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Uric Acid and High-Density Lipoprotein Cholesterol Are Differently Associated with Alzheimer's Disease and Vascular Dementia.
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Abstract:
:Uric acid (UA) is a major contributor to naturally-occurring antioxidant activity and is thought to have protective effects against neurodegenerative processes. However, UA is also implicated as a risk factor in vascular, including cerebrovascular, disease. Its association with, and role in, dementia and its component diseases including Alzheimer's disease (AD) and vascular dementia (VaD) remains unclear and inconsistently studied. Changes in blood lipids, particularly cholesterol measures, have also been implicated in dementias although the relationship or interactions with UA have been little studied.We have measured plasma UA and lipids taken from 187 subjects first attending a general hospital neurology department for symptoms associated with dementia, and from a series of 79 healthy control subjects. Diagnoses of AD and VaD were made following neuroimaging; laboratory measures were compared between dementia and control groups and between AD and VaD subgroups. No overall change in UA was seen in dementia, although a substantial and highly significant reduction was found in the AD patients. Reduced values in total cholesterol, HDL, and LDL were found in dementia, independent of statin treatment. Further investigation found a significant reduction of HDL only in the VaD group, while total cholesterol was significantly reduced in both AD and VaD subjects.These findings indicate that in our Chinese sample, UA deficits are specifically associated with AD, while deficits in HDL cholesterol found in dementia tend to be greater in VaD.
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JOURNAL OF ALZHEIMERS DISEASE
J ALZHEIMERS DIS
| 最新影响因子：4.16 | 期刊ISSN：1387-2877 | CiteScore： |
| 出版周期：Semimonthly | 是否OA：YES | 出版年份：1998 |
期刊官方网址：http://www.j-alz.com/
期刊投稿地址：http://www.j-alz.com/submit
| 自引率：11.70% | 研究方向：医学-神经科学 |
| 出版地区：NETHERLANDS |
SCI期刊coverage：Science Citation Index Expanded（科学引文索引扩展）
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JOURNAL OF ALZHEIMERS DISEASE 期刊简介
英文简介：
Published by IOS Press. ISSN: 1387-2877. The Journal of Alzheimer's Disease is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease. The journal publishes research reports, reviews, short communications, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease.
中文简介：（来自Google、百度翻译）
由IOS出版社出版。ISSN: 1387 - 2877。 《阿尔茨海默病杂志》是一份国际性的多学科期刊，旨在促进对阿尔茨海默病的病因、发病机制、流行病学、遗传学、行为、治疗和心理学的理解。该杂志出版研究报告、评论、简短的交流、书评和给编辑的信件。该杂志致力于为原始研究提供一个开放的论坛，将加快我们对阿尔茨海默病的基本认识。
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JOURNAL OF ALZHEIMERS DISEASE 期刊中科院评价数据
最新中科院分区
| 大类(学科) | 小类(学科) | 学科排名 |
| 医学 |
NEUROSCIENCES (神经科学) 3区 |
96/261 |
最新公布的期刊年发文量
| 年度总发文量 | 年度论文发表量 | 年度综述发表量 |
| 736 | 660 | 76 |
总被引频次：20383
特征因子：0.041470
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liting7111
研究方向：阿尔兹海默症 病理
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审稿速度块，一审一个月就回来了，意见也很中肯，二审修回三天就接收，pubmed上也能很快的搜索到。2020-01-28 -
liting7111
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阿尔兹海默病方向，审稿很快，一个月不到就给了审稿结果，大修修回就接收了。审稿人给的建议相当中肯，杂志效率也很高，推荐大家投稿。2019-06-22
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