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CRH receptor antagonists from Pulsatilla chinensis prevent CRH-induced premature catagen transition in human hair follicles.



BACKGROUND:There is a growing interest in the relationship among stress hormones, neuroendocrine signaling, and skin diseases, including hair loss. Previous reports showed that stress hormones inhibit human hair growth and induce early catagen transition. Moreover, a CRH receptor antagonist reversed CRH-induced alopecia in a mouse model, suggesting that antagonization of the CRH receptor is a key clinical strategy to treat stress-induced hair loss. OBJECTIVES:The aim of this study was to investigate the protective effect of CRH receptor antagonists from Pulsatilla chinensis on human hair follicles (hHFs) and human dermal papilla cells (hDPCs). METHODS:hHFs were observed and scored by hair cycle. The levels of cAMP, a second messenger, were measured in each group. In addition, the mRNA and protein levels of factors related to the hair cycle were measured. Furthermore, the expression levels of various members of the mitogen-activated protein kinase (MAPK) signaling pathway related to stress were measured. RESULTS:CRH induced early catagen transition in an ex vivo hair organ culture model. In addition, CRH downregulated the levels of alkaline phosphatase (ALP) and hair anagen-related cytokines in cultured hDPCs. Moreover, CRH induced the phosphorylation of JNK, c-Jun, p38, ERK, and Akt in cultured hDPCs. CRH receptor antagonists isolated from P chinensis reversed these CRH-induced modulations in both ex vivo hair follicles (HFs) and cultured hDPCs. CONCLUSIONS:These results indicate that P chinensis effectively blocks CRH receptor function and that saponin derivatives from P chinensis could be a pharmaceutical and cosmetic approach to treat stress-induced hair loss.


Journal of Cosmetic Dermatology

最新影响因子:2.189 期刊ISSN:1473-2130 CiteScore:1.75
出版周期: 是否OA:YES 出版年份:2002



自引率:4.40% 研究方向:DERMATOLOGY-

SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)

NCBI查询:PubMed Central (PMC)链接全文检索(pubmed central)


Journal of Cosmetic Dermatology 期刊简介


Overview The Journal of Cosmetic Dermatology is the official journal of the International Academy of Cosmetic Dermatology (IACD) and the Canadian Association of Aesthetic Medicine (CAAM). The Journal publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques. Journal of Cosmetic Dermatology strengthens the bridge between the best of cosmetic science available in industry and dermatology to bring readers the most cutting edge information, organized in the following innovative sections: Editorial Echoes - timely evaluation of the latest policies and trends Cosmetic Commentary - explaining a controversial or confusing issue Review Article - presenting the latest information on the subject Original Contributions - peer reviewed submissions Master Case Presentations – expert analysis and protocol recommendations based on a case photograph Letters to the Editor - controversial articles published with an editorial reply Meeting Moments - highlights from major global dermatology meetings Journal Innoventions - cutting edge techniques and industry developments Book Reviews - updates on the latest literature Diary of Cosmetic Dermatology – upcoming meetings in the field Parting Thoughts - summaries of the issue’s key ideas Aims and Scope The Journal of Cosmetic Dermatology publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques. The scope of coverage includes, but will not be limited to: healthy skin; skin maintenance; ageing skin; photodamage and photoprotection; rejuvenation; biochemistry, endocrinology and neuroimmunology of healthy skin; imaging; skin measurement; quality of life; skin types; sensitive skin; rosacea and acne; sebum; sweat; fat; phlebology; hair conservation, restoration and removal; nails and nail surgery; pigment; psychological and medicolegal issues; retinoids; cosmetic chemistry; dermopharmacy; cosmeceuticals; toiletries; striae; cellulite; cosmetic dermatological surgery; blepharoplasty; liposuction; surgical complications; botulinum; fillers, peels and dermabrasion; local and tumescent anaesthesia; electrosurgery; lasers, including laser physics, laser research and safety, vascular lasers, pigment lasers, hair removal lasers, tattoo removal lasers, resurfacing lasers, dermal remodelling lasers and laser complications. Keywords Journal of Cosmetic Dermatology, JCD, cosmetic surgery, laser surgery, cutanaeous surgery, aesthetic dermatology, aesthetic surgery Abstracting and Indexing Information Academic Search (EBSCO Publishing) Academic Search Alumni Edition (EBSCO Publishing) Academic Search Premier (EBSCO Publishing) Current Contents: Clinical Medicine (Clarivate Analytics) Embase (Elsevier) InfoTrac (GALE Cengage) MEDLINE/PubMed (NLM) Science Citation Index Expanded (Clarivate Analytics) VINITI (All-Russian Institute of Science & Technological Information) Web of Science (Clarivate Analytics)


