
发表一篇学和医学成像类SCI论文
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Abstract:
OBJECTIVE:Although perturbations in mitochondrial function and structure have been described in the intestinal epithelium of Crohn's disease and ulcerative colitis patients, the role of epithelial mitochondrial stress in the pathophysiology of inflammatory bowel diseases (IBD) is not well elucidated. Prohibitin 1 (PHB1), a major component protein of the inner mitochondrial membrane crucial for optimal respiratory chain assembly and function, is decreased during IBD. DESIGN:Male and female mice with inducible intestinal epithelial cell deletion of Phb1 (Phb1iΔIEC ) or Paneth cell-specific deletion of Phb1 (Phb1ΔPC ) and Phb1fl/fl control mice were housed up to 20 weeks to characterise the impact of PHB1 deletion on intestinal homeostasis. To suppress mitochondrial reactive oxygen species, a mitochondrial-targeted antioxidant, Mito-Tempo, was administered. To examine epithelial cell-intrinsic responses, intestinal enteroids were generated from crypts of Phb1iΔIEC or Phb1ΔPC mice. RESULTS:Phb1iΔIEC mice exhibited spontaneous ileal inflammation that was preceded by mitochondrial dysfunction in all IECs and early abnormalities in Paneth cells. Mito-Tempo ameliorated mitochondrial dysfunction, Paneth cell abnormalities and ileitis in Phb1iΔIEC ileum. Deletion of Phb1 specifically in Paneth cells (Phb1ΔPC ) was sufficient to cause ileitis. Intestinal enteroids generated from crypts of Phb1iΔIEC or Phb1ΔPC mice exhibited decreased viability and Paneth cell defects that were improved by Mito-Tempo. CONCLUSION:Our results identify Paneth cells as highly susceptible to mitochondrial dysfunction and central to the pathogenesis of ileitis, with translational implications for the subset of Crohn's disease patients exhibiting Paneth cell defects.
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最新影响因子:23.059 | 期刊ISSN:0017-5749 | CiteScore:9.82 |
出版周期:Monthly | 是否OA:YES | 出版年份:1960 |
期刊官方网址:http://gut.bmj.com/
自引率:3.20% | 研究方向:医学-胃肠肝病学 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Gut, a leading international journal in gastroenterology has an established reputation for publishing first class clinical research of the alimentary tract, the liver, biliary tree and pancreas.
《肠道》是国际领先的胃肠病学杂志,以发表消化道、肝脏、胆道和胰腺的一流临床研究而享有盛誉。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
GASTROENTEROLOGY & HEPATOLOGY(肠胃学和肝脏学) 1区 |
3/80 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
195 | 188 | 7 |
引文计数(2018)
文献(2015-2017)
8877次引用
904篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Gastroenterology
|
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研究方向:肝病 病毒性肝炎 胃肠道疾病
接受率: 比较困难(25%命中)
liting7111
研究方向:医药科学 消化系统 肝胆胰结构与功能异常
审稿时间: 2个月内
liting7111
研究方向:医药科学 消化系统 肝纤维化、肝硬化与门脉高压症
审稿时间: 1个月内
liting7111
研究方向:医药科学 消化系统
liting7111
研究方向:医药科学 消化系统 消化道结构与功能异常
审稿时间: 1个月内
liting7111
研究方向:医药科学 消化系统 肝纤维化 肝硬化 门脉高压症
审稿时间: 1个月内
liting7111
研究方向:临床
接受率: 非常困难(几乎不命中)
影响因子:2.706
ISSN:1448-5028
研究方向:医学-传染病学
影响因子:5.078
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影响因子:2.451
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研究方向:医学-传染病学
影响因子:3.926
ISSN:0195-6701
研究方向:医学-传染病学
影响因子:2.133
ISSN:1530-3667
研究方向:医学-传染病学
影响因子:2.918
ISSN:0196-6553
研究方向:医学-传染病学
影响因子:6.211
ISSN:1477-8939
研究方向:PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-INFECT
影响因子:3.718
ISSN:1876-0341
研究方向:PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -INFEC
影响因子:3.254
ISSN:0899-823X
研究方向:医学-传染病学
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