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Abstract:
OBJECTIVE:Dopamine agonists are the main pharmacological intervention for the motor symptoms of Parkinson's disease (PD). However, dopaminergic medication has been associated with disinhibitory psychopathology in some patients. The aim of this study was to test the effect of dopaminergic medication on inhibitory control in patients with PD using the paced Random Number Generation task (RNG), which requires inhibition of prepotent counting in series to produce a random sequence of numbers. METHOD:Twenty-three PD patients performed RNG on and off dopaminergic medication. Cognitive load was manipulated by performing RNG at faster (1Hz) and slower (0.5 Hz) rates. For RNG, two scores (CS1 and CS2) were derived, which are considered indices of more automatic and more controlled counting, respectively. RESULTS:There were no main effects of medication on RNG performance. There was a significant main effect of cognitive load on CS1, with higher CS1 scores at the faster rate (p = <.01). A significant interaction effect between medication and rate (cognitive load; p = .03) followed by post hoc testing, revealed that CS2 scores were higher, on medication, at the slower but not the faster rate. CONCLUSIONS:Patients with PD displayed increased use of more controlled processing strategies on medication at the slowest rate of RNG. Therefore, while dopaminergic medication has been associated with disinhibitory psychopathology, our results suggest that dopamine therapy may enhance some forms of inhibitory cognitive control in PD, but only if there is sufficient time to engage controlled processing strategies. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
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最新影响因子:3.424 | 期刊ISSN:0894-4105 | CiteScore:3.12 |
出版周期:Quarterly | 是否OA:YES | 出版年份:1987 |
自引率:2.50% | 研究方向:医学-神经科学 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Neuropsychology focuses on (a) basic research, (b) the integration of basic and applied research, and (c) improved practice in the field of neuropsychology. The primary function of Neuropsychology is to publish original, empirical research on the relation between brain and human cognitive, emotional, and behavioral function. Sought are submissions of human experimental, cognitive, and behavioral research with implications for neuropsychological theory and practice. Articles that increase understanding of neuropsychological functions in both normal and disordered states and across the lifespan are encouraged. Applied, clinical research that will stimulate systematic experimental, cognitive, and behavioral investigations as well as improve the effectiveness, range, and depth of application is germane. Neuropsychology seeks to be the vehicle for the best research and ideas in the field.
《神经心理学》侧重于(a)基础研究,(b)基础研究和应用研究的整合,以及(c)神经心理学领域的改进实践。神经心理学的主要功能是发表关于大脑与人类认知、情感和行为功能之间关系的原始、实证研究。寻求的是人类实验、认知和行为研究的提交,对神经心理学理论和实践有影响。鼓励在正常和无序状态以及整个寿命期内增加对神经心理学功能理解的文章。应用,临床研究,这将刺激系统的实验,认知和行为调查,以及提高效益,范围和应用的深度有密切关系。神经心理学寻求成为该领域最佳研究和想法的载体。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
NEUROSCIENCES (神经科学) 4区 PSYCHOLOGY (心理学) 3区 PSYCHOLOGY, CLINICAL (心理学:临床) |
152/261 27/78 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
86 | 84 | 2 |
引文计数(2018)
文献(2015-2017)
932次引用
299篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Psychology
小类(学科):Neuropsychology and Physiological Psychology
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影响因子:5.315
ISSN:0148-396X
研究方向:医学-临床神经学
影响因子:1.725
ISSN:0028-3770
研究方向:医学-临床神经学
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影响因子:4.332
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研究方向:CLINICAL NEUROLOGY-SURGERY
影响因子:2.816
ISSN:0001-6268
研究方向:医学-临床神经学
影响因子:2.8
ISSN:0344-5607
研究方向:医学-临床神经学
影响因子:0.972
ISSN:1019-5149
研究方向:医学-临床神经学
影响因子:1.532
ISSN:0256-7040
研究方向:医学-临床神经学
影响因子:1.165
ISSN:1016-2291
研究方向:医学-临床神经学
发表一篇学和医学成像类SCI论文
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