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Abstract:
BACKGROUND:There is a growing interest in the relationship among stress hormones, neuroendocrine signaling, and skin diseases, including hair loss. Previous reports showed that stress hormones inhibit human hair growth and induce early catagen transition. Moreover, a CRH receptor antagonist reversed CRH-induced alopecia in a mouse model, suggesting that antagonization of the CRH receptor is a key clinical strategy to treat stress-induced hair loss. OBJECTIVES:The aim of this study was to investigate the protective effect of CRH receptor antagonists from Pulsatilla chinensis on human hair follicles (hHFs) and human dermal papilla cells (hDPCs). METHODS:hHFs were observed and scored by hair cycle. The levels of cAMP, a second messenger, were measured in each group. In addition, the mRNA and protein levels of factors related to the hair cycle were measured. Furthermore, the expression levels of various members of the mitogen-activated protein kinase (MAPK) signaling pathway related to stress were measured. RESULTS:CRH induced early catagen transition in an ex vivo hair organ culture model. In addition, CRH downregulated the levels of alkaline phosphatase (ALP) and hair anagen-related cytokines in cultured hDPCs. Moreover, CRH induced the phosphorylation of JNK, c-Jun, p38, ERK, and Akt in cultured hDPCs. CRH receptor antagonists isolated from P chinensis reversed these CRH-induced modulations in both ex vivo hair follicles (HFs) and cultured hDPCs. CONCLUSIONS:These results indicate that P chinensis effectively blocks CRH receptor function and that saponin derivatives from P chinensis could be a pharmaceutical and cosmetic approach to treat stress-induced hair loss.
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最新影响因子:2.189 | 期刊ISSN:1473-2130 | CiteScore:1.75 |
出版周期: | 是否OA:YES | 出版年份:2002 |
期刊官方网址:http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1473-2165
自引率:4.40% | 研究方向:DERMATOLOGY- |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Overview The Journal of Cosmetic Dermatology is the official journal of the International Academy of Cosmetic Dermatology (IACD) and the Canadian Association of Aesthetic Medicine (CAAM). The Journal publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques. Journal of Cosmetic Dermatology strengthens the bridge between the best of cosmetic science available in industry and dermatology to bring readers the most cutting edge information, organized in the following innovative sections: Editorial Echoes - timely evaluation of the latest policies and trends Cosmetic Commentary - explaining a controversial or confusing issue Review Article - presenting the latest information on the subject Original Contributions - peer reviewed submissions Master Case Presentations – expert analysis and protocol recommendations based on a case photograph Letters to the Editor - controversial articles published with an editorial reply Meeting Moments - highlights from major global dermatology meetings Journal Innoventions - cutting edge techniques and industry developments Book Reviews - updates on the latest literature Diary of Cosmetic Dermatology – upcoming meetings in the field Parting Thoughts - summaries of the issue’s key ideas Aims and Scope The Journal of Cosmetic Dermatology publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques. The scope of coverage includes, but will not be limited to: healthy skin; skin maintenance; ageing skin; photodamage and photoprotection; rejuvenation; biochemistry, endocrinology and neuroimmunology of healthy skin; imaging; skin measurement; quality of life; skin types; sensitive skin; rosacea and acne; sebum; sweat; fat; phlebology; hair conservation, restoration and removal; nails and nail surgery; pigment; psychological and medicolegal issues; retinoids; cosmetic chemistry; dermopharmacy; cosmeceuticals; toiletries; striae; cellulite; cosmetic dermatological surgery; blepharoplasty; liposuction; surgical complications; botulinum; fillers, peels and dermabrasion; local and tumescent anaesthesia; electrosurgery; lasers, including laser physics, laser research and safety, vascular lasers, pigment lasers, hair removal lasers, tattoo removal lasers, resurfacing lasers, dermal remodelling lasers and laser complications. Keywords Journal of Cosmetic Dermatology, JCD, cosmetic surgery, laser surgery, cutanaeous surgery, aesthetic dermatology, aesthetic surgery Abstracting and Indexing Information Academic Search (EBSCO Publishing) Academic Search Alumni Edition (EBSCO Publishing) Academic Search Premier (EBSCO Publishing) Current Contents: Clinical Medicine (Clarivate Analytics) Embase (Elsevier) InfoTrac (GALE Cengage) MEDLINE/PubMed (NLM) Science Citation Index Expanded (Clarivate Analytics) VINITI (All-Russian Institute of Science & Technological Information) Web of Science (Clarivate Analytics)
概述 《美容皮肤医学杂志》是国际美容皮肤医学学会(IACD)和加拿大美容医学协会(CAAM)的官方期刊。 该杂志出版高质量的,同行评审的文章关于美容皮肤病学的所有方面,旨在促进最高标准的患者护理在美容皮肤病学。《美容皮肤病学杂志》每季出版一次,促进持续的专业发展,并为科学研究和创新技术的交流提供了一个论坛。 《美容皮肤病学杂志》加强了业界最好的美容科学与皮肤病学之间的桥梁,为读者带来最前沿的信息,组织在以下创新部分: 编辑回应-及时评估最新的政策和趋势 化妆品评论-解释一个有争议或令人困惑的问题 评论文章-提供关于这个主题的最新信息 最初的贡献-同行审查提交 案例演示-基于案例照片的专家分析和方案建议 给编辑的信-有争议的文章发表了编辑的答复 会议时刻-主要的全球皮肤病学会议的重点 期刊创新-尖端技术和工业发展 书评-最新文献的更新 美容皮肤病学日记-即将在该领域的会议 离别的想法-总结问题的关键思想 目标和范围 《美容皮肤病学杂志》发表高质量的同行评审文章,涉及美容皮肤病学的各个方面,旨在培养美容皮肤病学患者护理的最高标准。《美容皮肤病学杂志》每季出版一次,促进持续的专业发展,并为科学研究和创新技术的交流提供了一个论坛。 覆盖范围包括但不限于:健康皮肤;皮肤保养;老化皮肤;光损伤和光防护;恢复活力;健康皮肤的生物化学、内分泌和神经免疫学;成像;皮肤测量;生活质量;皮肤类型;敏感皮肤;酒渣鼻和痤疮;皮脂;汗液;脂肪;静脉学;毛发干扰物美容、修复和去除;指甲和指甲手术;色素;心理和法医问题;维甲酸类;化妆品化学;皮肤药理学;药妆;洗漱用品;纹状纹;脂肪组织;皮肤美容手术;眼睑成形术;吸脂术;手术并发症;肉毒杆菌;填充物、削皮和磨皮术;局部和肿胀感知;电外科;激光,包括激光物理、激光研究与安全、血管激光、色素激光、脱毛激光、纹身激光、表面激光、皮肤重塑激光和激光并发症。 关键字 美容皮肤科杂志,JCD,美容外科,激光外科,皮脂腺外科,美容皮肤科,美容外科 摘要和索引信息 学术检索(EBSCO出版) 学术搜索校友版(EBSCO出版) 学术搜寻总理(EBSCO出版) 目前内容:临床医学(科莱恩分析) Embase(爱思唯尔) InfoTrac(盖尔Cengage) MEDLINE / PubMed (NLM) 科学引文索引扩展(Clarivate Analytics) VINITI(全俄罗斯科学技术信息研究所) 科学网络(Clarivate Analytics)
大类(学科) | 小类(学科) | 学科排名 |
医学 |
DERMATOLOGY (皮肤病学) 4区 |
41/64 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
90 | 78 | 12 |
引文计数(2018)
文献(2015-2017)
319次引用
182篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Dermatology
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#42/130
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研究方向:医学-外周血管病
发表一篇学和医学成像类SCI论文
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