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发表一篇学和医学成像类SCI论文
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Abstract:
:Purpose: Myasthenia gravis (MG) is an autoimmune disease and closely related to thymoma. Inflammatory myopathy may accompany with other autoimmune diseases. However, concurrence of inflammatory myopathy and MG is very rare. Necrotizing autoimmune myopathy (NAM), a rare form of inflammatory myopathy, is characterized by necrosis and regeneration of myocytes in proximal muscles without significant inflammation. The aim of the study was to report a rare case of NAM and concomitant thymoma-associated MG after thymectomy.Materials and methods/results: A 27-year-old female patient presented with muscle soreness and weakness in four limbs. Eyelid fatigue and neostigmine tests were negative, and no ptosis was found but the electromyographic examination (EMG) showed myogenic damage and a gradual decrease in the amplitude (20%) of EMG activities evoked by repetitive electrical stimulation. Antibodies against AChR and increased titer of creatine kinase were detected and plaque-like signals in both legs were found in magnetic resonance imaging. Myositis-related antibodies were negative but necrotic myocytes without inflammatory cell infiltration, and MHC-1 positive muscle fibers were found in muscle biopsy. Pathological examination confirmed anterior mediastinal B2 type thymoma. Five weeks after thymectomy, she started to show typical MG symptoms. No recurrence of thymoma was found but immunoassay showed a higher titer of AChR-Ab. Myositis-related antibodies negative necrotizing autoimmune myopathy (NAM) was reported to be associated with thymoma-associated MG.Conclusions: The patient showed symptoms related NAM but developed MG-related symptoms only after thymectomy. The mechanisms for the phenomena may be related to immune dysfunction associated with thymoma.
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最新影响因子:2.59 | 期刊ISSN:0020-7454 | CiteScore:1.72 |
出版周期:Monthly | 是否OA:YES | 出版年份:1970 |
自引率:2.30% | 研究方向:医学-神经科学 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The International Journal of Neuroscience publishes papers, reviews, letters to the editor, comments and notes concerned with problems of nervous tissue, the nervous system, and behavior. It deals not only with the obvious areas of neuroanatomy, neurophysiology, neurochemistry, neuropharmacology, and neuroendocrinology, but all impinging and related areas of mathematics, physics, physical chemistry, biochemistry, biophysics, bioengineering, communication and information, learning, memory, conditioning, and higher behavioral considerations. Both theoretical and experimental approaches are adopted, in particular those leading toward clarification of existing data, formation of new concepts and development of new tools for investigation (such as new mathematics, new theories of thermodynamics, etc.). In addition, the journal includes announcements and notes of events occurring in various parts of the world of significance to neuroscience.
《国际神经科学杂志》发表有关神经组织、神经系统和行为问题的论文、评论、给编辑的信、评论和笔记。它不仅涉及神经解剖学、神经生理学、神经化学、神经药理学和神经内分泌学等明显领域,而且涉及数学、物理、物理化学、生物化学、生物物理学、生物工程、通信与信息、学习、记忆、调节和更高层次的行为考虑等所有相互影响和相关的领域。采用理论和实验两种方法,特别是那些有助于澄清现有数据、形成新概念和开发用于研究的新工具(如新数学、新热力学理论等)的方法。此外,该杂志还包括世界各地发生的对神经科学具有重要意义的事件的公告和说明。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
NEUROSCIENCES (神经科学) 4区 |
208/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
150 | 137 | 13 |
引文计数(2018)
文献(2015-2017)
726次引用
422篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Neuroscience
小类(学科):General Neuroscience
|
#66/111
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研究方向:医学-计算机:跨学科应用
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