发表一篇学和医学成像类SCI论文
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Abstract:
:Schizophrenia is associated with cognitive and behavioral dysfunctions thought to reflect imbalances in neurotransmission systems. Recent screenings suggested that lack of (functional) syndapin I (PACSIN1) may be linked to schizophrenia. We therefore studied syndapin I KO mice to address the suggested causal relationship to schizophrenia and to analyze associated molecular, cellular, and neurophysiological defects. Syndapin I knockout (KO) mice developed schizophrenia-related behaviors, such as hyperactivity, reduced anxiety, reduced response to social novelty, and an exaggerated novel object response and exhibited defects in dendritic arborization in the cortex. Neuromorphogenic deficits were also observed for a schizophrenia-associated syndapin I mutant in cultured neurons and coincided with a lack of syndapin I-mediated membrane recruitment of cytoskeletal effectors. Syndapin I KO furthermore caused glutamatergic hypofunctions. Syndapin I regulated both AMPAR and NMDAR availabilities at synapses during basal synaptic activity and during synaptic plasticity-particularly striking were a complete lack of long-term potentiation and defects in long-term depression in syndapin I KO mice. These synaptic plasticity defects coincided with alterations of postsynaptic actin dynamics, synaptic GluA1 clustering, and GluA1 mobility. Both GluA1 and GluA2 were not appropriately internalized. Summarized, syndapin I KO led to schizophrenia-like behavior, and our analyses uncovered associated molecular and cellular mechanisms.
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最新影响因子:4.861 | 期刊ISSN:1047-3211 | CiteScore:5.87 |
出版周期:Monthly | 是否OA:YES | 出版年份:1991 |
期刊官方网址:http://cercor.oxfordjournals.org/
期刊投稿地址:http://www.oxfordjournals.org/our_journals/cercor/for_authors/submission_online.html
自引率:5.20% | 研究方向:医学-神经科学 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Cerebral Cortex publishes papers on the development organization plasticity and function of the cerebral cortex including the hippocampus. Studies with clear relevance to the cerebral cortex such as the thalamocortical relationship or cortico-subcortical interactions are also included. The journal is multidisciplinary and covers the large variety of modern neurobiological and neuropsychological techniques including anatomy biochemistry molecular neurobiology electrophysiology behavior artificial intelligence and theoretical modeling. In addition to research articles special features such as brief reviews book reviews and commentaries are included. Cerebral Cortex is published 8 times yearly.
《大脑皮层》发表关于大脑皮层包括海马的发育、组织、可塑性和功能的论文。与大脑皮层有明显相关性的研究,如丘脑皮质关系或皮质-皮质下相互作用也包括在内。该杂志是多学科的,涵盖了多种现代神经生物学和神经心理学技术,包括解剖学、生物化学、分子神经生物学、电生理学、行为、人工智能和理论建模。除了研究文章,特别功能,如简要评论,书评和评论包括。《大脑皮层》每年出版8期。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
NEUROSCIENCES (神经科学) 2区 |
24/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
441 | 441 | 0 |
引文计数(2018)
文献(2015-2017)
6274次引用
1068篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Neuroscience
小类(学科):Cognitive Neuroscience
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#6/90
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2 |
大类(学科):Neuroscience
小类(学科):Cellular and Molecular Neuroscience
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#8/85
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研究方向:医药科学 神经系统 精神疾病 神经症 应激相关障碍
审稿时间: 1个月内
liting7111
研究方向:生命科学 神经科学 认知科学 心理学
审稿时间: 3个月内
liting7111
研究方向:生命科学 神经科学 认知科学 心理学 神经生物学
审稿时间: 1个月内
liting7111
研究方向:神经科学
审稿时间: 2个月内 接受率: 比较困难(25%命中)
影响因子:1.714
ISSN:1386-2073
研究方向:化学-生化研究方法
影响因子:6.088
ISSN:1933-7213
研究方向:医学-神经科学
影响因子:1.379
ISSN:0362-5664
研究方向:医学-临床神经学
影响因子:4.287
ISSN:1473-7175
研究方向:CLINICAL NEUROLOGY-PHARMACOLOGY & PHARMACY
影响因子:1.821
ISSN:1528-4336
研究方向:医学-传染病学
影响因子:2.385
ISSN:1120-009X
研究方向:医学-药学
影响因子:2.706
ISSN:1076-6294
研究方向:医学-传染病学
影响因子:4.177
ISSN:1178-6973
研究方向:-
影响因子:5.758
ISSN:0305-7453
研究方向:医学-传染病学
发表一篇学和医学成像类SCI论文
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