概述 《美容皮肤医学杂志》是国际美容皮肤医学学会(IACD)和加拿大美容医学协会(CAAM)的官方期刊。 该杂志出版高质量的,同行评审的文章关于美容皮肤病学的所有方面,旨在促进最高标准的患者护理在美容皮肤病学。《美容皮肤病学杂志》每季出版一次,促进持续的专业发展,并为科学研究和创新技术的交流提供了一个论坛。 《美容皮肤病学杂志》加强了业界最好的美容科学与皮肤病学之间的桥梁,为读者带来最前沿的信息,组织在以下创新部分: 编辑回应-及时评估最新的政策和趋势 化妆品评论-解释一个有争议或令人困惑的问题 评论文章-提供关于这个主题的最新信息 最初的贡献-同行审查提交 案例演示-基于案例照片的专家分析和方案建议 给编辑的信-有争议的文章发表了编辑的答复 会议时刻-主要的全球皮肤病学会议的重点 期刊创新-尖端技术和工业发展 书评-最新文献的更新 美容皮肤病学日记-即将在该领域的会议 离别的想法-总结问题的关键思想 目标和范围 《美容皮肤病学杂志》发表高质量的同行评审文章,涉及美容皮肤病学的各个方面,旨在培养美容皮肤病学患者护理的最高标准。《美容皮肤病学杂志》每季出版一次,促进持续的专业发展,并为科学研究和创新技术的交流提供了一个论坛。 覆盖范围包括但不限于:健康皮肤;皮肤保养;老化皮肤;光损伤和光防护;恢复活力;健康皮肤的生物化学、内分泌和神经免疫学;成像;皮肤测量;生活质量;皮肤类型;敏感皮肤;酒渣鼻和痤疮;皮脂;汗液;脂肪;静脉学;毛发干扰物美容、修复和去除;指甲和指甲手术;色素;心理和法医问题;维甲酸类;化妆品化学;皮肤药理学;药妆;洗漱用品;纹状纹;脂肪组织;皮肤美容手术;眼睑成形术;吸脂术;手术并发症;肉毒杆菌;填充物、削皮和磨皮术;局部和肿胀感知;电外科;激光,包括激光物理、激光研究与安全、血管激光、色素激光、脱毛激光、纹身激光、表面激光、皮肤重塑激光和激光并发症。 关键字 美容皮肤科杂志,JCD,美容外科,激光外科,皮脂腺外科,美容皮肤科,美容外科 摘要和索引信息 学术检索(EBSCO出版) 学术搜索校友版(EBSCO出版) 学术搜寻总理(EBSCO出版) 目前内容:临床医学(科莱恩分析) Embase(爱思唯尔) InfoTrac(盖尔Cengage) MEDLINE / PubMed (NLM) 科学引文索引扩展(Clarivate Analytics) VINITI(全俄罗斯科学技术信息研究所) 科学网络(Clarivate Analytics)

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Journal of Cosmetic Dermatology 期刊中科院评价数据


