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Abstract:
BACKGROUND:Vismodegib demonstrated 60% response rates in the ERIVANCE trial. Basal cell carcinoma has various histopathologies. Their effect on response is unclear. OBJECTIVE:The purpose of this study was to determine whether basal cell carcinoma histopathology affected vismodegib response. METHODS:This phase 2b, single-center, prospective case series study compared the efficacy of vismodegib in infiltrative, nodular, and superficial basal cell carcinomas treated for 12 or 24 weeks in 27 patients. Patients had 1 target lesion and up to 3 nontarget lesions. RESULTS:Twenty-seven patients were enrolled, with 65 tumors (27 target lesions/38 nontarget lesions). At 24 weeks, most basal cell carcinomas achieved histologic clearance, with positive biopsy results in 10.5% of target lesions, 30.4% of nontarget lesions, and 21.4% overall. No statistical differences were observed between histopathologic subtypes. One hundred percent of patients experienced an adverse event, 94% grade 1 or 2. The most common adverse events were dysgeusia/loss of taste (86%), muscle spasms (82%), and alopecia (71%). Clinically progressive disease during treatment was low (1.5%). Two patients had recurrence within 1 year of treatment. LIMITATIONS:Limitations included sample size of basal cell carcinoma histopathologic subtypes, sampling punch biopsies, and short follow-up. CONCLUSIONS:Basal cell histopathologic subtype did not significantly affect response to vismodegib. Each subtype was observed to completely respond at 12 weeks of therapy, 24 weeks, or both.
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最新影响因子:15.487 | 期刊ISSN:0190-9622 | CiteScore:2.93 |
出版周期:Monthly | 是否OA:YES | 出版年份:1979 |
期刊官方网址:http://www.journals.elsevier.com/journal-of-the-american-academy-of-dermatology/
自引率:8.40% | 研究方向:医学-皮肤病学 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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As the official publication of the American Academy of Dermatology, the Journal is dedicated to the clinical and continuing education needs of the entire dermatologic community and is internationally known as the leading journal in the field. Original, peer-reviewed articles cover clinical and investigative studies, treatments, new diagnostic techniques, and other topics relating to the prevention, diagnosis, and treatment of disorders of the skin. Included are CME articles based on the Core Curriculum of the American Academy of Dermatology. The Journal ranks in the top 5.4% of the 4,779 scientific journals most frequently cited (Science Citation Index). Journal of the American Academy of Dermatology is also recommended for purchase in the Brandon-Hill study, Selected List of Books and Journals for the Small Medical Library (1997/98 Edition).
作为美国皮肤学会的官方出版物,该杂志致力于整个皮肤病学社区的临床和继续教育的需要,是国际知名的领先杂志在该领域。原创的,同行评审的文章涵盖临床和调查研究,治疗,新的诊断技术,和其他主题有关的预防,诊断和治疗的皮肤疾病。包括基于美国皮肤病学会核心课程的CME文章。在4779种最常被引用的科学期刊(科学引文索引)中,该期刊排名前5.4%。《美国皮肤学会杂志》也被推荐在Brandon-Hill研究中购买,该研究为小型医学图书馆(1997/98版)挑选了一些书籍和期刊。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
DERMATOLOGY(皮肤病学) 1区 |
2/64 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
288 | 245 | 43 |
引文计数(2018)
文献(2015-2017)
5869次引用
2000篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Dermatology
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#10/130
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研究方向:临床皮肤 皮肤流行病 皮肤基础
接受率: 一般容易(75%命中)
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研究方向:临床研究 皮肤病理 综述
接受率: 非常困难(几乎不命中)
影响因子:2.995
ISSN:0028-3940
研究方向:医学-核医学
影响因子:2.324
ISSN:1051-2284
研究方向:医学-核医学
影响因子:3.156
ISSN:1869-1439
研究方向:CLINICAL NEUROLOGY-RADIOLOGY, NUCLEAR MEDICINE & M
影响因子:4.6
ISSN:0150-9861
研究方向:医学-核医学
影响因子:1.764
ISSN:1591-0199
研究方向:CLINICAL NEUROLOGY-RADIOLOGY, NUCLEAR MEDICINE & M
影响因子:4.966
ISSN:0195-6108
研究方向:医学-核医学
影响因子:3.005
ISSN:0301-0449
研究方向:医学-核医学
影响因子:2.396
ISSN:1793-5458
研究方向:OPTICS-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGI
影响因子:3.632
ISSN:1084-9785
研究方向:医学-核医学
发表一篇学和医学成像类SCI论文
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