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Abstract:
:One of the most significant hallmarks of aging is cognitive decline. D-galactose administration may impair memory and mimic the effects of natural aging. In this study, the efficiency of goat milk to protect against memory decline was tested. Fifty-two male Sprague-Dawley rats were randomly divided into four groups: (i) control group, (ii) goat milk treated group, (iii) D-galactose treated group, and (iv) goat milk plus D-galactose treated group. Subcutaneous injections of D-galactose at 120 mg/kg and oral administrations of goat milk at 1 g/kg were chosen for the study. Goat milk and D-galactose were administered concomitantly for 6 weeks, while the control group received saline. After 6 weeks, novel object recognition and T-maze tests were performed to evaluate memory of rats. Following behavioral tests, the animals were sacrificed, and right brain homogenates were analyzed for levels of lipid peroxidation, antioxidant enzymes and neurotrophic factors. The left brain hemisphere was used for histological study of prefrontal cortex and hippocampus. There was a significant memory impairment, an increase in oxidative stress and neurodegeneration and a reduction in antioxidant enzymes and neurotrophic factors levels in the brain of D-galactose treated rats compared to controls. Goat milk treatment attenuated memory impairment induced by D-galactose via suppressing oxidative stress and neuronal damage and increasing neurotrophic factors levels, thereby suggesting its potential role as a geroprotective food.
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最新影响因子:4.284 | 期刊ISSN:1389-5729 | CiteScore:3.44 |
出版周期:Quarterly | 是否OA:YES | 出版年份:2000 |
期刊官方网址:http://www.springer.com/life+sciences/cell+biology/journal/10522
自引率:9.60% | 研究方向:医学-老年医学 |
出版地区:NETHERLANDS |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Biogerontology has now developed a solid scientific base with respect to the understanding of the phenomenon of aging. A spectrum of new and innovative strategies and approaches are being increasingly applied to modulate the process of aging at the level of cells tissues organs and organisms. Biogerontology represents this step in research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on attempts to understand prevent cure or minimize age-related impairments. The science of healthy old age requires its own platform to bring forward new ideas and to encourage the scientific publication of innovative and bold experimental manipulations in this regard. Biogerontology therefore provides a peer-reviewed forum for publishing original research data new ideas and discussions about: Modulating the aging process by physical chemical and biological means including transgenic and knockout organisms; Cell culture systems to develop new approaches and health care products for maintaining and/or recovering the lost biochemical functions; Immunology autoimmunity and infection in aging; Vertebrates invertebrates micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; Biodemography and theoretical models linking aging and survival kinetics. Biogerontology will publish: original research reports; reviews hypotheses new methods and interviews; special issues on specific topics relating to aging health and longevity.
生物老年学在对衰老现象的认识方面已经形成了坚实的科学基础。在细胞、组织、器官和生物体水平上,越来越多地采用一系列新的和创新的战略和方法来调节衰老过程。生物老年学代表了研究的这一步,其主要目标是实现健康的老年生活和延长寿命。重点是试图了解如何预防、治疗或最小化与年龄相关的损害。健康老年科学需要有自己的平台来提出新的理念,并鼓励在这方面进行创新大胆的科学出版实验操作。因此,生物老年学为发表原始研究数据提供了一个同行评议的论坛,新的想法和讨论:通过物理、化学和生物手段调节衰老过程,包括转基因和敲除生物体;细胞培养系统,开发新的方法和保健产品,以维持和/或恢复失去的生化功能;免疫、自身免疫与老年感染脊椎动物、无脊椎动物、微生物和植物,用于老化和长寿的遗传决定因素的实验研究;生物人口学和老化与存活动力学的理论模型。生物老年学将发表:原始研究报告;回顾假设、新方法和访谈;与老化、健康和长寿有关的专题。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
GERIATRICS & GERONTOLOGY (老年医学) 2区 |
13/53 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
64 | 57 | 7 |
引文计数(2018)
文献(2015-2017)
636次引用
185篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Biochemistry, Genetics and Molecular Biology
小类(学科):Aging
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#11/30
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2 |
大类(学科):Nursing
小类(学科):Gerontology
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#2/39
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3 |
大类(学科):Medicine
小类(学科):Geriatrics and Gerontology
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#11/94
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研究方向:医学 老年医学
审稿时间: 4个月内
影响因子:2.723
ISSN:0892-7936
研究方向:农林科学-兽医学
影响因子:4.908
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研究方向:农林科学-科学史与科学哲学
影响因子:1.152
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研究方向:数学-数学跨学科应用
影响因子:1.325
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研究方向:社会科学-兽医学
影响因子:2.349
ISSN:0741-1235
研究方向:社会科学-运动科学
影响因子:4.144
ISSN:0378-8733
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影响因子:2.728
ISSN:0300-7839
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影响因子:1.968
ISSN:1470-2266
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影响因子:1.322
ISSN:1466-1381
研究方向:
BIOGERONTOLOGY 投稿经验
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