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Abstract:
:The balance of excitation and inhibition is essential for cortical information processing, relying on the tight orchestration of the underlying subcellular processes. Dynamic transcriptional control by DNA methylation, catalyzed by DNA methyltransferases (DNMTs), and DNA demethylation, achieved by ten-eleven translocation (TET)-dependent mechanisms, is proposed to regulate synaptic function in the adult brain with implications for learning and memory. However, focus so far is laid on excitatory neurons. Given the crucial role of inhibitory cortical interneurons in cortical information processing and in disease, deciphering the cellular and molecular mechanisms of GABAergic transmission is fundamental. The emerging relevance of DNMT and TET-mediated functions for synaptic regulation irrevocably raises the question for the targeted subcellular processes and mechanisms. In this study, we analyzed the role dynamic DNA methylation has in regulating cortical interneuron function. We found that DNMT1 and TET1/TET3 contrarily modulate clathrin-mediated endocytosis. Moreover, we provide evidence that DNMT1 influences synaptic vesicle replenishment and GABAergic transmission, presumably through the DNA methylation-dependent transcriptional control over endocytosis-related genes. The relevance of our findings is supported by human brain sample analysis, pointing to a potential implication of DNA methylation-dependent endocytosis regulation in the pathophysiology of temporal lobe epilepsy, a disease characterized by disturbed synaptic transmission.
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最新影响因子:4.861 | 期刊ISSN:1047-3211 | CiteScore:5.87 |
出版周期:Monthly | 是否OA:YES | 出版年份:1991 |
期刊官方网址:http://cercor.oxfordjournals.org/
期刊投稿地址:http://www.oxfordjournals.org/our_journals/cercor/for_authors/submission_online.html
自引率:5.20% | 研究方向:医学-神经科学 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Cerebral Cortex publishes papers on the development organization plasticity and function of the cerebral cortex including the hippocampus. Studies with clear relevance to the cerebral cortex such as the thalamocortical relationship or cortico-subcortical interactions are also included. The journal is multidisciplinary and covers the large variety of modern neurobiological and neuropsychological techniques including anatomy biochemistry molecular neurobiology electrophysiology behavior artificial intelligence and theoretical modeling. In addition to research articles special features such as brief reviews book reviews and commentaries are included. Cerebral Cortex is published 8 times yearly.
《大脑皮层》发表关于大脑皮层包括海马的发育、组织、可塑性和功能的论文。与大脑皮层有明显相关性的研究,如丘脑皮质关系或皮质-皮质下相互作用也包括在内。该杂志是多学科的,涵盖了多种现代神经生物学和神经心理学技术,包括解剖学、生物化学、分子神经生物学、电生理学、行为、人工智能和理论建模。除了研究文章,特别功能,如简要评论,书评和评论包括。《大脑皮层》每年出版8期。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
NEUROSCIENCES (神经科学) 2区 |
24/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
441 | 441 | 0 |
引文计数(2018)
文献(2015-2017)
6274次引用
1068篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Neuroscience
小类(学科):Cognitive Neuroscience
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#6/90
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2 |
大类(学科):Neuroscience
小类(学科):Cellular and Molecular Neuroscience
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#8/85
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研究方向:医药科学 神经系统 精神疾病 神经症 应激相关障碍
审稿时间: 1个月内
liting7111
研究方向:生命科学 神经科学 认知科学 心理学
审稿时间: 3个月内
liting7111
研究方向:生命科学 神经科学 认知科学 心理学 神经生物学
审稿时间: 1个月内
liting7111
研究方向:神经科学
审稿时间: 2个月内 接受率: 比较困难(25%命中)
影响因子:5.576
ISSN:0885-3924
研究方向:医学-临床神经学
影响因子:6.005
ISSN:0192-415X
研究方向:医学-全科医学与补充医学
影响因子:202.731
ISSN:0140-6736
研究方向:医学-医学:内科
影响因子:2.898
ISSN:1807-5932
研究方向:医学-医学:内科
影响因子:1.817
ISSN:0025-7974
研究方向:医学-医学:内科
影响因子:3.006
ISSN:2044-6055
研究方向:MEDICINE, GENERAL & INTERNAL-
影响因子:0.834
ISSN:0020-9554
研究方向:医学-医学:内科
影响因子:0.522
ISSN:1108-4189
研究方向:MEDICINE, GENERAL & INTERNAL-
影响因子:11.15
ISSN:1741-7015
研究方向:医学-医学:内科
CEREBRAL CORTEX 投稿经验
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