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Abstract:
PURPOSE:Mitochondrial dysfunction is a prominent feature of Alzheimer's disease (AD). As vascular endothelial growth factor (VEGF) has been shown to be protective in AD, the aim of this study was to investigate the effects of VEGF on mitochondrial function in models of AD. MATERIALS AND METHODS:Adeno associated virus (AAV)-VEGF was injected into the hippocampus of APP/PS1 mice. Cognitive function was assessed in these mice with use of the Morris water maze (MWM) and β-amyloid (Aβ) levels in the hippocampus were also measured. Cell viability and reactive oxygen species (ROS) levels were determined in the SH-SY5Y cells treated with Aβ25-35 which served as a cell model of AD. Transmission electron microscopy (TEM) was used to evaluate structural changes in mitochondria and mitochondrial DNA (mtDNA) copy number and mitochondrial membrane potential (MMP) were also recorded. Finally, we investigated the effects of VEGF upon mitochondrial biogenesis, autophagy and mitochondrial autophagy (mitophagy) as determined both in vivo and in vitro with western blots. RESULTS:VEGF treated mice showed improvements in spatial learning and memory along with reduced Aβ levels. VEGF protected SH-SY5Y cells against Aβ25-35 induced neurotoxicity as demonstrated by increased cell viability and decreased ROS production.Associated with these effects were improvements in mitochondrial structure and function, and increased numbers of mitochondria resulting from stimulation of mitochondrial biogenesis. CONCLUSIONS:VEGF alleviates Aβ related patholoy in models of AD. In part, these beneficial effects of VEGF result from protection of mitochondria and stimulation of mitochondrial biogenesis.
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最新影响因子:2.457 | 期刊ISSN:0020-7454 | CiteScore:1.72 |
出版周期:Monthly | 是否OA:YES | 出版年份:1970 |
自引率:2.30% | 研究方向:医学-神经科学 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The International Journal of Neuroscience publishes papers, reviews, letters to the editor, comments and notes concerned with problems of nervous tissue, the nervous system, and behavior. It deals not only with the obvious areas of neuroanatomy, neurophysiology, neurochemistry, neuropharmacology, and neuroendocrinology, but all impinging and related areas of mathematics, physics, physical chemistry, biochemistry, biophysics, bioengineering, communication and information, learning, memory, conditioning, and higher behavioral considerations. Both theoretical and experimental approaches are adopted, in particular those leading toward clarification of existing data, formation of new concepts and development of new tools for investigation (such as new mathematics, new theories of thermodynamics, etc.). In addition, the journal includes announcements and notes of events occurring in various parts of the world of significance to neuroscience.
《国际神经科学杂志》发表有关神经组织、神经系统和行为问题的论文、评论、给编辑的信、评论和笔记。它不仅涉及神经解剖学、神经生理学、神经化学、神经药理学和神经内分泌学等明显领域,而且涉及数学、物理、物理化学、生物化学、生物物理学、生物工程、通信与信息、学习、记忆、调节和更高层次的行为考虑等所有相互影响和相关的领域。采用理论和实验两种方法,特别是那些有助于澄清现有数据、形成新概念和开发用于研究的新工具(如新数学、新热力学理论等)的方法。此外,该杂志还包括世界各地发生的对神经科学具有重要意义的事件的公告和说明。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
NEUROSCIENCES(神经系统科学) 4区 |
208/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
150 | 137 | 13 |
引文计数(2018)
文献(2015-2017)
726次引用
422篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Neuroscience
小类(学科):General Neuroscience
|
#66/111
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研究方向:脑小血管病 认知障碍
审稿时间: 3个月内 接受率: 中等(50%命中)
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研究方向:抑郁症
审稿时间: 3个月内 接受率: 中等(50%命中)
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审稿时间: 3个月内 接受率: 一般容易(75%命中)
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研究方向:临床
接受率: 一般容易(75%命中)
影响因子:2.816
ISSN:1520-9512
研究方向:医学-呼吸系统
影响因子:2.373
ISSN:1027-3719
研究方向:医学-传染病学
影响因子:3.039
ISSN:8755-6863
研究方向:医学-呼吸系统
影响因子:2.726
ISSN:1526-0542
研究方向:医学-呼吸系统
影响因子:3.131
ISSN:1472-9792
研究方向:医学-呼吸系统
影响因子:2.871
ISSN:2055-1010
研究方向:PRIMARY HEALTH CARE-RESPIRATORY SYSTEM
影响因子:9.41
ISSN:0012-3692
研究方向:医学-呼吸系统
影响因子:21.405
ISSN:0020-1324
研究方向:医学-呼吸系统
影响因子:30.7
ISSN:2213-2600
研究方向:RESPIRATORY SYSTEM-RESPIRATORY SYSTEM
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