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Abstract:
:Leukocyte telomere length in the elderly has been positively associated with healthy living and physical activity. Factors that interfere with telomere shortening are similar to those that may be associated with decreasing functional capacity. OBJECTIVE:To investigate the relationship between mean leukocyte telomere length and functional capacity in community-dwelling elderly individuals. METHODS:This is an observational, cross-sectional, multicentric study conducted with elderly Brazilian patients. Sample characterization was performed using a sociodemographic clinical questionnaire. Telomere length was evaluated by quantitative polymerase chain reaction and functional capacity was evaluated by the Short Physical Performance Battery. RESULTS:A total of 113 elderly individuals (Age 70 ± 5.4 years; 75 women and 38 men) were enrolled in this study. Unexpectedly, it was found that lower relative telomere length was associated with better physical capacity in the global Short Physical Performance Battery score. CONCLUSION:Although telomere shortening is observed with increasing age, it is as not associated with decreased functional capacity. Functionality is broad and multidimensional, involving the connection of biopsychosocial and cultural factors. While functionality may not be considered a marker of functional aging in an elderly cohort, it can still play an important role in longitudinal studies which attempt to elucidate process theories. Future studies should employ different techniques to measure telomere lengths in subpopulations of cells.
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最新影响因子:3.192 | 期刊ISSN:1549-1684 | CiteScore:1.61 |
出版周期:Bimonthly | 是否OA:YES | 出版年份:2004 |
期刊官方网址:http://www.liebertpub.com/overview/rejuvenation-research/127/
期刊投稿地址:http://www.liebertpub.com/forauthors/rejuvenation-research/127/
自引率:25.60% | 研究方向:医学-老年医学 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Published by Mary Ann Liebert. ISSN: 1549-1684. Rejuvenation Research publishes cutting-edge research on rejuvenation therapies in the laboratory and clinic. The Journal delivers the latest information on the molecular and cellular mechanisms necessary for these therapeutic approaches to be most effective, and provides key explorations and advances that may ultimately contribute to slowing or reversing the aging process. Rejuvenation Research coverage includes: Cardiovascular aging Cell immortalization and senescence Cloning/ESCs DNA damage/repair Gene targeting, gene therapy, and genomics Growth factors Immunology Invertebrate lifespan Neurodegeneration Tissue engineering Public policy and social context
玛丽·安·利伯特出版。ISSN: 1549 - 1684。 复兴研究在实验室和临床发表关于复兴疗法的前沿研究。该杂志提供了这些治疗方法最有效的分子和细胞机制的最新信息,并提供了可能最终有助于减缓或逆转衰老过程的关键探索和进展。 复兴研究覆盖范围包括: 心血管老化 细胞永生和衰老 ESCs克隆/ DNA损伤/维修 基因定位、基因治疗和基因组学 生长因子 免疫学 无脊椎动物的寿命 神经退化 组织工程 公共政策和社会背景
大类(学科) | 小类(学科) | 学科排名 |
医学 |
GERIATRICS & GERONTOLOGY (老年医学) 3区 |
20/53 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
48 | 46 | 2 |
引文计数(2018)
文献(2015-2017)
434次引用
269篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):Aging
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#21/30
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2 |
大类(学科):Medicine
小类(学科):Geriatrics and Gerontology
|
#45/94
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研究方向:抗氧化
接受率: 一般容易(75%命中)
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研究方向:化学-生化研究方法
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研究方向:医学-临床神经学
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影响因子:4.177
ISSN:1178-6973
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影响因子:5.758
ISSN:0305-7453
研究方向:医学-传染病学
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