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Abstract:
:The drugs currently available for treating epilepsy are only partially effective in managing this condition. Therefore, it is crucial to investigate new pathways that induce and promote epilepsy development. Previously, we found that platelets interact with neuronal glycolipids and actively secrete pro-inflammatory mediators during central nervous system (CNS) pathological conditions such as neuroinflammation and traumatic brain injury (TBI). These factors increase the permeability of the blood-brain barrier (BBB), which may create a predisposition to epileptic seizures. In this study, we demonstrated that platelets substantially enhanced epileptic seizures in a mouse model of pentylenetetrazole (PTZ) -induced seizures. We found that platelets actively secreted serotonin, contributed to increased BBB permeability, and were present in the CNS parenchyma during epileptic seizures. Furthermore, platelets directly stimulated neuronal electric activity and induced the expression of specific genes related to early neuronal response, neuroinflammation, and oxidative phosphorylation, leading to oxidative stress in neurons. The intracranial injection of physiological numbers of platelets that mimicked TBI-associated bleeding was sufficient to induce severe seizures, which resembled conventional PTZ-induced epileptic activity. These findings highlight a conceptually new role of platelets in the development of epileptic seizures, and indicate a potential new therapeutic approach targeting platelets to prevent and treat epilepsy.
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最新影响因子:10.885 | 期刊ISSN:0301-0082 | CiteScore:13.59 |
出版周期:Monthly | 是否OA:YES | 出版年份:1973 |
期刊官方网址:http://www.journals.elsevier.com/progress-in-neurobiology/
期刊投稿地址:https://www.evise.com/evise/faces/pages/login/login.jspx?resourceUrl=%2Ffaces%2Fpages%2Fnavigation%2
自引率:2.70% | 研究方向:医学-神经科学 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
专业编辑在线一对一答疑及时解决您的问题
Progress in Neurobiology is designed to help individuals keep abreast of advances in knowledge in the broad field of neurosciences through the publication of comprehensive reviews by leading researchers. It will include the application of neurophysiological, biochemical, pharmacological, molecular biological, anatomical, and behavioral analyses to problems of molecular, cellular, developmental, and systems neuroscience. Special attention will be given to those areas where availability of new techniques has led to a multi-disciplinary approach to the problems of the nervous system. It is the intention of the Editor-in-Chief that the reviews should be of sufficient clarity to be suitable for assimilation by doctoral and postdoctoral students as well as by research scientists in neuroscience and allied fields. The authorship is international.
神经生物学的进展旨在帮助个人跟上先进的知识,在广泛的神经科学领域通过出版综合评论领先的研究人员。它将包括神经生理学、生物化学、药理学、分子生物学、解剖学和行为分析的应用,以解决分子、细胞、发育和系统神经科学的问题。将特别注意那些新技术的可用性已导致对神经系统问题采取多学科方法的领域。总编辑的意图是,综述应足够清晰,以适应博士和博士后学生,以及神经科学和相关领域的研究科学家的同化。作者是国际的。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
NEUROSCIENCES (神经科学) 1区 |
8/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
78 | 14 | 64 |
引文计数(2018)
文献(2015-2017)
1971次引用
145篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Neuroscience
小类(学科):General Neuroscience
|
#4/111
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影响因子:2.567
ISSN:1471-2431
研究方向:PEDIATRICS-
发表一篇学和医学成像类SCI论文
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