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Abstract:
BACKGROUND: Gastroesophageal reflux disease (GERD) is an important concern after peroral endoscopic myotomy (POEM). However, there are limited data on the risk factors for post-POEM GERD and its responsiveness to proton pump inhibitors (PPIs). In this study, we aimed to analyze the variables affecting the occurrence of GERD and its response to PPI therapy. METHODS: Consecutive patients with idiopathic achalasia who underwent POEM (December 2016 to January 2018) were evaluated for GERD using 24-hour pH impedance, esophagogastroduodenoscopy (EGD), and symptoms. Multivariate analysis was performed to identify the variables affecting the incidence of post-POEM GERD. RESULTS: A total of 209 patients with esophageal motility disorders, including 194 patients with non-sigmoid achalasia, underwent POEM during the study period. Comprehensive evaluation of GERD was completed on 167 patients (86.1 %): 47.3 % women with a mean (standard deviation) age of 41 (14.42) years and body mass index of 22.2 (3.89) kg/m2; the majority (70.7 %) were treatment naïve. A high DeMeester score (> 14.72), reflux esophagitis, and symptomatic GERD were identified in 47.9 %, 41.9 %, and 29.3 % of patients, respectively. On logistic regression analysis, type of achalasia, technique of POEM (anterior vs. posterior), pre- or post-POEM esophageal manometry variables, and patient characteristics were not associated with post-POEM GERD. Erosive esophagitis responded to PPI therapy in the majority of patients (81.4 %). CONCLUSION: The incidence of GERD is high after POEM. Most of the reflux esophagitis is mild and responsive to PPI therapy. There are no procedural or patient-related variables that appear to affect the incidence of post-POEM GERD.
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最新影响因子:9.776 | 期刊ISSN:0013-726X | CiteScore:1.49 |
出版周期:Monthly | 是否OA:YES | 出版年份:1969 |
期刊官方网址:http://endoscopy.thieme.com/
自引率:9.50% | 研究方向:医学-外科 |
出版地区:GERMANY |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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大类(学科) | 小类(学科) | 学科排名 |
医学 |
SURGERY (外科) 2区 GASTROENTEROLOGY & HEPATOLOGY (胃肠肝病学) 1区 |
11/80 5/200 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
107 | 104 | 3 |
引文计数(2018)
文献(2015-2017)
2584次引用
1730篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Gastroenterology
|
#68/128
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研究方向:临床内镜
审稿时间: 2个月内 接受率: 比较困难(25%命中)
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研究方向:医药科学 消化系统 消化系统发育异常
审稿时间: 1个月内
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研究方向:内镜
影响因子:2.293
ISSN:0962-7286
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影响因子:0.65
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影响因子:0.8
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研究方向:FISHERIES-ZOOLOGY
影响因子:0.913
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研究方向:FISHERIES-ZOOLOGY
影响因子:3.605
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研究方向:医学-动物学
影响因子:0.362
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研究方向:ZOOLOGY-
影响因子:0.653
ISSN:1525-2647
研究方向:医学-动物学
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