Effects of secukinumab on metabolic and liver parameters in plaque psoriasis patients.

Abstract:
BACKGROUND:Psoriasis is associated with metabolic, liver and cardiovascular comorbidity. Secukinumab, a fully human monoclonal antibody that selectively neutralizes interleukin-17A, has shown significant and sustained efficacy in the treatment of moderate to severe psoriasis. OBJECTIVES:This was an exploratory post hoc analysis of pooled data from three phase 3 studies in plaque psoriasis patient populations. The objective was to show the course of metabolic and liver parameters under secukinumab, etanercept or placebo treatment over time. A further objective was to assess the impact of selected comorbidities and metabolic characteristics on high-sensitivity C-reactive protein (hs-CRP), as a surrogate marker of systemic inflammation. METHODS:Data from the phase 3 randomized controlled trials [FIXTURE (NCT01358578), ERASURE (NCT01365455) and SCULPTURE (NCT01406938); n = 3010] were included in this analysis. Patients were treated with secukinumab 150 mg or 300 mg, placebo or etanercept 50 mg (FIXTURE only) as active comparator. A set of metabolic and liver parameters was longitudinally assessed over 52 weeks. Multivariate regression analyses assessed the impact of selected comorbidities and metabolic characteristics on hs-CRP levels at baseline and under treatment. RESULTS:Secukinumab treatment reduced hs-CRP levels. Body weight and uric acid levels tended to decrease over 52 weeks with secukinumab. Secukinumab showed a neutral effect on fasting plasma glucose, lipid parameters and liver enzymes. Psoriatic arthritis, metabolic syndrome, obesity, impaired glucose metabolism, and hyperuricemia were each associated with increased hs-CRP levels at baseline. Concomitant obesity attenuated the decline in hs-CRP under treatment. CONCLUSIONS:These analyses suggest neutral to favourable long-term trends in metabolic and liver parameters under secukinumab treatment. Metabolic comorbidities were associated with increased hs-CRP levels, reflecting the role of systemic inflammatory processes in their pathophysiology.
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JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
J EUR ACAD DERMATOL
最新影响因子:9.228 | 期刊ISSN:0926-9959 | CiteScore:2.55 |
出版周期:Bimonthly | 是否OA:YES | 出版年份:1992 |
期刊官方网址:http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1468-3083
自引率:9.90% | 研究方向:医学-皮肤病学 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY 期刊简介
英文简介:
The Journal of the European Academy of Dermatology and Venereology publishes articles of general and practical interest in the field of Dermatology and Venereology on clinical and basic science topics, as well as research with practical implications. The Journal also publishes: editorials, review and practice articles, original papers of general interest, short reports, case reports, letters to the editor, news items, features and Academy announcements.
中文简介:(来自Google、百度翻译)
欧洲皮肤病学和性病学会的杂志出版在皮肤病学和性病学领域的一般和实际兴趣的文章在临床和基础科学的主题,以及具有实际意义的研究。该杂志还出版:社论、评论和实践文章、一般感兴趣的原始论文、短篇报告、案例报告、给编辑的信、新闻项目、专题和学院公告。
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY 期刊中科院评价数据
最新中科院分区
大类(学科) | 小类(学科) | 学科排名 |
医学 |
DERMATOLOGY(皮肤病学) 2区 |
7/64 |
最新公布的期刊年发文量
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
277 | 221 | 56 |
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JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY 期刊CiteScore评价数据
最新CiteScore值
引文计数(2018)
文献(2015-2017)
3788次引用
1484篇文献
CiteScore排名
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Dermatology
|
#16/130
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|
|
2 |
大类(学科):Medicine
小类(学科):Infectious Diseases
|
#83/266
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|
|
CiteScore趋势图
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