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Abstract:
:Early detection of Alzheimer's disease (AD) will help researchers to better understand the disease and develop improved treatments. Recent developments have thus focused on identifying biomarkers for mild cognitive impairment due to AD (MCI) and AD during the preclinical phase. The aim of this pilot study is to determine whether exhaled volatile organic compounds (VOCs) can be used as a non-invasive method to distinguish controls from MCI, controls from AD and to determine whether there are differences between MCI and AD. The study used gas chromatography-ion mobility spectrometry (GC-IMS) techniques. Confounding factors, such as age, smoking habits, gender and alcohol consumption are investigated to demonstrate the efficacy of results. One hundred subjects were recruited including 50 controls, 25 AD and 25 MCI patients. The subject cohort was age- and gender-matched to minimise bias. Breath samples were analysed using a commercial GC-IMS instrument (G.A.S. BreathSpec, Dortmund, Germany). Data analysis indicates that the GC-IMS signal was consistently able to separate between diagnostic groups [AUC ± 95%, sensitivity, specificity], controls versus MCI: [0.77 (0.64-0.90), 0.68, 0.80], controls versus AD: [0.83 (0.72-0.94), 0.60, 0.96], and MCI versus AD: [0.70 (0.55-0.85), 0.60, 0.84]. VOC analysis indicates that six compounds play a crucial role in distinguishing between diagnostic groups. Analysis of possible confounding factors indicate that gender, age, smoking habits and alcohol consumption have insignificant influence on breath content. This pilot study confirms the utility of exhaled breath analysis to distinguish between AD, MCI and control subjects. Thus, GC-IMS offers great potential as a non-invasive, high-throughput, diagnostic technique for diagnosing and potentially monitoring AD in a clinical setting.
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最新影响因子:2.929 | 期刊ISSN:1752-7155 | CiteScore:3.62 |
出版周期: | 是否OA:YES | 出版年份:2007 |
自引率:24.90% | 研究方向:BIOCHEMICAL RESEARCH METHODS-RESPIRATORY SYSTEM |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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This journal is dedicated to all aspects of breath science, with the major focus on analysis of exhaled breath in physiology and medicine, and the diagnosis and treatment of breath odours.
本杂志致力于呼吸科学的各个方面,主要侧重于分析呼出的呼吸在生理学和医学,以及诊断和治疗呼吸气味。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
BIOCHEMICAL RESEARCH METHODS(生化研究方法) 3区 RESPIRATORY SYSTEM(呼吸系统) 3区 |
24/79 20/60 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
66 | 62 | 4 |
引文计数(2018)
文献(2015-2017)
732次引用
202篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Pulmonary and Respiratory Medicine
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#17/132
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