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Abstract:
PURPOSE:To evaluate the anterior chamber angle status and estimate the intraocular pressure (IOP) in patients with mucopolysaccharidoses (MPSs) type I, II, IV, and VI. DESIGN:Prospective cross-sectional study. METHODS:This study enrolled 27 consecutive MPS patients (8 patients with MPS I, 4 patients with MPS II, 9 patients with MPS IV, and 6 patients with MPS VI) and 20 normal control subjects. Anterior chamber angle status was evaluated by swept-source optical coherence tomography and IOP was estimated by the new-generation tonometer Corvis ST. RESULTS:Twelve eyes (6 patients) of 15 eyes (8 patients) with MPS I had narrow angles or peripheral iridocorneal touches together with elevated IOP (80%). Six eyes (3 patients) of 8 eyes (4 patients) with MPS II had plateau iris configuration, but all 8 eyes had normal IOP. All 18 eyes (9 patients) with MPS IV had normal angle structures, but 8 eyes (4 patients) had elevated IOP (44.4%). Nine eyes (5 patients) of 11 eyes (6 patients) with MPS VI had shallow but not closed angles (81.8%). Among these 9 eyes, 5 eyes had elevated IOP, and 4 of these 5 eyes had IOP >30 mm Hg. The trabecular iris angles of MPS types I, II, and VI were smaller than those of MPS type IV and of the control subjects. The angle recess areas of MPS types I and VI were smaller than those of MPS type IV and of the control subjects. CONCLUSIONS:MPS type I patients are prone to have glaucoma with narrow or closed angles; MPS type II patients tend to have plateau iris; MPS type IV patients are vulnerable to open-angle glaucoma; MPS type VI patients have narrow angles not as close as those of MPS type I. MPS types I, IV, and VI had higher IOP estimates than the control subjects, but only MPS I and IV had higher corrected IOP estimates than the control subjects. The ordinary IOP estimates in MPS VI patients may be falsely high because of clouded corneas and increased corneal rigidity. Swept-source optical coherence tomography helps ophthalmologist investigate the angle structure and the pathophysiology of glaucoma caused by MPS.
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最新影响因子:5.488 | 期刊ISSN:0002-9394 | CiteScore:3.64 |
出版周期:Monthly | 是否OA:YES | 出版年份:1884 |
期刊官方网址:http://www.ajo.com/
自引率:6.80% | 研究方向:医学-眼科学 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The American Journal of Ophthalmology is a peer-reviewed, scientific publication directed to ophthalmologists and visual science specialists describing clinical investigations, clinical observations, and clinically relevant laboratory investigations related to ophthalmology.
《美国眼科杂志》是一份经过同行评审的科学刊物,面向眼科医生和视觉科学专家,描述与眼科相关的临床调查、临床观察和临床相关实验室调查。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
OPHTHALMOLOGY (眼科学) 2区 |
6/59 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
263 | 259 | 4 |
引文计数(2018)
文献(2015-2017)
4576次引用
1257篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Ophthalmology
|
#4/108
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研究方向:医学 眼科学
审稿时间: 4个月内
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研究方向:青光眼
审稿时间: 2个月内 接受率: 比较困难(25%命中)
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研究方向:眼眶病
接受率: 比较困难(25%命中)
影响因子:2.473
ISSN:1362-4393
研究方向:医学-临床神经学
影响因子:1.14
ISSN:1443-9646
研究方向:CLINICAL NEUROLOGY-NEUROSCIENCES
影响因子:1.986
ISSN:1053-8135
研究方向:CLINICAL NEUROLOGY-REHABILITATION
影响因子:1.907
ISSN:1751-8423
研究方向:CLINICAL NEUROLOGY-PEDIATRICS
影响因子:3.117
ISSN:0885-9701
研究方向:医学-康复医学
影响因子:4.895
ISSN:1545-9683
研究方向:医学-康复医学
影响因子:4.655
ISSN:1557-0576
研究方向:CLINICAL NEUROLOGY-REHABILITATION
影响因子:1.452
ISSN:0898-5669
研究方向:PEDIATRICS-REHABILITATION
影响因子:2.297
ISSN:0194-2638
研究方向:PEDIATRICS-REHABILITATION
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