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Abstract:
PURPOSE:Mitochondrial dysfunction is a prominent feature of Alzheimer's disease (AD). As vascular endothelial growth factor (VEGF) has been shown to be protective in AD, the aim of this study was to investigate the effects of VEGF on mitochondrial function in models of AD. MATERIALS AND METHODS:Adeno associated virus (AAV)-VEGF was injected into the hippocampus of APP/PS1 mice. Cognitive function was assessed in these mice with use of the Morris water maze (MWM) and β-amyloid (Aβ) levels in the hippocampus were also measured. Cell viability and reactive oxygen species (ROS) levels were determined in the SH-SY5Y cells treated with Aβ25-35 which served as a cell model of AD. Transmission electron microscopy (TEM) was used to evaluate structural changes in mitochondria and mitochondrial DNA (mtDNA) copy number and mitochondrial membrane potential (MMP) were also recorded. Finally, we investigated the effects of VEGF upon mitochondrial biogenesis, autophagy and mitochondrial autophagy (mitophagy) as determined both in vivo and in vitro with western blots. RESULTS:VEGF treated mice showed improvements in spatial learning and memory along with reduced Aβ levels. VEGF protected SH-SY5Y cells against Aβ25-35 induced neurotoxicity as demonstrated by increased cell viability and decreased ROS production.Associated with these effects were improvements in mitochondrial structure and function, and increased numbers of mitochondria resulting from stimulation of mitochondrial biogenesis. CONCLUSIONS:VEGF alleviates Aβ related patholoy in models of AD. In part, these beneficial effects of VEGF result from protection of mitochondria and stimulation of mitochondrial biogenesis.
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最新影响因子:2.59 | 期刊ISSN:0020-7454 | CiteScore:1.72 |
出版周期:Monthly | 是否OA:YES | 出版年份:1970 |
自引率:2.30% | 研究方向:医学-神经科学 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The International Journal of Neuroscience publishes papers, reviews, letters to the editor, comments and notes concerned with problems of nervous tissue, the nervous system, and behavior. It deals not only with the obvious areas of neuroanatomy, neurophysiology, neurochemistry, neuropharmacology, and neuroendocrinology, but all impinging and related areas of mathematics, physics, physical chemistry, biochemistry, biophysics, bioengineering, communication and information, learning, memory, conditioning, and higher behavioral considerations. Both theoretical and experimental approaches are adopted, in particular those leading toward clarification of existing data, formation of new concepts and development of new tools for investigation (such as new mathematics, new theories of thermodynamics, etc.). In addition, the journal includes announcements and notes of events occurring in various parts of the world of significance to neuroscience.
《国际神经科学杂志》发表有关神经组织、神经系统和行为问题的论文、评论、给编辑的信、评论和笔记。它不仅涉及神经解剖学、神经生理学、神经化学、神经药理学和神经内分泌学等明显领域,而且涉及数学、物理、物理化学、生物化学、生物物理学、生物工程、通信与信息、学习、记忆、调节和更高层次的行为考虑等所有相互影响和相关的领域。采用理论和实验两种方法,特别是那些有助于澄清现有数据、形成新概念和开发用于研究的新工具(如新数学、新热力学理论等)的方法。此外,该杂志还包括世界各地发生的对神经科学具有重要意义的事件的公告和说明。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
NEUROSCIENCES (神经科学) 4区 |
208/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
150 | 137 | 13 |
引文计数(2018)
文献(2015-2017)
726次引用
422篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Neuroscience
小类(学科):General Neuroscience
|
#66/111
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研究方向:脑小血管病 认知障碍
审稿时间: 3个月内 接受率: 中等(50%命中)
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研究方向:抑郁症
审稿时间: 3个月内 接受率: 中等(50%命中)
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审稿时间: 3个月内 接受率: 一般容易(75%命中)
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研究方向:临床
接受率: 一般容易(75%命中)
影响因子:1.992
ISSN:1976-1457
研究方向:NUTRITION & DIETETICS-
影响因子:1
ISSN:0139-3006
研究方向:农林科学-食品科技
影响因子:3.221
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研究方向:FOOD SCIENCE & TECHNOLOGY-NUTRITION & DIETETICS
影响因子:3.467
ISSN:0738-3991
研究方向:医学-公共卫生、环境卫生与职业卫生
影响因子:9.298
ISSN:1930-7381
研究方向:医学-内分泌学与代谢
影响因子:4.807
ISSN:1662-4025
研究方向:医学-内分泌学与代谢
影响因子:4.725
ISSN:2044-4052
研究方向:ENDOCRINOLOGY & METABOLISM-NUTRITION & DIETETICS
影响因子:1.417
ISSN:1575-0922
研究方向:-
影响因子:5.551
ISSN:0307-0565
研究方向:医学-内分泌学与代谢
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