发表一篇学和医学成像类SCI论文
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Abstract:
KEY POINTS:Individuals with freezing of gait (FoG) due to Parkinson's disease (PD) have small and long anticipatory postural adjustments (APA) associated with delayed step initiation. Individuals with FoG (freezers) may require functional reorganization of spinal mechanisms to perform APAs due to supraspinal dysfunction. As presynaptic inhibition (PSI) is centrally modulated to allow execution of supraspinal motor commands, it may be deficient in freezers during APAs. We show that freezers presented PSI in quiet stance (control task), but they presented loss of PSI (i.e. higher ratio of the conditioned H-reflex relative to the test H-reflex) during APAs prior to step initiation (functional task), whereas non-freezers and healthy control individuals presented PSI in both the tasks. The loss of PSI in freezers was associated with both small APA amplitudes and FoG severity. We hypothesize that loss of PSI during APA for step initiation in freezers may be due to FoG. ABSTRACT:Freezing of gait (FoG) in Parkinson's disease involves deficient anticipatory postural adjustments (APAs) resulting in cessation of step initiation due to supraspinal dysfunction. Individuals with FoG (freezers) may require functional reorganization of spinal mechanisms to perform APAs. As presynaptic inhibition (PSI) is centrally modulated to allow execution of supraspinal motor commands, here we hypothesized a loss of PSI in freezers during APA for step initiation, which would be associated with FoG severity. Seventy individuals (27 freezers, 22 non-freezers, and 21 age-matched healthy controls [HC]) performed a GO-commanded step initiation task on a force platform under 3 conditions: 1) without electrical stimulation; 2) test Hoffman reflex (H-reflex); and 3) conditioned H-reflex. They also performed a control task (quiet stance). In the step initiation task, the H-reflexes were evoked on the soleus muscle when the amplitude of the APA exceeded 10-20% of the mean of the baseline mediolateral force. PSI was quantified by the ratio of the conditioned H-reflex relative to the test H-reflex in both the tasks. Objective assessment of FoG severity (FoG-ratio) was performed. Freezers presented lower PSI levels during quiet stance than non-freezers and HC (P<0.05). During step initiation, freezers presented loss of PSI and lower APA amplitudes than non-freezers and HC (P<0.05). Significant correlations were only found for freezers between loss of PSI and FoG-ratio (r = 0.59, P = 0.0005) and loss of PSI and APA amplitude (r = -0.35, P < 0.036). Our findings suggest that loss of PSI for step initiation in freezers may be due to FoG. This article is protected by copyright. All rights reserved.
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自引率:8.80% | 研究方向:医学-神经科学 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Published by Cambridge University Press. ISSN (printed): 0022-3751. ISSN (electronic): 1469-7793. Published for The Physiological Society The policy of The Journal of Physiology
由剑桥大学出版社出版。ISSN(印刷):0022-3751。ISSN(电子):1469-7793。 为生理学会出版的《生理学杂志》政策
大类(学科) | 小类(学科) | 学科排名 |
医学 |
PHYSIOLOGY (生理学) 2区 NEUROSCIENCES (神经科学) 2区 |
58/261 10/83 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
438 | 376 | 62 |
引文计数(2018)
文献(2015-2017)
次引用
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研究方向:医药科学 神经系统 精神疾病 认知功能障碍
审稿时间: 2个月内
liting7111
研究方向:医药科学 神经系统 精神疾病 躯体感觉、疼痛与镇痛
审稿时间: 1个月内
影响因子:6.497
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研究方向:医学-精神病学
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研究方向:医学-精神病学
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影响因子:5.345
ISSN:1398-5647
研究方向:医学-精神病学
影响因子:3.492
ISSN:1540-2002
研究方向:CLINICAL NEUROLOGY-PSYCHIATRY
影响因子:4.562
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研究方向:医学-精神病学
影响因子:6.533
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研究方向:医学-精神病学
影响因子:5.415
ISSN:0924-977X
研究方向:医学-精神病学
影响因子:2.493
ISSN:0925-4927
研究方向:医学-精神病学
发表一篇学和医学成像类SCI论文
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