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Abstract:
:Here, we investigated the participation of pro and anti-inflammatory cytokines in the spread of repeated audiogenic seizures from brainstem auditory structures to limbic areas, including the hippocampus. We used Wistar Audiogenic Rats (WARs) and Wistars submitted to the audiogenic kindling protocol with a loud broad-band noise. We measured pro and anti-inflammatory cytokines and nitrate levels in the hippocampus of stimulated animals. Our results show that all WARs developed audiogenic seizures that evolved to limbic seizures whereas seizure-resistant controls did not present any seizures. However, regardless of seizure severity, we did not observe differences in the pro inflammatory cytokines IL-1β, IL-6, TNF-α and IFN-α or in the anti-inflammatory IL-10 in the hippocampi of audiogenic and resistant animals. We also did not find any differences in nitrate content. Our data indicate that the spread of seizures during the audiogenic kindling is not dependent on hippocampal release of cytokines or oxidative stress, but the severity of brainstem seizures will be higher in animals with higher levels of cytokines and the oxidative stress marker, nitrate.
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最新影响因子:3.197 | 期刊ISSN:0304-3940 | CiteScore:2.25 |
出版周期:Weekly | 是否OA:YES | 出版年份:1975 |
期刊官方网址:http://www.journals.elsevier.com/neuroscience-letters/
期刊投稿地址:http://ees.elsevier.com/nsl/default.asp?pg=preRegistration.asp
自引率:3.60% | 研究方向:医学-神经科学 |
出版地区:NETHERLANDS |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The journal provides a rapid publication of short, complete reports, but not preliminary communications, in all areas in the fields of neuroanatomy, neurochemistry, neuroendocrinology, neuropharmacology, neurophysiology, neurotoxicology, molecular neurobiology, behavioural sciences, biocybernetics and clinical neurobiology.The over-riding criteria for publication are novelty and interest to a multidisciplinary audience. Neuroscience Letters is not a repository for material which, although sound, is neither particularly novel nor meriting urgent publication. Papers not sufficiently substantiated by experimental detail will not be published. Authors will be required where appropriate to show that they have paid attention to the guidelines in the Editorial: ethical principles for the maintenance and use of animals in neuroscience research, published in Neuroscience Letters, Vol.73, 1987, p.1. Any technical queries arising will be referred back to the author, although the Editors reserve the right to make alterations in the text without altering the technical content. Submission of a paper to Neuroscience Letters implies that it is not being submitted for publication elsewhere. Manuscripts submitted under multiple authorship are reviewed on the assumption that all listed authors concur with the submission and that a copy of the final manuscript has been approved by all authors and tacitly or explicitly by the responsible authorities in the laboratories where the work was carried out. If accepted, the manuscript shall not be published elsewhere in the same form, in either the same or another language, without the consent of the Editors and Publisher.
该杂志为神经解剖学、神经化学、神经内分泌学、神经药理学、神经生理学、神经毒理学、分子神经生物学、行为科学、生物细胞学和临床神经生物学领域的所有领域提供了简短而完整的报告,但没有提供初步的交流。出版的首要标准是多学科读者的新颖性和兴趣。神经科学信件并不是一个存储材料的仓库,尽管它听起来并不特别新颖,也不值得紧急出版。未经实验细节充分证实的论文将不予发表。在适当的情况下,作者将被要求表明他们已经注意了发表在《神经科学研究中维护和使用动物的伦理原则》社论中的指导方针,发表在《神经科学快报》1987年第73卷第1页。如有任何技术上的疑问,我们将向作者提出,但编辑保留在不改变技术内容的情况下修改文本的权利。向《神经科学快报》提交一篇论文意味着它不会在其他地方发表。以多重作者身份提交的稿件将在假定所有列出的作者都同意提交的情况下进行审查,并且最终稿件的副本已得到所有作者的批准,并已由进行工作的实验室的主管当局默认或明确地批准。未经编辑出版者同意,稿件不得在其他地方以相同的形式、相同的文字或者其他文字发表。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
NEUROSCIENCES (神经科学) 4区 |
188/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
706 | 680 | 26 |
引文计数(2018)
文献(2015-2017)
4992次引用
2215篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Neuroscience
小类(学科):General Neuroscience
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#55/111
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审稿时间: 2个月内 接受率: 中等(50%命中)
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研究方向:SNP
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研究方向:神经科学 神经环路
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研究方向:阿尔茨海默病 小胶质细胞
接受率: 一般容易(75%命中)
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研究方向:神经生物 麻醉
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研究方向:神经病毒
影响因子:2.995
ISSN:0028-3940
研究方向:医学-核医学
影响因子:2.324
ISSN:1051-2284
研究方向:医学-核医学
影响因子:3.156
ISSN:1869-1439
研究方向:CLINICAL NEUROLOGY-RADIOLOGY, NUCLEAR MEDICINE & M
影响因子:4.6
ISSN:0150-9861
研究方向:医学-核医学
影响因子:1.764
ISSN:1591-0199
研究方向:CLINICAL NEUROLOGY-RADIOLOGY, NUCLEAR MEDICINE & M
影响因子:4.966
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研究方向:医学-核医学
影响因子:3.005
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研究方向:医学-核医学
影响因子:2.396
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研究方向:OPTICS-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGI
影响因子:3.632
ISSN:1084-9785
研究方向:医学-核医学
发表一篇学和医学成像类SCI论文
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