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Abstract:
BACKGROUND:Acute liver failure (ALF), characterized by sudden onset of coagulopathy (INR ≥ 1.5) and encephalopathy may occur during pregnancy, either as a pregnancy-associated etiology or as an unrelated and co-incidental liver injury. The U.S. Acute Liver Failure Study Group comprised of 33 tertiary care liver centers has enrolled consecutive patients with ALF or acute liver injury (ALI: INR≥ 2.0 with no encephalopathy), over two decades. METHODS:The etiologies, clinical features and outcomes of 70 of 3,155 patients (2.2%), who developed ALF or ALI during pregnancy were reviewed to determine how many were pregnancy-associated (PAALD) and how many were attributed to other etiologies. RESULTS:Thirty-five of the 70 were considered PAALD, of whom nearly half were attributed to hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome and half to acute fatty liver of pregnancy (AFLP), although in some instances the distinction was unclear. Virtually all with PAALD had been delivered prior to hepatology referral, mostly by cesarean section. Acetaminophen toxicity accounted for 21 (60% of the remaining cases), with the remainder resulting from a variety of other causes, but not including viral hepatitis A through E. Although recovery with delivery or supportive measures was possible in most cases, 11 of 70 (16%) required liver transplantation and 8 (11%) died. Swansea criteria to diagnose AFLP were met by all patients with PAALD and also by virtually all women with other forms of ALF. CONCLUSIONS:Only half of those with ALF during pregnancy appeared to have HELLP or AFLP. Morbidity and mortality for mother and fetus are strongly associated with the etiology of liver failure.
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最新影响因子:17.298 | 期刊ISSN:0270-9139 | CiteScore:6.91 |
出版周期:Monthly | 是否OA:YES | 出版年份:1981 |
期刊官方网址:http://aasldpubs.onlinelibrary.wiley.com/hub/journal/10.1002/(ISSN)1527-3350/
自引率:4.50% | 研究方向:医学-胃肠肝病学 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The premier publication in the field of liver disease, Hepatology publishes original, peer-reviewed articles concerning all aspects of liver structure, function and disease. Each month, the distinguished Editorial Board monitors and selects only the best articles on subjects such as immunology, chronic hepatitis, viral hepatitis, cirrhosis, genetic and metabolic liver diseases and their complications, liver cancer, and drug metabolism.
肝病学是肝病领域的主要出版物,它发表关于肝脏结构、功能和疾病的所有方面的原创的、经过同行评审的文章。每个月,杰出的编辑委员会只对免疫学、慢性肝炎、病毒性肝炎、肝硬化、遗传性和代谢性肝病及其并发症、肝癌和药物代谢等方面的最佳文章进行监测和选择。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
GASTROENTEROLOGY & HEPATOLOGY (胃肠肝病学) 2区 |
5/80 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
290 | 267 | 23 |
引文计数(2018)
文献(2015-2017)
12820次引用
1855篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Hepatology
|
#3/59
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研究方向:肝病
审稿时间: 2个月内 接受率: 比较困难(25%命中)
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影响因子:3.241
ISSN:0362-2436
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影响因子:1.723
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研究方向:-
影响因子:2.879
ISSN:1862-3522
研究方向:ENDOCRINOLOGY & METABOLISMORTHOPEDICS -ORTHOPEDICS
影响因子:1.004
ISSN:0085-4530
研究方向:医学-整形外科
影响因子:3.117
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研究方向:ORTHOPEDICS-
影响因子:1.345
ISSN:0147-7447
研究方向:医学-整形外科
影响因子:1.536
ISSN:0749-0712
研究方向:医学-整形外科
发表一篇学和医学成像类SCI论文
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