大类(学科) 小类(学科) 学科排名
医学 DERMATOLOGY (皮肤病学) 4区


年度总发文量 年度论文发表量 年度综述发表量
90 78 12



Journal of Cosmetic Dermatology 期刊CiteScore评价数据










序号 类别 排名 百分位
大类(学科):Medicine 小类(学科):Dermatology
#42/130 点击查看排名表




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#42 130
Journal of Cosmetic Dermatology 1.75 第68百分位
来源出版物名称 CiteScore2017 百分位
Medical Photonics 4.40 第99百分位
Clinical Plasma Medicine 4.03 第98百分位
Fibrogenesis and Tissue Repair 3.86 第98百分位
Journal of Investigative Dermatology 3.69 第97百分位
Pigment Cell and Melanoma Research 3.38 第96百分位
American Journal of Clinical Dermatology 3.31 第95百分位
Wound Repair and Regeneration 3.09 第95百分位
Dermato-Endocrinology 3.06 第94百分位
Clinical, Cosmetic and Investigational Dermatology 2.97 第93百分位
Journal of the American Academy of Dermatology 2.93 第92百分位
Melanoma Research 2.91 第91百分位
Dermatologic Clinics 2.87 第91百分位
Photodiagnosis and Photodynamic Therapy 2.72 第90百分位
Mycoses 2.71 第89百分位
LGBT Health 2.63 第88百分位
British Journal of Dermatology 2.55 第87百分位
Journal of the European Academy of Dermatology and Venereology 2.55 第87百分位
Lasers in Surgery and Medicine 2.55 第87百分位
HIV/AIDS - Research and Palliative Care 2.52 第85百分位
Journal of Dermatological Science 2.49 第84百分位
Skin Pharmacology and Physiology 2.49 第84百分位
Dermatology and Therapy 2.47 第83百分位
Archives of Dermatological Research 2.44 第82百分位
Experimental Dermatology 2.34 第81百分位
Asia Pacific Allergy 2.31 第80百分位
Clinics in Dermatology 2.31 第80百分位
JAMA Dermatology 2.28 第79百分位
Contact Dermatitis 2.24 第78百分位
Dermatology 2.16 第78百分位
Lasers in Medical Science 2.14 第77百分位
Infectious Diseases in Obstetrics and Gynecology 2.04 第76百分位
BMC Dermatology 2.02 第75百分位
Dermatology Research and Practice 1.92 第74百分位
Journal of Skin Cancer 1.92 第74百分位
Sexual Medicine Reviews 1.89 第73百分位
Sexually Transmitted Infections 1.85 第72百分位
International Wound Journal 1.82 第71百分位
Photodermatology Photoimmunology and Photomedicine 1.81 第71百分位
Dermatitis 1.76 第69百分位
International Journal of Cosmetic Science 1.76 第69百分位
Journal of Dermatological Treatment 1.76 第69百分位
Journal of Cosmetic Dermatology 1.75 第68百分位
Acta Dermato-Venereologica 1.70 第67百分位
Journal of Lasers in Medical Sciences 1.69 第66百分位
Sexually Transmitted Diseases 1.69 第66百分位
Neurological Sciences 1.65 第64百分位
Sexual Medicine 1.65 第64百分位
AIDS Research and Treatment 1.63 第63百分位
Journal of Tissue Viability 1.63 第63百分位
Current Problems in Dermatology 1.56 第61百分位
Skin Research and Technology 1.55 第61百分位
Postepy Dermatologii I Alergologii 1.54 第60百分位
Dermatologic Surgery 1.48 第59百分位
Journal of Clinical and Aesthetic Dermatology 1.46 第58百分位
Journal of Dermatology 1.40 第58百分位
Journal of Cutaneous Pathology 1.36 第57百分位
Journal of Drugs in Dermatology 1.34 第56百分位
Dermatologic Therapy 1.24 第55百分位
International Journal of STD and AIDS 1.24 第55百分位
Australasian Journal of Dermatology 1.23 第54百分位
Journal of the International Association of Providers of AIDS Care 1.19 第53百分位
Anais Brasileiros de Dermatologia 1.18 第52百分位
Seminars in Cutaneous Medicine and Surgery 1.15 第51百分位
