
发表一篇学和医学成像类SCI论文
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Abstract:
Spinal cord injury (SCI) is a serious central nervous system trauma that leads to loss of motor and sensory functions in the SCI patients. One of the cell death mechanisms is autophagy, which is ‘self-eating’ of the damaged and misfolded proteins and nucleic acids, damaged mitochondria, and other impaired organelles for recycling of cellular building blocks. Autophagy is different from all other cell death mechanisms in one important aspect that it gives the cells an opportunity to survive or demise depending on the circumstances. Autophagy is a therapeutic target for alleviation of pathogenesis in traumatic SCI. However, functions of autophagy in traumatic SCI remain controversial. Spatial and temporal patterns of activation of autophagy after traumatic SCI have been reported to be contradictory. Formation of autophagosomes following therapeutic activation or inhibition of autophagy flux is ambiguous in traumatic SCI studies. Both beneficial and harmful outcomes due to enhancement autophagy have been reported in traumatic SCI studies in preclinical models. Only further studies will make it clear whether therapeutic activation or inhibition of autophagy is beneficial in overall outcomes in preclinical models of traumatic SCI. Therapeutic enhancement of autophagy flux may digest the damaged components of the central nervous system cells for recycling and thereby facilitating functional recovery. Many studies demonstrated activation of autophagy flux and inhibition of apoptosis for neuroprotective effects in traumatic SCI. Therapeutic induction of autophagy in traumatic SCI promotes axonal regeneration, supporting another beneficial role of autophagy in traumatic SCI. In contrast, some other studies demonstrated that disruption of autophagy flux in traumatic SCI strongly correlated with neuronal death at remote location and impaired functional recovery. This article describes our current understanding of roles of autophagy in acute and chronic traumatic SCI, cross-talk between autophagy and apoptosis, therapeutic activation or inhibition of autophagy for promoting functional recovery, and future of autophagy in traumatic SCI.
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最新影响因子:6.058 | 期刊ISSN:1673-5374 | CiteScore:1.54 |
出版周期:Monthly | 是否OA:YES | 出版年份:2006 |
期刊官方网址:http://www.nrronline.org/
自引率:14.50% | 研究方向:CELL BIOLOGY-NEUROSCIENCES |
出版地区:PEOPLES R CHINA |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Neural Regeneration Research (NRR) is a peer-reviewed open-accessed journal published with monthly. NRR aims to duly report the prospective, creative, and popular basic and clinical research in the international field of neuroregeneration. NRR focuses on rapidly publishing the articles pertaining to brain injury, spinal cord injury, peripheral nerve injury, neurodegenerative diseases, and neuroimaging, which reflect the latest progress in neuroregeneration research, and aims to highlight the unique scientific characteristics of each article. The journal publishes report or interim summary supported by NIH and other National Funds, standards and survey on neuroscience industry, meta-analysis and academic discussion on innovative technologies, methods and development ; outstanding article will be granted for rapid publication. Scope of the journal The journal will cover technical and clinical studies related to health, ethical and social issues in field of Nerve Regeneration Nervous System Physiological Phenomena. Articles with clinical interest and implications will be given preference. Neural Regeneration Research (NRR) aims to duly report the prospective, creative, and popular basic and clinical research in the international field of neuroregeneration. NRR focuses on rapidly publishing the articles pertaining to neural stem cells, nerve tissue engineering, gene therapy, neurodegenerative diseases, and neuroimaging, which reflect the latest progress in neuroregeneration research, and aims to highlight the unique scientific characteristics of each article. NRR pays great attention to the timeliness of publishing. All manuscripts accepted will be published 90–180 days from the date of submission. Areas of Interest –Brain Injuries; Spinal Cord Injuries; Peripheral Nerve Injuries; Neural Degeneration; Neuroimaging. –Treatment of CNS/PNS disorders including Stem Cells and Cell-Based therapy; Gene Therapy; Neuromodulation; Tissue Engineering; Biomaterials; Pharmacological treatment; Neural prostheses and other exciting topics in the field. –Neuronal injury and regeneration from a cellular to molecular perspective, including Axonal regeneration, neuroplasticity, neural repair and replacement, neural circuit or network construction, neuromodulation or signaling repair, nerve transplantation, and neurosynaptogenesis.
神经再生研究(NRR)是一个同行评审开放访问的期刊,每月出版。NRR旨在适时报道国际神经再生领域的前瞻性、创造性和流行的基础和临床研究。NRR关注于快速发表有关脑损伤、脊髓损伤、周围神经损伤、神经退行性疾病和神经成像的文章,反映了神经再生研究的最新进展,旨在突出每一篇文章的独特科学特征。 由NIH和其他国家基金支持的期刊发表报告或中期摘要,关于神经科学行业的标准和调查,关于创新技术、方法和发展的元分析和学术讨论;尚未发表的文章将被迅速出版。 期刊的范围 该期刊将涵盖有关神经再生神经系统生理现象领域的健康、伦理和社会问题的技术和临床研究。有临床兴趣和意义的文章将优先考虑。 神经再生研究(NRR)旨在适时报道国际神经再生领域的前瞻性、创造性和流行性的基础和临床研究。NRR关注于快速发表有关神经干细胞、神经组织工程、基因治疗、神经退行性疾病和神经成像的文章,这些文章反映了神经再生研究的最新进展,旨在突出每一篇文章的独特科学特征。NRR非常重视出版的及时性。接受的所有手稿将在提交之日起90-180天内出版。 感兴趣的领域 脑损伤;脊髓损伤;周围神经损伤;神经退化;神经成像。 --包括干细胞和细胞治疗在内的CNS/PNS疾病治疗;基因治疗;神经调节;组织工程;生物材料;药理治疗;神经假体和该领域的其他令人兴奋的课题。 神经损伤和从细胞到分子的再生,包括轴突再生、神经可塑性、神经修复和置换、神经回路或网络构建、神经调节或信号修复、神经移植和神经突触发生。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
CELL BIOLOGY (细胞生物学) 4区 NEUROSCIENCES (神经科学) 4区 |
142/190 183/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
269 | 173 | 96 |
引文计数(2018)
文献(2015-2017)
1956次引用
1268篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Neuroscience
小类(学科):Developmental Neuroscience
|
#26/33
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研究方向:神经再生 神经退行性病变 帕金森
审稿时间: 3个月内 接受率: 一般容易(75%命中)
影响因子:5.315
ISSN:0148-396X
研究方向:医学-临床神经学
影响因子:1.725
ISSN:0028-3770
研究方向:医学-临床神经学
影响因子:2.21
ISSN:1878-8750
研究方向:CLINICAL NEUROLOGY-SURGERY
影响因子:4.332
ISSN:1092-0684
研究方向:CLINICAL NEUROLOGY-SURGERY
影响因子:2.816
ISSN:0001-6268
研究方向:医学-临床神经学
影响因子:2.8
ISSN:0344-5607
研究方向:医学-临床神经学
影响因子:0.972
ISSN:1019-5149
研究方向:医学-临床神经学
影响因子:1.532
ISSN:0256-7040
研究方向:医学-临床神经学
影响因子:1.165
ISSN:1016-2291
研究方向:医学-临床神经学
Neural Regeneration Research 投稿经验
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