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Abstract:
OBJECTIVE:Sex plays an important role in many diseases. The purpose of current study is to explore whether there are different lesion patterns in the RSN functional connections between males and females with MCI progression, and identify the differences in brain network changes due to sex. METHODS:Resting state fMRI data included 37 normal controls (NC), 39 early MCI (EMCI) patients and 37 late MCI (LMCI) patients were collected, and network model based on graph theory was performed to compare the differences of brain network at different stages caused by sex from three aspects: functional connectivity between ROIs, intra-functional connectivity within RSN and inter-functional connectivity between RSN and white matter (WM). RESULTS:Sex plays a role in the changes of RSN functional connectivity, including the default mode network (DMN), the sensory-motor network (SMN), the dorsal attention network (DAN) and the executive control network (CON). The female SMN is more vulnerable and the damage of functional connectivity between DAN and WM is more serious. CONCLUSIONS:There are different lesion patterns in the RSN functional connections between males and females in the progression of MCI, which suggests that we should take full account of sex differences when conducting MCI progress studies and developing more effective biomarkers to promote the progress of cognitive impairment and dementia.
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最新影响因子:3.197 | 期刊ISSN:0304-3940 | CiteScore:2.25 |
出版周期:Weekly | 是否OA:YES | 出版年份:1975 |
期刊官方网址:http://www.journals.elsevier.com/neuroscience-letters/
期刊投稿地址:http://ees.elsevier.com/nsl/default.asp?pg=preRegistration.asp
自引率:3.60% | 研究方向:医学-神经科学 |
出版地区:NETHERLANDS |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The journal provides a rapid publication of short, complete reports, but not preliminary communications, in all areas in the fields of neuroanatomy, neurochemistry, neuroendocrinology, neuropharmacology, neurophysiology, neurotoxicology, molecular neurobiology, behavioural sciences, biocybernetics and clinical neurobiology.The over-riding criteria for publication are novelty and interest to a multidisciplinary audience. Neuroscience Letters is not a repository for material which, although sound, is neither particularly novel nor meriting urgent publication. Papers not sufficiently substantiated by experimental detail will not be published. Authors will be required where appropriate to show that they have paid attention to the guidelines in the Editorial: ethical principles for the maintenance and use of animals in neuroscience research, published in Neuroscience Letters, Vol.73, 1987, p.1. Any technical queries arising will be referred back to the author, although the Editors reserve the right to make alterations in the text without altering the technical content. Submission of a paper to Neuroscience Letters implies that it is not being submitted for publication elsewhere. Manuscripts submitted under multiple authorship are reviewed on the assumption that all listed authors concur with the submission and that a copy of the final manuscript has been approved by all authors and tacitly or explicitly by the responsible authorities in the laboratories where the work was carried out. If accepted, the manuscript shall not be published elsewhere in the same form, in either the same or another language, without the consent of the Editors and Publisher.
该杂志为神经解剖学、神经化学、神经内分泌学、神经药理学、神经生理学、神经毒理学、分子神经生物学、行为科学、生物细胞学和临床神经生物学领域的所有领域提供了简短而完整的报告,但没有提供初步的交流。出版的首要标准是多学科读者的新颖性和兴趣。神经科学信件并不是一个存储材料的仓库,尽管它听起来并不特别新颖,也不值得紧急出版。未经实验细节充分证实的论文将不予发表。在适当的情况下,作者将被要求表明他们已经注意了发表在《神经科学研究中维护和使用动物的伦理原则》社论中的指导方针,发表在《神经科学快报》1987年第73卷第1页。如有任何技术上的疑问,我们将向作者提出,但编辑保留在不改变技术内容的情况下修改文本的权利。向《神经科学快报》提交一篇论文意味着它不会在其他地方发表。以多重作者身份提交的稿件将在假定所有列出的作者都同意提交的情况下进行审查,并且最终稿件的副本已得到所有作者的批准,并已由进行工作的实验室的主管当局默认或明确地批准。未经编辑出版者同意,稿件不得在其他地方以相同的形式、相同的文字或者其他文字发表。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
NEUROSCIENCES (神经科学) 4区 |
188/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
706 | 680 | 26 |
引文计数(2018)
文献(2015-2017)
4992次引用
2215篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Neuroscience
小类(学科):General Neuroscience
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#55/111
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影响因子:1.754
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影响因子:0.321
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发表一篇学和医学成像类SCI论文
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