Journal of the American College of Clinical Wound Specialists 1.14 第51百分位
American Journal of Dermatopathology 1.12 第50百分位
International Journal of Dermatology 1.10 第49百分位
Journal of Cosmetic and Laser Therapy 1.10 第49百分位
Dermatology Reports 1.09 第47百分位
Journal of Dermatological Case Reports 1.09 第47百分位
Annals of Dermatology 1.06 第46百分位
Clinical and Experimental Dermatology 1.05 第45百分位
Pediatric Dermatology 1.05 第45百分位
International Journal of Sexual Health 1.03 第43百分位
JDDG - Journal of the German Society of Dermatology 1.03 第43百分位
Leprosy Review 1.03 第43百分位
Journal of Cutaneous Medicine and Surgery 0.96 第41百分位
Acta Dermatovenerologica Alpina, Panonica et Adriatica 0.91 第41百分位
European Journal of Dermatology 0.87 第40百分位
Case Reports in Dermatology 0.84 第39百分位
Advances in Skin and Wound Care 0.81 第38百分位
Indian Journal of Dermatology 0.81 第38百分位
Giornale Italiano di Dermatologia e Venereologia 0.77 第37百分位
Acta Dermatovenerologica Croatica 0.75 第36百分位
Actas Dermo-Sifiliograficas 0.73 第35百分位
Journal of Investigative Dermatology Symposium Proceedings 0.69 第35百分位
Psoriasis: Targets and Therapy 0.67 第34百分位
Dermatologica Sinica 0.65 第33百分位
International Journal of Trichology 0.65 第33百分位
Indian Journal of Dermatology, Venereology and Leprology 0.58 第31百分位
Dermatology Online Journal 0.55 第31百分位
Hautarzt 0.52 第30百分位
Journal of Cutaneous and Aesthetic Surgery 0.52 第30百分位
Indian Journal of Sexually Transmitted Diseases 0.48 第28百分位
Cutis 0.47 第28百分位
International Journal of Women's Dermatology 0.43 第27百分位
Southern African Journal of Epidemiology and Infection 0.38 第26百分位
Photonics and Lasers in Medicine 0.37 第25百分位
Biomedical Photonics 0.36 第25百分位
Annales de Dermatologie et de Venereologie 0.34 第24百分位
Serbian Journal of Dermatology and Venereology 0.29 第23百分位
Indian Journal of Leprosy 0.27 第22百分位
Wounds UK 0.25 第21百分位
Melanoma Management 0.20 第21百分位
Journal of Applied Cosmetology 0.19 第20百分位
Przeglad Dermatologiczny 0.15 第19百分位
Journal of Pakistan Association of Dermatologists 0.14 第18百分位
Surgical and Cosmetic Dermatology 0.14 第18百分位
Dermatologie in Beruf und Umwelt 0.12 第17百分位
Korean Journal of Dermatology 0.10 第16百分位
Turkderm Deri Hastaliklari ve Frengi Arsivi 0.10 第16百分位
Dermatologia Revista Mexicana 0.09 第15百分位
Open Dermatology Journal 0.08 第13百分位
Turk Dermatoloji Dergisi 0.08 第13百分位
Aktuelle Dermatologie 0.07 第12百分位
Iranian Journal of Dermatology 0.07 第12百分位
Hong Kong Journal of Dermatology and Venereology 0.06 第10百分位
Journal of the Egyptian Women's Dermatologic Society 0.06 第10百分位
Piel 0.06 第10百分位
Cesko-Slovenska Dermatologie 0.05 第8百分位
Forum for Nordic Dermato-Venerology 0.05 第8百分位
Medicina Cutanea Ibero-Latino-Americana 0.05 第8百分位
Acta Vulnologica 0.04 第6百分位
Japanese Journal of Leprosy 0.04 第6百分位
European Journal of Pediatric Dermatology 0.03 第4百分位
Nishinihon Journal of Dermatology 0.03 第4百分位
Revista Argentina de Dermatologia 0.02 第3百分位
Turkiye Klinikleri Dermatoloji 0.02 第3百分位
Journal of Clinical Dermatology 0.01 第1百分位
Clinical Skin Cancer 0.00 第0百分位
Haut 0.00 第0百分位






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