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Abstract:
BACKGROUND:Prolonged intermittent theta burst stimulation (piTBS) with triple doses of the standard protocol is an updated form of repetitive transcranial magnetic stimulation, and it is an effective add-on intervention for major depressive disorder. In the present study, our objective was to investigate the antidepressant efficacy of piTBS monotherapy. Efficacy between the standard 5-cm method and magnetic resonance imaging (MRI)-guided coil positioning to the left dorsolateral prefrontal cortex method was also compared. METHODS:In the present double-blind, randomized, sham-controlled trial, 105 patients with recurrent depression who exhibited no responses to at least one adequate antidepressant treatment for the prevailing episode were assigned randomly to one of three groups: piTBS monotherapy (n = 35), repetitive transcranial magnetic stimulation monotherapy (n = 35), or sham stimulation (n = 35). The acute treatment period was 2 weeks. Half of the patients were randomized to MRI navigation in each group. RESULTS:No serious adverse events were observed. The piTBS group exhibited significantly greater decreases in depression scores than the sham group at week 2 (-40.0% vs. -13.9%; p < .001 after correcting for multiple comparisons by Bonferroni [effect size (Cohen's d) = 1.12]), and the odds ratio for responses was high. The MRI navigation method (-32.4%) did not yield better antidepressant effects than the standard method (-40.6%). Brain stimulation and 17-item Hamilton Depression Rating Scale changes in the first week were the most important variables for predicting antidepressant responses. CONCLUSIONS:Left prefrontal piTBS monotherapy is effective for the treatment of recurrent depression, and the MRI-guided method of coil targeting is not better than the standard method.
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最新影响因子:12.81 | 期刊ISSN:0006-3223 | CiteScore:6.96 |
出版周期:Semimonthly | 是否OA:YES | 出版年份:0 |
期刊官方网址:http://www.journals.elsevier.com/biological-psychiatry/
自引率:3.20% | 研究方向:医学-精神病学 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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This international rapid-publication journal, sponsored by the Society of Biological Psychiatry, covers the whole range of psychiatric neuroscience. Both basic and clinical contributions are encouraged from all disciplines and research areas relevant to the pathophysiology and treatment of major neuropsychiatric disorders. Full-length and Brief Reports of novel results, Case Studies of unusual significance, and Correspondence and Comments judged to be of high impact to the field are published, particularly those addressing genetic and environmental risk factors, neural circuitry and neurochemistry, and important new therapeutic approaches. Concise Reviews and Editorials, generally invited by the Editors, which focus on topics of current research and interest, are also rapidly published. Visit the web site of the Society of Biological Psychiatry at URL: http://www.sobp.org/ for details on membership, publications, awards and other society information. Visit the journal's web site at URL: http://www.elsevier.com/locate/biopsych! Related ProductAnnouncing a new CD-ROM Click above for a free demo and for further information!
这本由生物精神病学协会主办的国际快速出版期刊涵盖了精神病学神经科学的全部领域。鼓励所有学科和研究领域对主要神经精神疾病的病理生理学和治疗的基础和临床贡献。发表了关于新结果的完整和简短的报告,具有特殊意义的案例研究,以及被认为对该领域具有高度影响的通信和评论,特别是那些涉及遗传和环境风险因素、神经回路和神经化学以及重要的新治疗方法的报告。一般由编辑邀请的简明评论和社论也迅速发表,这些评论和社论集中于当前研究和感兴趣的主题。请访问生物精神病学协会的网站网址:http://www.sobp.org/,了解会员、出版物、奖项和其他社会信息的详细信息。访问该杂志的网址:http://www.elsevier.com/locate/biopsych!相关产品宣布一个新的CD-ROM点击以上免费演示和进一步的信息!
大类(学科) | 小类(学科) | 学科排名 |
医学 |
NEUROSCIENCES (神经科学) 1区 PSYCHIATRY (精神病学) 1区 |
9/261 6/142 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
179 | 146 | 33 |
引文计数(2018)
文献(2015-2017)
6473次引用
930篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Neuroscience
小类(学科):Biological Psychiatry
|
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