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Loss of presynaptic inhibition for step initiation in parkinsonian individuals with freezing of gait.

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Abstract:

KEY POINTS:Individuals with freezing of gait (FoG) due to Parkinson's disease (PD) have small and long anticipatory postural adjustments (APA) associated with delayed step initiation. Individuals with FoG (freezers) may require functional reorganization of spinal mechanisms to perform APAs due to supraspinal dysfunction. As presynaptic inhibition (PSI) is centrally modulated to allow execution of supraspinal motor commands, it may be deficient in freezers during APAs. We show that freezers presented PSI in quiet stance (control task), but they presented loss of PSI (i.e. higher ratio of the conditioned H-reflex relative to the test H-reflex) during APAs prior to step initiation (functional task), whereas non-freezers and healthy control individuals presented PSI in both the tasks. The loss of PSI in freezers was associated with both small APA amplitudes and FoG severity. We hypothesize that loss of PSI during APA for step initiation in freezers may be due to FoG. ABSTRACT:Freezing of gait (FoG) in Parkinson's disease involves deficient anticipatory postural adjustments (APAs) resulting in cessation of step initiation due to supraspinal dysfunction. Individuals with FoG (freezers) may require functional reorganization of spinal mechanisms to perform APAs. As presynaptic inhibition (PSI) is centrally modulated to allow execution of supraspinal motor commands, here we hypothesized a loss of PSI in freezers during APA for step initiation, which would be associated with FoG severity. Seventy individuals (27 freezers, 22 non-freezers, and 21 age-matched healthy controls [HC]) performed a GO-commanded step initiation task on a force platform under 3 conditions: 1) without electrical stimulation; 2) test Hoffman reflex (H-reflex); and 3) conditioned H-reflex. They also performed a control task (quiet stance). In the step initiation task, the H-reflexes were evoked on the soleus muscle when the amplitude of the APA exceeded 10-20% of the mean of the baseline mediolateral force. PSI was quantified by the ratio of the conditioned H-reflex relative to the test H-reflex in both the tasks. Objective assessment of FoG severity (FoG-ratio) was performed. Freezers presented lower PSI levels during quiet stance than non-freezers and HC (P<0.05). During step initiation, freezers presented loss of PSI and lower APA amplitudes than non-freezers and HC (P<0.05). Significant correlations were only found for freezers between loss of PSI and FoG-ratio (r = 0.59, P = 0.0005) and loss of PSI and APA amplitude (r = -0.35, P < 0.036). Our findings suggest that loss of PSI for step initiation in freezers may be due to FoG. This article is protected by copyright. All rights reserved.

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JOURNAL OF PHYSIOLOGY-LONDON

J PHYSIOL-LONDON
最新影响因子:4.547 期刊ISSN:0022-3751 CiteScore:
出版周期:Semimonthly 是否OA:YES 出版年份:1878

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自引率:8.80% 研究方向:医学-神经科学
出版地区:ENGLAND

SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)

NCBI查询:PubMed Central (PMC)链接全文检索(pubmed central)

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JOURNAL OF PHYSIOLOGY-LONDON 期刊简介

英文简介:

Published by Cambridge University Press. ISSN (printed): 0022-3751. ISSN (electronic): 1469-7793. Published for The Physiological Society The policy of The Journal of Physiology

中文简介:(来自Google、百度翻译)

由剑桥大学出版社出版。ISSN(印刷):0022-3751。ISSN(电子):1469-7793。 为生理学会出版的《生理学杂志》政策

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10/83

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JOURNAL OF PHYSIOLOGY-LONDON 投稿经验

(由下方点评分析获得,2人参与,643人阅读)

最新评论(不代表本站观点)

  • avatar

    liting7111

    研究方向:医药科学 神经系统 精神疾病 认知功能障碍

    审稿时间: 2个月内

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    2020-06-20
  • avatar

    liting7111

    研究方向:医药科学 神经系统 精神疾病 躯体感觉、疼痛与镇痛

    审稿时间: 1个月内

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    2020-01-23

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