发表一篇学和医学成像类SCI论文
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Abstract:
Subarachnoid hemorrhage is a common disease in the neural system, which causes high fatality rate. Therefore, it is necessary to figure out inner mechanisms of factors related to this disease. RT-qPCR was applied for measuring expressions of CDKN1B and miR-502-5p and other factors of apoptosis and inflammation. Cell viabilities were detected through CCK-8. Binding conditions between miR-502-5p and CDKN1B were detected through luciferase report assay. Western blot was used for measuring levels of proteins in PPARγ/NF-κB signaling pathway. Apoptosis and inflammation of HT22 cell line, a kind of nerve cell line, were enhanced and viabilities were suppressed by oxyhemoglobin. CDKN1B expressed lower in induced HT22 cell line and overexpressed CDKN1B could promote viabilities and suppress apoptosis as well as inflammation. MiR-502-5p was the target gene of CDKN1B and enhanced apoptosis and inflammation of cells in HT22 cell line. Furthermore, miR-502-5p reversed functions of CKDN1B in induced cells through regulating proteins in PPARγ/NF-κB signaling pathway. CDKN1B was the gene that could inhibit SAH caused by apoptosis in nerve cells and inflammation by sponging miR-502-5p and regulating factors in PPARγ/NF-κB signaling pathway, suggesting it could be a factor for protecting functions of nerve cells after SAH.
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最新影响因子:2.866 | 期刊ISSN:0895-8696 | CiteScore:2.37 |
出版周期:Monthly | 是否OA:YES | 出版年份:1989 |
自引率:4.20% | 研究方向:医学-神经科学 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The Journal of Molecular Neuroscience is committed to the rapid publication of original findings that increase our understanding of the molecular structure, function, and development of the nervous system.
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大类(学科) | 小类(学科) | 学科排名 |
医学 |
BIOCHEMISTRY & MOLECULAR BIOLOGY (生化与分子生物学) 4区 NEUROSCIENCES (神经科学) 4区 |
178/293 171/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
152 | 145 | 7 |
引文计数(2018)
文献(2015-2017)
1719次引用
724篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Neuroscience
小类(学科):Cellular and Molecular Neuroscience
|
#60/85
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审稿时间: 2个月内 接受率: 一般容易(75%命中)
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研究方向:医学 临床神经病学
审稿时间: 3个月内
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研究方向:医药科学 神经系统 精神疾病 神经变性、再生及相关疾病
审稿时间: 1个月内
影响因子:2.748
ISSN:0026-1394
研究方向:工程技术-物理:应用
影响因子:1.843
ISSN:0034-6748
研究方向:工程技术-物理:应用
影响因子:2.442
ISSN:0895-3996
研究方向:工程技术-光学
影响因子:1.643
ISSN:1768-6733
研究方向:INSTRUMENTS & INSTRUMENTATION-MATERIALS SCIENCE, C
影响因子:1.446
ISSN:0970-3950
研究方向:工程技术-物理:应用
影响因子:8.307
ISSN:2040-3364
研究方向:CHEMISTRY, MULTIDISCIPLINARY-NANOSCIENCE & NANOTEC
影响因子:6.739
ISSN:2191-9089
研究方向:CHEMISTRY, MULTIDISCIPLINARY-NANOSCIENCE & NANOTEC
影响因子:2.838
ISSN:2076-3417
研究方向:CHEMISTRY, MULTIDISCIPLINARYMATERIALS SCIE-MATERIA
影响因子:2.024
ISSN:1745-8080
研究方向:工程技术-材料科学:综合
发表一篇学和医学成像类SCI论文
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