发表一篇学和医学成像类SCI论文
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Abstract:
:The co-evolving tumour cells and the systemic immune environment are mutually dysregulated. Tumours affect the immune response in a complex manner. For example, while lymphocytes are mobilized in response to tumours, their function is impaired by tumour progression. This study aimed to explore how the baseline and dynamic renal cell carcinoma (RCC) tumour burdens affect the T cell repertoire, and whether the baseline T cell receptor β chain (TCRB) diversity predicts prognosis. To characterise the TCRB repertoire, the baseline and follow-up peripheral TCRB repertoires of 45 RCC patients and two benign renal disease patients were examined using high-throughput TCRB sequencing. To explain the significance of TCRB diversity, 56 peripheral leukocyte samples from 28 patients before and after surgery were subjected to transcriptome sequencing. To validate the results, an advanced RCC patient repertoire was subjected to single cell RNA sequencing (scRNA, 10x Genomics). Higher TCRB diversity was found to be correlated with a higher lymphocyte-to-neutrophil ratio, especially indicating more naïve T cells. High baseline TCRB diversity predicted a better prognosis for stage IV patients, and different tumour burdens exerted distinct impacts on the immune status. The pre-operative TCRB diversity was significantly higher in benign and stage I (low tumour burden) RCC patients than in stage IV (high tumour burden) patients. After the tumour burden of advanced patients was mostly relieved, we observed that the TCRB diversity was restored, T cell exhaustion was reduced, and naïve T cells mobilized. It was demonstrated that the circulating TCRB repertoire could reflect the immune status and predict prognosis, and to some extent that cytoreductive nephrectomy (CN) reduces the burden of the immune system in advanced patients, which might provide a good opportunity for immunotherapy. This article is protected by copyright. All rights reserved.
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最新影响因子:9.883 | 期刊ISSN:0022-3417 | CiteScore:5.86 |
出版周期:Monthly | 是否OA:YES | 出版年份:1969 |
期刊官方网址:http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1096-9896
自引率:2.20% | 研究方向:医学-病理学 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The main interests of the Journal of Pathology lie in the pathophysiological and pathogenetic mechanisms of human disease and in the application of such knowledge to diagnosis and prognosis. In determining content the primary considerations are excellence relevance and novelty. The Journal welcomes investigative studies on human tissues experimental studies in vitro and in vivo and investigations based on animal models with a clear relevance to human disease including transgenic systems. Methodological improvements in investigative and diagnostic pathology are also of interest. Correlative studies of pathological data and clinical outcomes are encouraged but purely descriptive papers on diagnostic pathology are not considered central to the Journal's purpose. In general studies which appropriately employ multiple investigative techniques are preferred over those which rely on a single methodology. Illustrations must be of the highest quality to be acceptable for publication. As well as original research papers the Journal seeks to provide rapid publication in a variety of other formats including editorials review articles and other features both contributed and solicited. Papers covering significant developments in teaching methods and in the practice of pathology may be acceptable if they are of international scope and relevance. Correspondence from readers will be published if it is of general interest. In summary the Journal aims to serve as a bridge between basic biomedical science and clinical medicine. As a Journal of the Pathological Society of Great Britain and Ireland it seeks to reflect the broad scientific interests of the Society's membership but its ethos authorship content and purpose are those expected of a leading publication in the international scientific literature.
《病理学杂志》的主要兴趣在于人类疾病的病理生理和发病机制,以及这些知识在诊断和预后中的应用。在确定内容时,主要考虑的是卓越的相关性和新颖性。该杂志欢迎对人体组织的研究,体外和体内的实验研究,以及基于与人类疾病(包括转基因系统)有明确关联的动物模型的研究。研究性和诊断性病理学的方法改进也很有趣。鼓励对病理学数据和临床结果进行相关研究,但关于诊断病理学的纯描述性论文并不被认为是该杂志的核心目的。一般来说,适当采用多种调查方法的研究比依赖单一方法的研究更为可取。插图必须具有最高质量,才能出版。除了最初的研究论文,该杂志还寻求以各种其他形式提供快速出版,包括社论评论文章和其他既有贡献又有索取的特色。如果论文涉及到教学方法和病理学实践的重大发展,并且具有国际范围和相关性,则可以接受。如果读者的信件符合一般利益,将予以公布。总之,该杂志的目标是成为基础生物医学科学和临床医学之间的桥梁。作为大不列颠和爱尔兰病理学会的一本杂志,它试图反映该学会成员的广泛科学利益,但它的精神、作者内容和目的是国际科学文献的主要出版物。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
PATHOLOGY (病理学) 2区 ONCOLOGY (肿瘤学) 2区 |
32/223 5/79 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
142 | 137 | 5 |
引文计数(2018)
文献(2015-2017)
2919次引用
498篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Pathology and Forensic Medicine
|
#4/185
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研究方向:医药科学 肿瘤学 肿瘤发生
审稿时间: 2个月内
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研究方向:kidney tumor
接受率: 比较困难(25%命中)
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接受率: 比较困难(25%命中)
影响因子:2.438
ISSN:0261-1929
研究方向:农林科学-兽医学
影响因子:3.025
ISSN:1094-7159
研究方向:医学-临床神经学
影响因子:4.169
ISSN:0264-410X
研究方向:医学-免疫学
影响因子:17.579
ISSN:0022-1007
研究方向:医学-免疫学
影响因子:5.274
ISSN:0971-5916
研究方向:医学-免疫学
影响因子:4.061
ISSN:2314-6745
研究方向:ENDOCRINOLOGY & METABOLISM-MEDICINE, RESEARCH & EX
影响因子:2.976
ISSN:0914-8779
研究方向:医学-内分泌学与代谢
影响因子:4.75
ISSN:0141-8955
研究方向:医学-内分泌学与代谢
影响因子:10.171
ISSN:1931-5244
研究方向:医学-医学:内科
发表一篇学和医学成像类SCI论文
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