发表一篇学和医学成像类SCI论文
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Abstract:
:To identify whether platelet amyloid-β protein precursor (AβPP) ratio, phosphorylated-tau (P-tau) 231, P-tau181, and serine 396 and 404 (Ser396/404) phosphorylated tau are potential peripheral indicators for early Alzheimer's disease (AD). Forty-three amnesic mild cognitive impairment (aMCI) patients and 45 normal controls were recruited. Peripheral venous blood was drawn and platelets were collected and evaluated for potential indicators by Western blot analysis. Subsequent meta-analysis was completed on these selected indicators. In platelets of aMCI patients, the AβPP ratio level was significantly lower and levels of P-tau231 and Ser396/404 phosphorylated tau were significantly higher. Moreover, in aMCI patients, a negative correlation was observed between platelet P-tau231 level and the Trail Making Tests A score, and it was found that higher platelet P-tau231 levels significantly associated with a worse performance of information processing speed. Furthermore, values of the area under the curve of platelet P-tau231 and Ser396/404 phosphorylated tau were 0.624 and 0.657, respectively. Finally, a meta-analysis indicated platelet AβPP ratio level was significantly lower in MCI cohorts. In conclusion, platelets of aMCI subjects showed a lower AβPP ratio and higher levels of P-tau231 and Ser396/404 phosphorylated tau when compared to normal controls, which may be critical in identifying early AD.
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最新影响因子:6.591 | 期刊ISSN:1079-5006 | CiteScore:4.99 |
出版周期:Monthly | 是否OA:YES | 出版年份:1995 |
自引率:9.80% | 研究方向:医学-老年医学 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The Journals of Gerontology were the first journals on aging published in the United States. The tradition of excellence in these peer-reviewed scientific journals, established in 1946, continues today. The Journals of Gerontology Series A publishes within its covers the Journal of Gerontology: Biological Sciences and the Journal of Gerontology: Medical Sciences. JOURNAL OF GERONTOLOGY: BIOLOGICAL SCIENCES: Publishes articles on the biological aspects of aging in areas such as biochemistry, biodemography, cellular and molecular biology, comparative and evolutionary biology, endocrinology, exercise sciences, genetics, immunology, morphology, neuroscience, nutrition, pathology, pharmacology, physiology, vertebrate and invertebrate genetics, and biological underpinnings of late life diseases. JOURNAL OF GERONTOLOGY: MEDICAL SCIENCES: Publishes articles representing the full range of medical sciences pertaining to aging. Appropriate areas include, but are not limited to, basic medical science, clinical epidemiology, clinical research, and health services research for professions such as medicine, dentistry, allied health sciences, and nursing. It publishes articles on research pertinent to human biology and disease. The following types of articles are published: 1) articles reporting original research; 2) rapid communications; 3) review articles; 4) guest editorials.
《老年病学杂志》是美国首次出版的有关老龄化的杂志。这些同行评审的科学期刊于1946年建立,其优秀传统至今仍在延续。《老年学A辑》杂志在其封面上刊登了《老年学杂志:生物科学》和《老年学杂志:医学科学》。《老年学杂志:生物科学》上发表生物化学、生物显微镜、细胞和分子生物学、比较和进化生物学、内分泌学、运动科学、遗传学、免疫学、形态学、神经科学、营养学、病理学、药理学、生理学、脊椎动物和无脊椎动物遗传学,以及晚年疾病的生物学基础等领域有关衰老生物学方面的文章。《老年学杂志:医学科学》上发表代表全方位医学科学与老龄化相关的文章。适当领域包括但不限于基础医学、临床流行病学、临床研究和医疗、牙科、联合健康科学和护理等专业的卫生服务研究。它发表有关人类生物学和疾病研究的文章。发表以下类型的文章:1)报道原始研究的文章;2)快速沟通;3)评论文章;4)客座社论。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
GERONTOLOGY(老年医学) 1区 |
1/36 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
245 | 242 | 3 |
引文计数(2018)
文献(2015-2017)
3423次引用
686篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):Aging
|
#3/30
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|
2 |
大类(学科):Medicine
小类(学科):Geriatrics and Gerontology
|
#3/94
点击查看排名表
|
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研究方向:认知
审稿时间: 3个月内 接受率: 比较困难(25%命中)
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研究方向:衰老
接受率: 比较困难(25%命中)
影响因子:1.714
ISSN:1386-2073
研究方向:化学-生化研究方法
影响因子:6.088
ISSN:1933-7213
研究方向:医学-神经科学
影响因子:1.379
ISSN:0362-5664
研究方向:医学-临床神经学
影响因子:4.287
ISSN:1473-7175
研究方向:CLINICAL NEUROLOGY-PHARMACOLOGY & PHARMACY
影响因子:1.821
ISSN:1528-4336
研究方向:医学-传染病学
影响因子:2.385
ISSN:1120-009X
研究方向:医学-药学
影响因子:2.706
ISSN:1076-6294
研究方向:医学-传染病学
影响因子:4.177
ISSN:1178-6973
研究方向:-
影响因子:5.758
ISSN:0305-7453
研究方向:医学-传染病学
发表一篇学和医学成像类SCI论文
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