发表一篇学和医学成像类SCI论文
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Abstract:
:Medial temporal lobe epilepsy (MTLE) is among the most common and most drug-resistant types of epilepsies associated with remodeling of the trisynaptic circuit of the hippocampus. The cornu ammonis (CA)3 region, as the "pacemaker" of the circuit, and CA3 → CA1 synapse (Schaffer collaterals) are potential targets for suppression of MTLE. We examined optogenetic manipulation of CA3 neurons in controlling the perforant pathway kindled seizures. One week after implantation of stimulating electrodes in perforant pathway, a recording electrode in CA1, and an optic fiber in CA3, rats underwent rapid kindling procedure. A lentivector with capability to move in retrograde monosynaptic direction and to insert the gene of red light sensitive opsin Jaws in neurons was injected into CA1 of the kindled rats. One week later, the kindled rats were stimulated at afterdischarge (AD) threshold under red light illumination to CA3; and duration of AD (ADD), generalized seizures (S5D), and total seizure behavior (SD) were recorded. Encoding Jaws in CA1, CA3, and entorhinal neuronal cells of the vector injected rats was verified by immunohistochemistry. More than 90% of CA1, CA3, and entorhinal neurons of the counted sections expressed Jaws. Red light (625 nm) illumination to CA3 of the kindled rats expressing Jaws entirely suppressed generalized seizures and significantly diminished ADD and SD. Encoding the light-sensitive chloride pump Jaws in the CA3, is an efficient optogenetic strategy to stop perforant pathway kindled seizures.
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最新影响因子:5.62 | 期刊ISSN:0014-4886 | CiteScore:4.51 |
出版周期:Monthly | 是否OA:YES | 出版年份:1959 |
期刊官方网址:http://ees.elsevier.com/yexnr/default.asp?pg=login.asp
期刊投稿地址:http://ees.elsevier.com/yexnr/default.asp?pg=login.asp
自引率:3.00% | 研究方向:医学-神经科学 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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As one of the premier review journals in the neurosciences, Molecular Neurobiology is specifically designed to synthesize and critically assess research trends in experimental and clinical neuroscience at the molecular level. Its distinguished editorial board is comprised of four Nobelists and other preeminent neuroscientists who carefully review papers to ensure their high quality.
分子神经生物学是神经科学领域最重要的评论期刊之一,是专门为在分子水平上综合和批判性地评估实验和临床神经科学的研究趋势而设计的。其杰出的编辑委员会由四名诺贝尔奖获得者和其他杰出的神经科学家组成,他们仔细审查论文以确保其高质量。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
NEUROSCIENCES (神经科学) 2区 |
60/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
218 | 179 | 39 |
引文计数(2018)
文献(2015-2017)
3681次引用
817篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Neuroscience
小类(学科):Neurology
|
#18/142
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2 |
大类(学科):Neuroscience
小类(学科):Developmental Neuroscience
|
#5/33
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研究方向:神经系统疾病
接受率: 中等(50%命中)
影响因子:5.576
ISSN:0885-3924
研究方向:医学-临床神经学
影响因子:6.005
ISSN:0192-415X
研究方向:医学-全科医学与补充医学
影响因子:202.731
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研究方向:医学-医学:内科
影响因子:2.898
ISSN:1807-5932
研究方向:医学-医学:内科
影响因子:1.817
ISSN:0025-7974
研究方向:医学-医学:内科
影响因子:3.006
ISSN:2044-6055
研究方向:MEDICINE, GENERAL & INTERNAL-
影响因子:0.834
ISSN:0020-9554
研究方向:医学-医学:内科
影响因子:0.522
ISSN:1108-4189
研究方向:MEDICINE, GENERAL & INTERNAL-
影响因子:11.15
ISSN:1741-7015
研究方向:医学-医学:内科
发表一篇学和医学成像类SCI论文
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