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Abstract:
:The cognitive role of the cerebellum has recently gained much attention, and its pivotal role in Alzheimer's disease (AD) has now been widely recognized. Diffusion tensor imaging (DTI) has been used to evaluate the disruption of the microstructural milieu in AD, and though several white matter (WM) tracts such as corpus callosum, inferior and superior longitudinal fasciculus, cingulum, fornix, and uncinate fasciculus have been evaluated in AD, data on cerebellar WM tracts are currently lacking. We performed a tractography-based DTI reconstruction of the middle cerebellar peduncle (MCP), and the left and right superior cerebellar peduncles separately (SCPL and SCPR) and addressed the differences in fractional anisotropy (FA), axial diffusivity (Dax), radial diffusivity (RD), and mean diffusivity (MD) in the three tracts between 50 patients with AD and 25 healthy subjects. We found that AD patients showed a lower FA and a higher RD compared to healthy subjects in MCP, SCPL, and SCPR. Moreover, a higher MD was found in SCPR and SCPL and a higher Dax in SCPL. This result is important as it challenges the traditional view that WM bundles in the cerebellum are unaffected in AD and might identify new targets for therapeutic interventions.
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最新影响因子:4.671 | 期刊ISSN:1387-2877 | CiteScore: |
出版周期:Semimonthly | 是否OA:YES | 出版年份:1998 |
期刊官方网址:http://www.j-alz.com/
期刊投稿地址:http://www.j-alz.com/submit
自引率:11.70% | 研究方向:医学-神经科学 |
出版地区:NETHERLANDS |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Published by IOS Press. ISSN: 1387-2877. The Journal of Alzheimer's Disease is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease. The journal publishes research reports, reviews, short communications, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease.
由IOS出版社出版。ISSN: 1387 - 2877。 《阿尔茨海默病杂志》是一份国际性的多学科期刊,旨在促进对阿尔茨海默病的病因、发病机制、流行病学、遗传学、行为、治疗和心理学的理解。该杂志出版研究报告、评论、简短的交流、书评和给编辑的信件。该杂志致力于为原始研究提供一个开放的论坛,将加快我们对阿尔茨海默病的基本认识。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
NEUROSCIENCES(神经系统科学) 3区 |
96/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
736 | 660 | 76 |
引文计数(2018)
文献(2015-2017)
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研究方向:阿尔兹海默症 病理
接受率: 比较困难(25%命中)
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研究方向:神经生物学
接受率: 比较困难(25%命中)
影响因子:3.825
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研究方向:OPTICS-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGI
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研究方向:医学-核医学
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JOURNAL OF ALZHEIMERS DISEASE 投稿经验
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