
发表一篇学和医学成像类SCI论文
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Abstract:
Currently, there is no effective strategy to promote functional recovery after a spinal cord injury. Collagen scaffolds can not only provide support and guidance for axonal regeneration, but can also serve as a bridge for nerve regeneration at the injury site. They can additionally be used as carriers to retain mesenchymal stem cells at the injury site to enhance their effectiveness. Hence, we hypothesized that transplanting human umbilical cord-mesenchymal stem cells on collagen scaffolds would enhance healing following acute complete spinal cord injury. Here, we test this hypothesis through animal studies and a phase I clinical trial. (1) Animal experiments: Models of completely transected spinal cord injury were established in rats and canines by microsurgery. Mesenchymal stem cells derived from neonatal umbilical cord tissue were adsorbed onto collagen scaffolds and surgically implanted at the injury site in rats and canines; the animals were observed after 1 week–6 months. The transplantation resulted in increased motor scores, enhanced amplitude and shortened latency of the motor evoked potential, and reduced injury area as measured by magnetic resonance imaging. (2) Phase I clinical trial: Forty patients with acute complete cervical injuries were enrolled at the Characteristic Medical Center of Chinese People’s Armed Police Force and divided into two groups. The treatment group (n = 20) received collagen scaffolds loaded with mesenchymal stem cells derived from neonatal umbilical cord tissues; the control group (n = 20) did not receive the stem-cell loaded collagen implant. All patients were followed for 12 months. In the treatment group, the American Spinal Injury Association scores and activities of daily life scores were increased, bowel and urinary functions were recovered, and residual urine volume was reduced compared with the pre-treatment baseline. Furthermore, magnetic resonance imaging showed that new nerve fiber connections were formed, and diffusion tensor imaging showed that electrophysiological activity was recovered after the treatment. No serious complication was observed during follow-up. In contrast, the neurological functions of the patients in the control group were not improved over the follow-up period. The above data preliminarily demonstrate that the transplantation of human umbilical cord-mesenchymal stem cells on a collagen scaffold can promote the recovery of neurological function after acute spinal cord injury. In the future, these results need to be confirmed in a multicenter, randomized controlled clinical trial with a larger sample size. The clinical trial was approved by the Ethics Committee of the Characteristic Medical Center of Chinese People’s Armed Police Force on February 3, 2016 (approval No. PJHEC-2016-A8). All animal experiments were approved by the Ethics Committee of the Characteristic Medical Center of Chinese People’s Armed Police Force on May 20, 2015 (approval No. PJHEC-2015-D5).
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最新影响因子:6.058 | 期刊ISSN:1673-5374 | CiteScore:1.54 |
出版周期:Monthly | 是否OA:YES | 出版年份:2006 |
期刊官方网址:http://www.nrronline.org/
自引率:14.50% | 研究方向:CELL BIOLOGY-NEUROSCIENCES |
出版地区:PEOPLES R CHINA |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Neural Regeneration Research (NRR) is a peer-reviewed open-accessed journal published with monthly. NRR aims to duly report the prospective, creative, and popular basic and clinical research in the international field of neuroregeneration. NRR focuses on rapidly publishing the articles pertaining to brain injury, spinal cord injury, peripheral nerve injury, neurodegenerative diseases, and neuroimaging, which reflect the latest progress in neuroregeneration research, and aims to highlight the unique scientific characteristics of each article. The journal publishes report or interim summary supported by NIH and other National Funds, standards and survey on neuroscience industry, meta-analysis and academic discussion on innovative technologies, methods and development ; outstanding article will be granted for rapid publication. Scope of the journal The journal will cover technical and clinical studies related to health, ethical and social issues in field of Nerve Regeneration Nervous System Physiological Phenomena. Articles with clinical interest and implications will be given preference. Neural Regeneration Research (NRR) aims to duly report the prospective, creative, and popular basic and clinical research in the international field of neuroregeneration. NRR focuses on rapidly publishing the articles pertaining to neural stem cells, nerve tissue engineering, gene therapy, neurodegenerative diseases, and neuroimaging, which reflect the latest progress in neuroregeneration research, and aims to highlight the unique scientific characteristics of each article. NRR pays great attention to the timeliness of publishing. All manuscripts accepted will be published 90–180 days from the date of submission. Areas of Interest –Brain Injuries; Spinal Cord Injuries; Peripheral Nerve Injuries; Neural Degeneration; Neuroimaging. –Treatment of CNS/PNS disorders including Stem Cells and Cell-Based therapy; Gene Therapy; Neuromodulation; Tissue Engineering; Biomaterials; Pharmacological treatment; Neural prostheses and other exciting topics in the field. –Neuronal injury and regeneration from a cellular to molecular perspective, including Axonal regeneration, neuroplasticity, neural repair and replacement, neural circuit or network construction, neuromodulation or signaling repair, nerve transplantation, and neurosynaptogenesis.
