝脏、胰腺和胆道;病例报告;特别报告和审查;还有一个关于临床挑战的章节,提供了关于如何做出诊断的更深入的信息。另外一个特性是该月的图像。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
GASTROENTEROLOGY & HEPATOLOGY(肠胃学和肝脏学) 1区 |
1/80 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
278 | 251 | 27 |
引文计数(2018)
文献(2015-2017)
13021次引用
1874篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Hepatology
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#0/59
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2 |
大类(学科):Medicine
小类(学科):Gastroenterology
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#2/128
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研究方向:淋巴瘤
接受率: 一般容易(75%命中)
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研究方向:医药科学 消化系统 肝胆胰免疫及相关疾病
审稿时间: 1个月内
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研究方向:消化病 胃肠道
接受率: 比较困难(25%命中)
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研究方向:胰腺癌
审稿时间: 2个月内 接受率: 比较困难(25%命中)
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研究方向:消化病 胃肠道
接受率: 比较困难(25%命中)
影响因子:2.816
ISSN:1520-9512
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研究方向:医学-传染病学
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影响因子:3.131
ISSN:1472-9792
研究方向:医学-呼吸系统
影响因子:2.871
ISSN:2055-1010
研究方向:PRIMARY HEALTH CARE-RESPIRATORY SYSTEM
影响因子:9.41
ISSN:0012-3692
研究方向:医学-呼吸系统
影响因子:21.405
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研究方向:医学-呼吸系统
影响因子:30.7
ISSN:2213-2600
研究方向:RESPIRATORY SYSTEM-RESPIRATORY SYSTEM
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