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Abstract:
BACKGROUND:Alzheimer's disease (AD) is the most common form of dementia. It is mainly characterized by a progressive deterioration of cognition, but sleep-wake cycle disturbances frequently occur. Irregular sleep-wake cycle, insomnia, and daytime napping usually occur in patients with AD in the course of the disease. OBJECTIVE:The aim of the present study was to verify the sleep-wake cycle in mild to moderate AD patients compared to controls, and to evaluate the relationship between the sleep-wake cycle impairment and the neuropsychological testing, CSF AD biomarkers, and CSF orexin concentrations. METHODS:Mild to moderate AD patients were enrolled and underwent 14-day actigraphic recording, sleep diary, neuropsychological testing, and CSF biomarkers analysis. All patients were compared to controls. RESULTS:Eighteen AD patients were compared to ten controls. AD patients showed the alteration of the sleep-wake cycle, featured by sleep dysregulation and daytime wake fragmentation, with respect to controls. Considering the correlation analysis, we documented the correlation between tau proteins and orexin CSF levels and sleep-wake cycle dysregulation. CONCLUSION:This study confirmed the dysregulation of sleep-wake cycle in AD patients, as reflected by the daytime wake fragmentation, irregular sleep-wake rhythm, and nocturnal sleep impairment. This sleep-wake cycle disorder correlates with AD neuropathological in vivo features and brain orexin activity. Hence, we suppose that a more marked AD pathology coupled with orexinergic system dysregulation may promote sleep-wake cycle impairment in AD patients.
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最新影响因子:3.909 | 期刊ISSN:1387-2877 | CiteScore: |
出版周期:Semimonthly | 是否OA:YES | 出版年份:1998 |
期刊官方网址:http://www.j-alz.com/
期刊投稿地址:http://www.j-alz.com/submit
自引率:11.70% | 研究方向:医学-神经科学 |
出版地区:NETHERLANDS |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Published by IOS Press. ISSN: 1387-2877. The Journal of Alzheimer's Disease is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease. The journal publishes research reports, reviews, short communications, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease.
由IOS出版社出版。ISSN: 1387 - 2877。 《阿尔茨海默病杂志》是一份国际性的多学科期刊,旨在促进对阿尔茨海默病的病因、发病机制、流行病学、遗传学、行为、治疗和心理学的理解。该杂志出版研究报告、评论、简短的交流、书评和给编辑的信件。该杂志致力于为原始研究提供一个开放的论坛,将加快我们对阿尔茨海默病的基本认识。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
NEUROSCIENCES(神经系统科学) 3区 |
96/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
736 | 660 | 76 |
引文计数(2018)
文献(2015-2017)
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研究方向:阿尔兹海默症 病理
接受率: 比较困难(25%命中)
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研究方向:神经生物学
接受率: 比较困难(25%命中)
影响因子:1.195
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研究方向:-
影响因子:5.439
ISSN:0305-7453
研究方向:医学-传染病学
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