神经再生研究(NRR)是一个同行评审开放访问的期刊,每月出版。NRR旨在适时报道国际神经再生领域的前瞻性、创造性和流行的基础和临床研究。NRR关注于快速发表有关脑损伤、脊髓损伤、周围神经损伤、神经退行性疾病和神经成像的文章,反映了神经再生研究的最新进展,旨在突出每一篇文章的独特科学特征。 由NIH和其他国家基金支持的期刊发表报告或中期摘要,关于神经科学行业的标准和调查,关于创新技术、方法和发展的元分析和学术讨论;尚未发表的文章将被迅速出版。 期刊的范围 该期刊将涵盖有关神经再生神经系统生理现象领域的健康、伦理和社会问题的技术和临床研究。有临床兴趣和意义的文章将优先考虑。 神经再生研究(NRR)旨在适时报道国际神经再生领域的前瞻性、创造性和流行性的基础和临床研究。NRR关注于快速发表有关神经干细胞、神经组织工程、基因治疗、神经退行性疾病和神经成像的文章,这些文章反映了神经再生研究的最新进展,旨在突出每一篇文章的独特科学特征。NRR非常重视出版的及时性。接受的所有手稿将在提交之日起90-180天内出版。 感兴趣的领域 脑损伤;脊髓损伤;周围神经损伤;神经退化;神经成像。 --包括干细胞和细胞治疗在内的CNS/PNS疾病治疗;基因治疗;神经调节;组织工程;生物材料;药理治疗;神经假体和该领域的其他令人兴奋的课题。 神经损伤和从细胞到分子的再生,包括轴突再生、神经可塑性、神经修复和置换、神经回路或网络构建、神经调节或信号修复、神经移植和神经突触发生。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
CELL BIOLOGY (细胞生物学) 4区 NEUROSCIENCES (神经科学) 4区 |
142/190 183/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
269 | 173 | 96 |
引文计数(2018)
文献(2015-2017)
1956次引用
1268篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Neuroscience
小类(学科):Developmental Neuroscience
|
#26/33
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研究方向:神经再生 神经退行性病变 帕金森
审稿时间: 3个月内 接受率: 一般容易(75%命中)
影响因子:5.576
ISSN:0885-3924
研究方向:医学-临床神经学
影响因子:6.005
ISSN:0192-415X
研究方向:医学-全科医学与补充医学
影响因子:202.731
ISSN:0140-6736
研究方向:医学-医学:内科
影响因子:2.898
ISSN:1807-5932
研究方向:医学-医学:内科
影响因子:1.817
ISSN:0025-7974
研究方向:医学-医学:内科
影响因子:3.006
ISSN:2044-6055
研究方向:MEDICINE, GENERAL & INTERNAL-
影响因子:0.834
ISSN:0020-9554
研究方向:医学-医学:内科
影响因子:0.522
ISSN:1108-4189
研究方向:MEDICINE, GENERAL & INTERNAL-
影响因子:11.15
ISSN:1741-7015
研究方向:医学-医学:内科
Neural Regeneration Research 投稿经验
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