发表一篇学和医学成像类SCI论文
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Abstract:
BACKGROUND:Diagnosis of Alzheimer's disease (AD) confirmed by biomarkers allows the patient to make important life decisions. However, doubt about the fleetness of symptoms progression and future cognitive decline remains. Neuropsychological measures were extensively studied in prediction of time to conversion to dementia for mild cognitive impairment (MCI) patients in the absence of biomarker information. Similar neuropsychological measures might also be useful to predict the progression to dementia in patients with MCI due to AD. OBJECTIVE:To study the contribution of neuropsychological measures to predict time to conversion to dementia in patients with MCI due to AD. METHODS:Patients with MCI due to AD were enrolled from a clinical cohort and the effect of neuropsychological performance on time to conversion to dementia was analyzed. RESULTS:At baseline, converters scored lower than non-converters at measures of verbal initiative, non-verbal reasoning, and episodic memory. The test of non-verbal reasoning was the only statistically significant predictor in a multivariate Cox regression model. A decrease of one standard deviation was associated with 29% of increase in the risk of conversion to dementia. Approximately 50% of patients with more than one standard deviation below the mean in the z score of that test had converted to dementia after 3 years of follow-up. CONCLUSION:In MCI due to AD, lower performance in a test of non-verbal reasoning was associated with time to conversion to dementia. This test, that reveals little decline in the earlier phases of AD, appears to convey important information concerning conversion to dementia.
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最新影响因子:4.16 | 期刊ISSN:1387-2877 | CiteScore: |
出版周期:Semimonthly | 是否OA:YES | 出版年份:1998 |
期刊官方网址:http://www.j-alz.com/
期刊投稿地址:http://www.j-alz.com/submit
自引率:11.70% | 研究方向:医学-神经科学 |
出版地区:NETHERLANDS |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Published by IOS Press. ISSN: 1387-2877. The Journal of Alzheimer's Disease is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease. The journal publishes research reports, reviews, short communications, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease.
由IOS出版社出版。ISSN: 1387 - 2877。 《阿尔茨海默病杂志》是一份国际性的多学科期刊,旨在促进对阿尔茨海默病的病因、发病机制、流行病学、遗传学、行为、治疗和心理学的理解。该杂志出版研究报告、评论、简短的交流、书评和给编辑的信件。该杂志致力于为原始研究提供一个开放的论坛,将加快我们对阿尔茨海默病的基本认识。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
NEUROSCIENCES (神经科学) 3区 |
96/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
736 | 660 | 76 |
引文计数(2018)
文献(2015-2017)
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研究方向:阿尔兹海默症 病理
接受率: 比较困难(25%命中)
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研究方向:神经生物学
接受率: 比较困难(25%命中)
影响因子:0.753
ISSN:0534-0012
研究方向:AGRONOMY-GENETICS & HEREDITY
影响因子:1.282
ISSN:0037-5349
研究方向:农林科学-林学
影响因子:3.017
ISSN:1364-6745
研究方向:医学-临床神经学
影响因子:3.469
ISSN:1475-2875
研究方向:医学-寄生虫学
影响因子:0.735
ISSN:0972-9062
研究方向:INFECTIOUS DISEASES-PARASITOLOGY
影响因子:0.209
ISSN:0125-1562
研究方向:PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-INFECT
影响因子:1.794
ISSN:0142-6338
研究方向:医学-热带医学
影响因子:0.828
ISSN:0049-4755
研究方向:医学-公共卫生、环境卫生与职业卫生
影响因子:3.918
ISSN:1360-2276
研究方向:医学-公共卫生、环境卫生与职业卫生
发表一篇学和医学成像类SCI论文
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